Publications by authors named "Guanlin Li"

The concurrent environmental challenges of invasive species and soil microplastic contamination increasingly affect agricultural ecosystems, yet their combined effects remain underexplored. This study investigates the interactive impact of the legacy effects of Canada goldenrod ( L.) invasion and soil microplastic contamination on wheat ( L.

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Despite remarkable advancements in the organic synthesis field facilitated by the use of machine learning (ML) techniques, the prediction of reaction outcomes, including yield estimation, catalyst optimization, and mechanism identification, continues to pose a significant challenge. This challenge arises primarily from the lack of appropriate descriptors capable of retaining crucial molecular information for accurate prediction while also ensuring computational efficiency. This study presents a successful application of ML for predicting the performance of Ir-catalyzed allylic substitution reactions.

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Inflammatory cells infiltration in the cerebrospinal fluid is a hallmark of severe enterovirus 71 (EV71) infection, but which type of immune cells are critical for severe EV71 infection remains unclear. Here, we observe that both neutrophils and macrophages are increased in the brains of patients and mice with severe EV71 infection, and the depletion of neutrophils but not macrophages results in a marked enhancement of survival of EV71-infected mice. Furthermore, CCR1/3 may play an important role in CCL3 facilitating the accumulation of neutrophils in the brains of patients.

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The increasing salinity of agricultural lands highlights the urgent need to improve salt tolerance in crops, a critical factor for ensuring food security. Epigenetic mechanisms are pivotal in plant adaptation to salt stress. This review elucidates the complex roles of DNA methylation, histone modifications, histone variants, and non-coding RNAs in the fine-tuning of gene expression in response to salt stress.

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  • * Out of 10,210 SCA cases, most (85.6%) were non-shockable; both shockable and non-shockable cases peaked in the morning (08:00 - 11:59) and decreased significantly during the early morning hours (00:00 - 03:59).
  • * The findings suggest that there is a distinct daily rhythm in SCA occurrences, indicating that increased focus on first-aid and resuscitation resources is essential during morning hours in the community.
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  • Heavy metal contamination, particularly arsenic and cadmium, poses a significant threat to crop production and global food security, prompting the need for effective remediation methods.
  • Traditional remediation methods face limitations due to environmental risks and high costs, leading researchers to explore calcium and calcium-based nano-formulations as potential solutions to reduce toxicity in soil.
  • The review examines the effects of arsenic and cadmium on crop health, evaluates the efficacy of calcium treatments compared to conventional techniques, and discusses future directions and ecological implications for sustainable agricultural practices.
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Environmental contamination by cadmium (Cd), a highly toxic heavy metal, poses significant health risks to plants and humans. Biochar has been effectively used to promote plant growth and productivity under Cd stress. This study presents an innovative application of biochar derived from the invasive weed Parthenium hysterophorus to promote plant growth and productivity under Cd stress.

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The escalating threat of heavy metal and metalloid stress on plant ecosystems requires innovative strategies to strengthen plant resilience and ensure agricultural sustainability. This review provides important insights into the advanced epigenetic pathways to improve plant tolerance to toxic heavy metals and metalloid stress. Epigenetic modifications, including deoxyribonucleic acid (DNA) methylation, histone modifications, and small ribonucleic acid (RNA) engineering, offer innovative avenues for tailoring plant responses to mitigate the impact of heavy metal and metalloid stress.

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Plant community succession can impact greenhouse gas (GHG) emissions from the soil by altering the soil carbon and nitrogen cycles. However, the effects of community landscape diversity on soil GHG emissions have rarely been fully understood. Therefore, this study investigated how plant landscape diversity, structure type, and species composition, affect soil GHG emissions in a riparian zone.

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Image harmonization seeks to transfer the illumination distribution of the background to that of the foreground within a composite image. Existing methods lack the ability of establishing global-local pixel illumination dependencies between foreground and background of composite images, which is indispensable for sharp and color-consistent harmonized image generation. To overcome this challenge, we design a novel Simple Hybrid CNN-Transformer Network (SHT-Net), which is formulated into an efficient symmetrical hierarchical architecture.

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  • Carbonic anhydrase (CA) is essential for carbon dioxide capture, and this study developed a bioinspired zinc metal-organic framework (Zn-MOF) to enhance CO hydration.
  • The synthesized Zn-MOF showed effective catalytic activity for CO hydration and ester hydrolysis, with amino groups boosting its esterase activity significantly compared to existing materials.
  • The Zn-MOF proved to retain a high percentage of its activity after multiple uses and displayed impressive stability under hydrothermal conditions, suggesting its practical applications in industrial CO capture processes.
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The precise control of and configurations of the carbon-carbon double bond in alkene synthesis has long been a fundamental challenge in synthetic chemistry, even more pronounced when simultaneously striving to achieve enantioselectivity [(,), (,), (,), (,)]. Moreover, enantiopure non-natural α-amino acids are highly sought after in organic and medicinal chemistry. In this study, we report a ligand-controlled stereodivergent synthesis of non-natural α-quaternary amino acids bearing trisubstituted alkene moieties in high yields with excellent enantioselectivity and / selectivities.

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Disentangling microbial community diversity patterns and assembly mechanisms is critical for understanding ecological processes and evaluating biogeochemical cycling in ecosystems. However, the diversity patterns and assembly mechanism of the microbial communities in the epipelagic waters in the northeastern Indian Ocean (NEIO) on the spatial scale are still unclear. In this study, we investigated the spatial dynamics, geographic distribution pattern, and assembly process of the bacterial community using 532 samples collected from the epipelagic waters in the NEIO during the northeast monsoon.

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Heavy metals (HMs) pollution is a globally emerging concern. It is difficult to cost-effectively combat such HMs polluted soil environments. The efficient remediation of HMs polluted soil is crucial to protect human health and ecological security that could be carried out by several methods.

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Tri(1,3-dichloro-2-propyl)phosphate (TDCPP) is one of the most widely used organophosphorus flame retardants in consumer products. TDCPP has been confirmed to be neurotoxic, but its mechanism has not been clarified and may be related to mitophagy. AMBRA1 can promote neurological autophagy, but whether AMBRA1 is involved in the mechanism of TDCPP-induced neurotoxicity has not been elucidated.

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  • The study highlights the need for advanced fluorescent indicators due to the presence of various substances in the environment, rendering single-function sensors insufficient.
  • It introduces a new ratiometric dual-emission fluorescent sensor (Probe CP), designed to detect both HClO and HS by using a special chemical structure that allows for a clear fluorescence change based on the presence of these substances.
  • The sensor demonstrates high specificity and sensitivity, with low detection limits and quick response times, making it useful for biological applications, including studies on alcohol-induced liver damage in mice and in cellular environments.
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Cancer immunotherapy holds significant promise for addressing diverse malignancies. Nevertheless, its efficacy remains constrained by the intricate tumor immunosuppressive microenvironment. Herein, a light-triggered nanozyme Fe-TCPP-R848-PEG (Fe-MOF-RP) was designed for remodeling the immunosuppressive microenvironment.

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Detecting the underlying human values within arguments is essential across various domains, ranging from social sciences to recent computational approaches. Identifying these values remains a significant challenge due to their vast numbers and implicit usage in discourse. This study explores the potential of emotion analysis as a key feature in improving the detection of human values and information extraction from this field.

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The prevalence of offensive content on online communication and social media platforms is growing more and more common, which makes its detection difficult, especially in multilingual settings. The term "Offensive Language" encompasses a wide range of expressions, including various forms of hate speech and aggressive content. Therefore, exploring multilingual offensive content, that goes beyond a single language, focus and represents more linguistic diversities and cultural factors.

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Heavy metal pollution threatens plant growth and development as well as ecological stability. Here, we synthesize current research on the interplay between plants and their microbial symbionts under heavy metal stress, highlighting the mechanisms employed by microbes to enhance plant tolerance and resilience. Several key strategies such as bioavailability alteration, chelation, detoxification, induced systemic tolerance, horizontal gene transfer, and methylation and demethylation, are examined, alongside the genetic and molecular basis governing these plant-microbe interactions.

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Both alien plant invasions and soil microplastic pollution have become a concerning threat for terrestrial ecosystems, with consequences on the human well-being. However, our current knowledge of microplastic effects on the successful invasion of plants remains limited, despite numerous studies demonstrating the direct and indirect impacts of microplastics on plant performance. To address this knowledge gap, we conducted a greenhouse experiment involving the mixtures of soil and low-density polyethylene (LDPE) microplastic pellets and fragments at the concentrations of 0, 0.

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It is urgent to develop an alternative dynamic therapy-based method to overcome the limited efficacy of traditional therapy methods for bladder cancer and the damage caused to patients. Sonodynamic therapy (SDT) has the advantages of high tissue penetration, high spatiotemporal selectivity, and being non-invasive, representing an emerging method for eradicating deep solid tumors. However, the effectiveness of SDT is often hindered by the inefficient production of reactive oxygen species and the nondegradability of the sonosensitizer.

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Sonodynamic therapy (SDT) is applied to bladder cancer (BC) given its advantages of high depth of tissue penetration and nontoxicity due to the unique anatomical location of the bladder near the abdominal surface. However, low electron-hole separation efficiency and wide bandgap of sonosensitizers limit the effectiveness of SDT. This study aims to develop a TiO-Ru-PEG Schottky heterojunction sonosensitizer with high electron-hole separation and narrow bandgap for SDT in BC.

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Invasive alien plants (IAPs) pose significant threats to native ecosystems and biodiversity worldwide. However, the understanding of their precise impact on soil carbon (C) dynamics in invaded ecosystems remains a crucial area of research. This review comprehensively explores the mechanisms through which IAPs influence soil C pools, fluxes, and C budgets, shedding light on their effects and broader consequences.

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  • Antisense oligonucleotides (ASOs) were the first to successfully target and reduce mutant SOD1 expression in amyotrophic lateral sclerosis (ALS) therapy.
  • Short interfering RNAs (siRNAs) also offer a gene-silencing mechanism but faced delivery challenges to the central nervous system (CNS).
  • The study introduces a new siRNA-ACO conjugate that enhances delivery to CNS tissues, showing promising results in slowing ALS progression and improving motor function in SOD1 mice.
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