Biomechanical analysis of maxillary posterior three unit bridge supported misial straight implant and distal tilted implant.

Purpose: This study aims to investigate the stress distribution in bone tissue, implant, abutment, screw, and bridge restoration when the mesial implant is placed axially and the distal implant is inserted at varying angles in the posterior maxillary region with free-end partial dentition defects, using three-dimensional finite element analysis.

Materials And Methods: Cone-beam computed-tomography were utilized to create 3D reconstruction models of the maxilla. Stereolithography data of dental implants and accessories were used to design a three-unit full zirconia bridge for the maxillary model.

Evolution of Biological Hydroxyapatite Modification Strategy: Anti-Inflammation Approach Rescues the Calcium-NOD-Like Receptor-Inflammation Axis-Mediated Periodontal Redevelopment Failure.

Periodontal regenerative medicine is currently undergoing a paradigm shift from dissecting the healing process toward utilization of the developmental program. Biological hydroxyapatite (BHA), a major component of guided tissue regeneration, has long been optimized for inducing multidirectional differentiation of periodontal ligament cells (PDLCs). However, this approach runs counter to the redevelopment strategy.

Gingival fibroblast suppress the osteogenesis process mediated by bone substitute materials via WNT/β-catenin signaling pathway and .

Background: The regeneration of bone tissue is a critical challenge in oral and maxillofacial surgery, with the success of such procedures often depending on the ability to promote osteogenesis while managing the soft tissue environment. The role of gingival fibroblasts in modulating the osteogenic potential of mandible mesenchymal stem cells (MMSCs) mediated by bone substitute materials (BSMs) is not fully understood. This study aimed to investigate the impact of gingival fibroblasts on the osteogenic differentiation of MSCs in the presence of BSMs and to elucidate the underlying mechanisms, focusing on the WNT/β-catenin signaling pathway.

Pan-cancer and multi-omics analysis: NDUFA1 is a potential therapeutic target and prognostic marker for esophageal cancer.

Objectives: The study examined the NDUFA1 expression and its prognostic value in pan-cancer, especially in esophageal cancer (ESCA). Its carcinogenic effect on ESCA was further elucidated.

Materials And Methods: TCGA database was used to examine NDUFA1 expression and its prognostic value in 33 cancer types.

Precise multi-factor immediate implant placement decision models based on machine learning.

This study aims to explore the effect of implant apex design, osteotomy preparation, intraosseous depth and bone quality on immediate implant placement insertion torque and establish a more sophisticated decision model with multi-factor analysis based on machine learning for improving the success rate of immediate implant placement. Six implant replicas of each of the three implant systems with different implant apex design were placed in polyurethane foam block with different densities(soft, medium and hard) via two osteotomy preparation protocols (normal preparation and undersized preparation) at different implant intraosseous depths (3 mm, 5 mm and 7 mm). The insertion torque for each implant was recorded and subsequently analyzed using one-way and four-way ANOVA.

A biodegradable magnesium alloy promotes subperiosteal osteogenesis via interleukin-10-dependent macrophage immunomodulation.

In situ bone regeneration and vertical bone augmentation have been huge problems in clinical practice, always imposing a significant economic burden and causing patient suffering. Herein, MgZnYNd magnesium alloy rod implantation in mouse femur resulted in substantial subperiosteal new bone formation, with osteoimmunomodulation playing a pivotal role. Abundant macrophages were attracted to the subperiosteal new bone region and proved to be the most important regulation cells for bone regeneration.

Microarchitecture and Crystalline Composition: A Comprehensive Exploration of Salivary Gland Stones.

Objective: To investigate the microarchitecture and crystalline composition of sialoliths and to explore their formation mechanisms.

Methods: Sixty-six sialolith samples (51 from the submandibular glands and 15 from the parotid glands) were retrospectively collected. Their diameter and quality were measured.

Turn Hood into Good: Recycling Silicon from Mesoporous Silica Nanoparticles through Magnesium Modification to Lower Toxicity and Promote Tissue Regeneration.

Mesoporous silica nanoparticles (MSNs) have gained wide application as excellent carrier materials; however, their limited degradation in the biological system and potential chronic toxicity pose challenges to their clinical applications. Previous studies have focused on optimizing the elimination performance of MSNs; interestingly, silicon has been well-documented as an essential body component. Therefore, converting MSNs into a form readily utilizable by the organism is a way to turn waste into a valuable resource.

Maxillary Immediate Molar Implant Placement Into Palatal Root Socket: A Case Report of Two-Year Follow-Up.

The palatal root of the maxillary molar is the largest among the three roots; therefore, the direction of the palatal root extraction socket can serve as a choice for the implantation direction during immediate implant placement. By directly implanting the implant into the extraction socket of the palatal root of the maxillary molar, the procedure of immediate implantation of maxillary molars can be simplified, the treatment period can be shortened, costs can be reduced, surgical trauma can be minimized, and some significant risks and complications associated with sinus augmentation surgery can be avoided. This case report, with a two-year follow-up, details the process of immediate implant placement into the palatal root socket of the maxillary molar.

ICPNet: Advanced Maize Leaf Disease Detection with Multidimensional Attention and Coordinate Depthwise Convolution.

Maize is an important crop, and the detection of maize diseases is critical for ensuring food security and improving agricultural production efficiency. To address the challenges of difficult feature extraction due to the high similarity among maize leaf disease species, the blurring of image edge features, and the susceptibility of maize leaf images to noise during acquisition and transmission, we propose a maize disease detection method based on ICPNet (Integrated multidimensional attention coordinate depthwise convolution PSO (Particle Swarm Optimization)-Integrated lion optimisation algorithm network). Firstly, we introduce a novel attention mechanism called Integrated Multidimensional Attention (IMA), which enhances the stability and responsiveness of the model in detecting small speckled disease features by combining cross-attention and spatial channel reconstruction methods.

Duplex Fluorinated and Atomic Layer Deposition-Derived ZrO Coatings Improve the Corrosion Resistance and Mechanical Properties of Mg-2Zn-0.46Y-0.5Nd (wt.%) Alloy Plates and Screws.

This study investigated the corrosion resistance and mechanical properties of Mg-2Zn-0.46Y-0.5Nd (wt.

Effect of tissue fixatives on the corrosion of biomedical magnesium alloys.

In this work, the corrosion behavior of pure Mg, Mg3Ag, Mg6Ag, and MgZnYNd alloys in different fixatives (ethyl alcohol (EA), 85 % ethyl alcohol (85 % EA), 10 % neutral buffered formalin (10 % NBF), 4 % glutaric dialdehyde (4 % GD), and 4 % paraformaldehyde (4 % PFA)) was investigated to provide a valuable reference for the selection of fixatives during the histological evaluation of Mg implants. Through the hydrogen evolution test, pH test, and corrosion morphology and product characterization, it was found that corrosion proceeded slowest in the EA and 85 % EA groups, slightly faster in 4 % GD, faster in 10 % NBF, and fastest in 4 % PFA. After corrosion, the EA group surface remained unchanged, while the 85%EA group surface developed minor cracks and warping.

Visualized Enzyme-Activated Fluorescence Probe for Accurately Detecting β-Gal in Living Cells and BALB/c Nude Mice.

Colorectal cancer was one of the major malignant tumors threatening human health and β-Gal was recognized as a principal biomarker for primary colorectal cancer. Thus, designing specific and efficient quantitative detection methods for measuring β-Gal enzyme activity was of great clinical test significance. Herein, an ultrasensitive detection method based on Turn-on fluorescence probe (CS-βGal) was reported for visualizing the detection of exogenous and endogenous β-galactosidase enzyme activity.

Long-Term Temporospatial Complementary Relationship between Degradation and Bone Regeneration of Mg-Al Alloy.

The utilization of guided tissue regeneration membranes is a significant approach for enhancing bone tissue growth in areas with bone defects. Biodegradable magnesium alloys are increasingly being used as guided tissue regeneration membranes due to their outstanding osteogenic properties. However, the degradation rates of magnesium alloy bone implants documented in the literature tend to be rapid.

Inducing the "re-development state" of periodontal ligament cells via tuning macrophage mediated immune microenvironment.

Introduction: Periodontal regeneration, specifically the restoration of the cementum-periodontal ligament (PDL)-alveolar bone complex, remains a formidable challenge in the field of regenerative dentistry. In light of periodontal development, harnessing the multi-tissue developmental capabilities of periodontal ligament cells (PDLCs) and reinitiating the periodontal developmental process hold great promise as an effective strategy to foster the regeneration of the periodontal complex.

Objectives: This study aims to delve into the potential effects of the macrophage-mediated immune microenvironment on the "developmental engineering" regeneration strategy and its underlying molecular mechanisms.

Integrated Computing Accelerates Design and Performance Control of New Maraging Steels.

This paper mainly used database technology, machine learning, thermodynamic calculation, experimental verification, etc., on integrated computational materials engineering. The interaction between different alloying elements and the strengthening effect of precipitated phases were investigated mainly for martensitic ageing steels.

Cell-free immunomodulatory biomaterials mediated periodontal multi-tissue regeneration and their immunopathophysiological processes.

Cell-free biomaterials-inducing endogenous multi-tissue regeneration is very challenging and applying advanced immunomodulatory biomaterials can be an effective strategy to overcome it. In-depth knowledge of the immunopathophysiological mechanisms should be acquired before applying such an immunomodulation strategy. In this study, we implanted different immunoregulatory cell-free biomaterials into periodontal multi-tissue defects and showed that the outcome of multi-tissue regeneration is closely regulated by the immune reaction.

MiR-20a: a mechanosensitive microRNA that regulates fluid shear stress-mediated osteogenic differentiation via the BMP2 signaling pathway by targeting BAMBI and SMAD6.

Background: MicroRNAs (miRNAs) are crucial regulators of diverse biological and pathological processes. This study aimed to investigate the role of microRNA 20a (miR-20a) in fluid shear stress (FSS)-mediated osteogenic differentiation.

Methods: In the present study, we subjected osteoblast MC3T3-E1 cells or mouse bone marrow stromal cells (BMSCs) to single bout short duration FSS (12 dyn/cm for 1 hour) using a parallel plate flow system.

TiO Nanocoatings with Controllable Crystal Type and Nanoscale Topography on Zirconia Implants to Accelerate Bone Formation.

In dentistry, zirconia implants have emerged as a promising alternative for replacing missing teeth due to their superior aesthetic performance and chemical stability. To improve the osseointegration of zirconia implants, modifying their surface with hierarchical micro/nanotopography and bioactive chemical composition are two effective ways. In this work, a microscale topography was prepared on a zirconia surface using hydrofluoric acid etching, and then a 50 nm TiO nanocoating was deposited via atomic layer deposition (ALD).

Influences of Extrusion and Silver Content on the Degradation of Mg-Ag Alloys and .

Binary magnesium-silver (Mg-Ag) alloys were designed as antibacterial materials for biomedical implant applications. In the present study, we focused on the effects of extrusion (extrusion ratio (ER): 1, 7.1, and 72.

Feasibility and Efficacy of a Degradable Magnesium-Alloy GBR Membrane for Bone Augmentation in a Distal Bone-Defect Model in Beagle Dogs.

We explored the feasibility and efficacy of a degradable magnesium (Mg) alloy guided bone regeneration (GBR) in the treatment of bone defects after tooth extraction. A GBR membrane (MAR-Gide (MG)) was used to treat a mandibular second molar (M2M)-distal bone defect (DBD). In eight beagle dogs, bilateral mandibular second and fourth premolars were hemi-sected.

High-Temperature Oxidation Behavior of AlTiNiCuCo High-Entropy Alloys.

In this study, the high-temperature oxidation behavior of a series of AlTiNiCuCo high-entropy alloys (HEAs) was explored. The AlTiNiCuCo (x = 0.5, 0.

Modulating the cobalt dose range to manipulate multisystem cooperation in bone environment: a strategy to resolve the controversies about cobalt use for orthopedic applications.

The paradoxical effect of cobalt on biological processes has aroused controversy regarding the application of cobalt-based biomaterials in bone regeneration. Tuning the dose range of cobalt ions may be a valid strategy to resolve the controversies about cobalt use for orthopedic applications. Recent progress in bone biology has highlighted the effects of multisystem cooperation (especially of osteoimmune, skeletal, and vascular systems) on bone dynamics.

Suppressing MicroRNA-30b by Estrogen Promotes Osteogenesis in Bone Marrow Mesenchymal Stem Cells.

MicroRNAs (miRNAs) have been widely demonstrated to interact with multiple cellular signaling pathways and to participate in a wide range of physiological processes. Estradiol-17 (E2) is the most potent and prevalent endogenous estrogen that plays a vital role in promoting bone formation and reducing bone resorption. Currently, little is known about the regulation of miRNAs in E2-induced osteogenic differentiation.

A standardized rat burr hole defect model to study maxillofacial bone regeneration.

With high incidence rate and unique regeneration features, maxillofacial burr hole bone defects require a specially designed bone defect animal model for the evaluation of related bone regenerative approaches. Although some burr hole defect models have been developed in long bones or calvarial bones, the mandible has unique tissue development origins and regenerative environments. This suggests that the defect model should be prepared in the maxillofacial bone area.