Assessment of human health risk induced by 7 metals exposure through drinking water in Urumqi, Xinjiang, China.

Heavy metal water pollution refers to the abnormal concentration of metal elements and their compounds in water with a relative density of >4.5, which causes the water quality to decline or deteriorate. To assess the presence of 7 metals in drinking water in a city in Xinjiang and the health risks to the human body caused by drinking the water and to provide a scientific basis for health risk management for drinking water.

PTEN Overexpression Alters Autophagy Levels and Slows Sodium Arsenite-Induced Hepatic Stellate Cell Fibrosis.

Exposure to inorganic arsenic remains a global public health problem. The liver is the main target organ, leading to arsenic-induced liver fibrosis. Phosphatase and tensin homology deleted on chromosome ten (PTEN) may participate in arsenic-induced liver fibrosis by regulating autophagy, but the exact mechanisms remain unclear.

A PTEN-Autophagy Risk Model for the Prediction of Prognosis and Immune Microenvironment in Hepatocellular Carcinoma.

Background: The clinical behavior and molecular mechanisms of hepatocellular carcinoma (HCC) are complex and highly variable, limiting the discovery of new targets and therapies in clinical research. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is one of the tumor suppressor genes. It is of great interest to discover the role of unexplored correlation among PTEN, the tumor immune microenvironment, and autophagy-related signaling pathways and to construct a reliable risk model for prognosis during HCC progression.