Publications by authors named "Guannan Bai"
Article Synopsis
- Systemic lupus erythematosus (SLE) in children is a serious chronic condition, and a study assessed the health-related quality of life (HRQoL) for affected children and the well-being of their caregivers.
- The study involved 173 caregivers from a children's hospital, using specific questionnaires to measure children’s HRQoL and caregivers’ well-being. Results showed that children with SLE reported notably lower functioning in various areas compared to healthy peers, and 30.6% of caregivers experienced depressive symptoms.
- Key factors affecting children’s HRQoL included parental employment, financial stress, and body image changes, highlighting the interconnectedness of children's health and their caregivers' mental well-being.
Background: Pertussis resurgence has been reported worldwide in the past two decades. Pertussis is still endemic and difficult to control though with universal vaccination in children. The resurgence may be related to multiple variables, such as increased disease awareness and laboratory tests, waning of immunity following vaccination, and/or genetic mutations of Bordetella pertussis.
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- Streptococcus pyogenes, a common gram-positive bacterium, can cause rare brain abscesses in children, often without acute symptoms.
- A case was presented where a healthy child showed decreased muscle strength due to a GAS brain abscess, leading to successful surgical treatment and antibiotic therapy after isolating the bacteria.
- The study highlights the importance of recognizing mild symptoms of GAS brain abscesses for early diagnosis and treatment, which are critical for ensuring a good prognosis.
Article Synopsis
- The study aimed to assess the health-related quality of life (HRQoL) in children aged 2 to 18 diagnosed with idiopathic nephrotic syndrome (INS) in China, as well as the impact on their caregivers.
- It involved 181 children and used specific questionnaires to gather data on both children's and caregivers' HRQoL, employing statistical methods to analyze the findings.
- Results indicated that older children had poorer HRQoL compared to healthy peers, with several factors influencing their quality of life, and a notable correlation was found between the HRQoL of children and their caregivers.
Article Synopsis
- This study used functional near-infrared spectroscopy (fNIRS) to explore brain activity in children aged 7 to 15 with ADHD, focusing on those with and without learning disabilities or oppositional defiant disorder (ODD).
- Researchers categorized 165 medication-naive participants into four groups and monitored hemodynamic changes in specific brain regions while analyzing differences in brain activity using a metric called amplitude of low-frequency fluctuation (ALFF).
- Results showed that children with ADHD had higher ALFF values compared to healthy controls, and those with ADHD and learning disabilities had distinct patterns of brain activity, while ADHD with ODD did not show significant differences, suggesting ODD symptoms may be part of ADHD rather than a separate disorder.
Introduction: Neurofibromatosis type 1 (NF1) is a rare genetic disorder, with lack of evidence of disease burden in China. We aimed to describe the economic burden, health-related quality of life (HRQL), and caregiver burden of NF1 patients in China.
Methods: We conducted an online cross-sectional survey employing the China Cloud Platform for Rare Diseases, with 223 caregivers of NF1 pediatric patients (patients under 18), and 226 adult patients.
Article Synopsis
- * The increasing prevalence of MRMP, particularly noted in East Asia since 2000, results in extended hospitalization, poor treatment responses, and higher use of glucocorticoids and alternative antibiotics.
- * A group of 29 experts from China developed the first global consensus on diagnosing and treating pediatric MRMP pneumonia, emphasizing the importance of early identification and appropriate treatment strategies based on current evidence.
Article Synopsis
- A study was conducted to assess the prevalence of skin problems related to insulin pump use in children with type 1 diabetes in China, involving 461 participants from an online group.
- Results showed that about 66.8% of children experienced skin issues, including pigmentation changes, allergies, and infections, with significant factors identified being the caregiver's education level, existing skin allergies, and the specific brand of insulin pump used.
- The findings suggest that health education should incorporate these factors, alongside the typical focus areas, to improve care for children using insulin pumps.
Rheumatoid Arthritis is a more serious threatening to people and suitable for QOL measurement. A few specific QOL instruments are available without considering Chinese culture. The present study was aimed to develop and validate the Rheumatoid Arthritis Scale among the System of Quality of Life Instruments for Chronic Diseases (QLICD-RA V2.
View Article and Find Full Text PDFBackground: Bronchopulmonary dysplasia (BPD) is a major complication affecting the survival rate and long-term outcomes of preterm infants. A large, prospective, multicenter cohort study was conducted to evaluate early nutritional support during the first week of life for preterm infants with a gestational age < 32 weeks and to verify nutritional risk factors related to BPD development.
Methods: A prospective multicenter cohort study of very preterm infants was conducted in 40 tertiary neonatal intensive care units across mainland China between January 1, 2020, and December 31, 2021.
Article Synopsis
- The study investigated the growth patterns of full-term small-for-gestational-age (SGA) infants in East China from birth to 3 years old, noting their risk for impaired growth and development.
- Researchers followed 816 SGA infants, measuring weight and length at several intervals and identified catch-up growth rates of around 42-52% by 36 months, with variations between boys and girls.
- The findings reveal a low catch-up growth rate and distinct growth trajectories by gender, highlighting the need for healthcare professionals to monitor these infants closely to support their health development.
Article Synopsis
- - The study examines how bleeding disorders (BDs) affect health-related quality of life (HRQoL) in children and their caregivers, highlighting the need for HRQoL measurement to identify areas needing support and evaluate new treatments.
- - A scoping review of 53 articles revealed that most research focuses on school-aged boys with hemophilia from Europe and North America, with a significant gap in studies involving younger children and different types of bleeding disorders.
- - The conclusion stresses the importance of expanding HRQoL research to include a wider range of patients and better statistical methods, as current studies often combine various disorders and utilize multiple questionnaires that limit comparability.
Background: Steroid-sensitive nephrotic syndrome (SSNS) accounts for approximately 80% of cases of nephrotic syndrome. The involvement of aberrant lipid metabolism in early SSNS is poorly understood, warranting further investigation. This study aimed to explore alterations in lipid metabolism associated with SSNS pathogenesis.
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- - The study analyzed RSV infection patterns in Chinese children aged 0-18 during different phases of the COVID-19 pandemic, including before, during, and after restrictions were lifted, using data from 123,623 patients from January 2019 to June 2023.
- - Among the 3875 children diagnosed with RSV (3.13%), the highest infection rates were found in newborns (0-28 days) and the virus was most prevalent in winter, with an observed increase in infections post-pandemic compared to during the pandemic.
- - The research highlighted a broader age range for susceptibility to RSV after COVID-19 restrictions were lifted (0-3.5 years), signaling a need for heightened awareness among health professionals and
Bronchopulmonary dysplasia (BPD) is the most common complication of prematurity involving both pre- and post-natal factors. A large, prospective, longitudinal cohort study was conducted to determine whether inflammation-related factors are associated with an increased risk of BPD in preterm infants who were born at a gestational age < 32 weeks, < 72 h after birth and respiratory score > 4. The study included infants from 25 participating hospitals in China between March 1, 2020 and March 31, 2022.
View Article and Find Full Text PDFObjectives: The present study aimed to evaluate the characteristics of functional brain connectivity in the resting state in children with attention deficit hyperactivity disorder (ADHD) and to assess the association between the connectivity and inhibition function using near-infrared spectroscopy (NIRS).
Methods: In total, 34 children aged 6-13 diagnosed with ADHD were recruited from Hangzhou Seventh People's Hospital. In comparison, 37 healthy children were recruited from a local primary school as controls matched by age and sex.
Endometrial cancer (EC) is a common malignant tumor that lacks any therapeutic target and, in many cases, recurrence is the leading ca use of morbidity and mortality in women. Widely known EC has a strongly positive correlation with abnormal lipid metabolism. Squalene epoxidase (SQLE), a crucial enzyme in the cholesterol synthesis pathway regulating lipid metabolic processes has been found to be associated with various cancers in recent years.
View Article and Find Full Text PDFIntroduction: Williams syndrome (WS) is a rare genetic disorder that impacts multiple systems and may cause developmental delays. These medical and developmental issues impose a heavy burden on affected children and their families. However, there was no study on children's health-related quality of life (HRQoL) with WS and only two studies about family quality of life globally.
View Article and Find Full Text PDFBackground/aims: Diabetic retinopathy is the most common eye disease that causes blindness in the working population. Neurodegeneration is the early sign of diabetic retinopathy, but no drug has been approved for delaying or reversing retinal neurodegeneration. Huperzine A, a natural alkaloid isolated from Huperzia serrata, displays neuroprotective and antiapoptotic effects in treating neurodegenerative disorders.
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- The study analyzed norovirus infections in 5,564 patients under 18 with acute diarrhea from December 2020 to November 2022, finding that 25.9% tested positive for the virus.
- The prevalence of norovirus was highest in winter (35.1%) and significantly lower in 2022 (35.9%) compared to 2021 (53.7%).
- The highest infection rates were among children aged 1-3 years, particularly at 1.5 years, indicating a consistent pattern during the COVID-19 pandemic similar to pre-pandemic levels.
Predicting metastasis at initial diagnosis and radiotherapy effectiveness in patients with metastatic osteosarcoma.
J Cancer Res Clin Oncol
September 2023
Osteosarcoma is a primary malignant bone tumor affecting mostly children and adolescents. The overall 10 year survivals of patients with metastatic osteosarcoma are typically less than 20% in the literature and remain concerning. We aimed to develop a nomogram for predicting the risk of metastasis at initial diagnosis in patients with osteosarcoma and evaluate the effectiveness of radiotherapy in patients with metastatic osteosarcoma.
View Article and Find Full Text PDFRisk factors for re-dislocation after closed reduction in children with developmental dysplasia of the hip.
Zhejiang Da Xue Xue Bao Yi Xue Ban
August 2022
Objective: To investigate the risk factors for re-dislocation after the closed reduction in children with developmental dysplasia of the hip (DDH).
Methods: The clinical data of 88 children aged ≤ 18 months with DDH (103 hips) who were treated with adductor muscle relaxation + closed reduction + plaster fixation at the Children's Hospital, Zhejiang University School of Medicine from January 2015 to December 2017, were retrospectively analyzed. According to the diagnostic criteria of hip dislocation, patients were divided into two groups: reduction group and re-dislocation group.
Background: Nurturing care is necessary for optimal early childhood development. This study aimed to investigate the prevalence of parental risks in rural East China and assess their impacts on early development in children younger than three years old.
Methods: This community-based cross-sectional survey was conducted among 3852 caregiver-child pairs in Zhejiang Province from December 2019 to January 2020.