Hyperthermotherapy enhances antitumor effect of 5-aminolevulinic acid-mediated sonodynamic therapy with activation of caspase-dependent apoptotic pathway in human glioma.

Sonodynamic therapy (SDT) has shown great potential as an approach for cancer treatment, and hyperthermotherapy (HT) is also a promising cancer therapy. Here, we investigate whether HT could improve the efficacy of SDT and to make a preliminary exploration on potential mechanism. Xenograft tumor was established in nude mice model, and SNB19 and U87MG glioma cell lines were utilized for in vitro experiment.

Double plasmonic nanodisks design for electromagnetically induced transparency and slow light.

An analog of plasmonic system for electromagnetically induced transparency (EIT), in which a small nanodisk with a big side-coupled-nanodisk is directly coupled to the metal-insulator -metal (MIM) waveguide, has been proposed and investigated theoretically and numerically. When the resonant frequencies of the two nanodisks differ not too much, a powerful EIT-like effect can be obtained, and the transparency window can be easily tuned by adjusting the radii of the two nanodisks. The plasmonic device can be used as a high-performance EIT-like filter with transmission over 80% and full width at half-maximum (FWHM) less than 30nm, besides, the novel structure shows a high group index over 355.

Asymmetric band-pass plasmonic nanodisk filter with mode inhibition and spectrally splitting capabilities.

A compact wavelength band-pass filter based on metal-insulator-metal (MIM) nanodisk cavity is proposed and numerically investigated by using Finite-Difference Time-Domain (FDTD) simulations. It is found that the transmission characteristics of the filter can be easily adjusted by changing the geometrical parameters of the radius of the nanodisk and coupling distance between the nanodisk and waveguide. By extending the length of input/output waveguides, the filter shows the resonant mode inhibition function.