pERK transition-induced directional mode switching promotes epithelial tumor cell migration.

Increasing evidence suggests that tumor cells exhibit extreme plasticity in migration modes in order to adapt to microenvironments. However, the underlying mechanism for governing the migration mode switching is still unclear. Here, we revealed that epithelial tumor cells could develop a stable directional mode driven by hyperactivated ERK activity.

Mechanism of the Change in the Intestinal Microbiota of C-Strain (Lepidoptera: Noctuidae) after an Interspecific Transference between Rice and Corn.

(J.E.Smith) (Lepidoptera: Noctuidae) was first found in 2019 in Yunnan, China, and it was characterized as a corn strain; it was also found on rice strains there, and it damages rice in China, but little is known about the effect of host plant transfer on the intestinal microbiota and the activities of detoxification enzymes in the C-strain (corn strain) .

Comparative Transcriptome Analysis of Defense Response of Potato to Infestation.

The potato tuber moth (PTM), Zeller (Lepidoptera: Gelechiidae), is one of the most destructive pests of potato crops worldwide. Although it has been reported how potatoes integrate the early responses to various PTM herbivory stimuli by accumulatively adding the components, the broad-scale defense signaling network of potato to single stimuli at multiple time points are unclear. Therefore, we compared three potato transcriptional profiles of undamaged plants, mechanically damaged plants and PTM-feeding plants at 3 h, 48 h, and 96 h, and further analyzed the gene expression patterns of a multitude of insect resistance-related signaling pathways, including phytohormones, reactive oxygen species, secondary metabolites, transcription factors, MAPK cascades, plant-pathogen interactions, protease inhibitors, chitinase, and lectins, etc.

Adaptive fixed-time consensus for stochastic multi-agent systems with uncertain actuator faults.

In this paper, we study the adaptive fixed-time consensus control for stochastic multi-agent systems (SMASs) with uncertain actuator faults. Firstly, a fully distributed adaptive consensus protocol and an adaptive fault-tolerant consensus protocol are proposed, respectively, to ensure that the fixed-time consensus of SMASs with actuator faults can be reached. Secondly, an adaptive fault-tolerant containment consensus protocol is further proposed for the SMASs by leveraging the signum function, and this protocol can effectively solve the containment consensus in the unbalanced communication network.

On the averaging principle for stochastic differential equations involving Caputo fractional derivative.

In this paper, we investigate the averaging principle for Caputo-type fractional stochastic differential equations driven by Brownian motion. Different from the approach of integration by parts or decomposing integral interval to deal with the estimation of integral involving singular kernel in the existing literature, we show the desired averaging principle in the sense of mean square by using Hölder inequality via growth conditions on the nonlinear stochastic term. Finally, a simulation example is given to verify the theoretical results.

A multifunctional enzyme portfolio for α-chaconine and α-solanine degradation in the gut bacterium S2 encoded in a trisaccharide utilization locus.

Steroidal glycoalkaloids (SGAs) are secondary metabolites commonly found in members of the family Solanaceae, including potatoes, and are toxic to pests and humans. The predominant SGAs in potato are α-chaconine and α-solanine. We previously reported that S2, a gut bacterium of the pest (potato tuber moth), can degrade α-chaconine and α-solanine in potatoes, which can improve the fitness of to feed on potatoes with a high content of toxic SGAs.

Instar Determination for the Tomato Leafminer Tuta absoluta (Lepidoptera: Gelechiidae) Using the Density-Based OPTICS Clustering Algorithm.

The tomato leafminer Tuta absoluta (Meyrick) is one of the most harmful pests of solanaceous crops. Its larval morphological characteristics are similar, making the distinguishing between different larval instars difficult. Accurate identification of T.

Glutamicibacter halophytocola-mediated host fitness of potato tuber moth on Solanaceae crops.

Background: The potato tuber moth (PTM), Phthorimaea operculella (Zeller) (Lepidoptera: Gelechiidae), is a destructive pest of Solanaceae crops worldwide. α-solanine and α-chaconine are toxic steroidal glycoalkaloids (SGAs) in Solanaceae crops and are most abundant in potatoes (Solanum tuberosum L.), accounting for more than 95% of the total SGAs.

Targeting Mitochondrial Metabolism and RNA Polymerase POLRMT to Overcome Multidrug Resistance in Cancer.

Clinically, the prognosis of tumor therapy is fundamentally affected by multidrug resistance (MDR), which is primarily a result of enhanced drug efflux mediated by channels in the membrane that reduce drug accumulation in tumor cells. How to restore the sensitivity of tumor cells to chemotherapy is an ongoing and pressing clinical issue. There is a prevailing view that tumor cells turn to glycolysis for energy supply due to hypoxia.

Midgut microbiota diversity of potato tuber moth associated with potato tissue consumed.

Background: The potato tuber moth (PTM), Phthorimaea operculella (Zeller), is a worldwide pest that feeds on both the leaves and tubers of potato plants. PTM larvae can digest leaves, or tubers, resulting in serious damage to potato plants in the field and potato tubers in storage. To understand how midgut bacterial diversity is influenced by the consumption of these two tissue types, the symbiotic bacteria in the potato-feeding PTM midgut and the endophytic bacteria of potato tissues were analyzed.

The Time-Concentration-Mortality Responses of Western Flower Thrips, Frankliniella occidentalis, to the Synergistic Interaction of Entomopathogenic Fungus Metarhizium flavoviride, Insecticides, and Diatomaceous Earth.

Western flower thrips (WFT), Frankliniella occidentalis (Pergande), is a highly invasive pest which is harmful to many cash crops globally and resistant to various insecticides. Entomopathogenic fungi (EPF), as biological control agents, have demonstrated a good control effect on WFT. The aim of this study was to evaluate the synergistic and pathogenicity efficacy of the fungal strain WSWL51721 when distributed with diatomaceous earth (DE) and the active ingredient imidacloprid using four bioassay methods against adult and second instar larvae of WFT.