Publications by authors named "Guanyan Cai"
Article Synopsis
- Congenital urinary tract anomalies are common in infants and often linked to issues in ureter development, but the exact mechanisms behind this connection are not well understood.
- The gene Robo2 is crucial for normal ureter formation and its loss can lead to defects like vesicoureteral reflux, but its specific role in development has remained unclear until now.
- Research shows that ROBO2 interacts with retinaldehyde dehydrogenase-2 (RALDH2) to influence the migration and fusion of structures involved in ureter development, with potential treatments like retinoic acid offering hope for correcting these anomalies.
