Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression.

Background: Nuclear translocation of several oncogenic proteins have previously been reported, but neither the translocation of doublecortin (DCX) nor the mechanism involved has been studied. DCX is a neuronal microtubule-associated protein (MAP) that is crucial for adult neurogenesis and neuronal migration and has been associated with poor prognosis in gliomas.

Methods: We probed DCX expression in different grades of glioma tissues and conventional cells via western blotting.