CircRAPGEF5 acts as a modulator of RAS/RAF/MEK/ERK signaling during colorectal carcinogenesis.

Mutations in oncogenes such as , and promote the growth and survival of tumors, while excessive RAS/RAF/MEK/ERK activation inhibits tumor growth. In this study we examined the precise regulatory machinery that maintains a moderate RAS/RAF/MEK/ERK pathway activation during CRC. Here, using bioinformatic analysis, transcriptomic profiling, gene silencing and cellular assays we discovered that a circular RNA, circRAPGEF5, is significantly upregulated in KRAS mutant colorectal cancer (CRC) cells.

Polyphenolic Nanomedicine Regulating Mitochondria REDOX for Innovative Cancer Treatment.

Cancer remains a highly lethal disease globally. The approach centered on REDOX-targeted mitochondrial therapy for cancer has displayed notable benefits. Plant polyphenols exhibit strong REDOX and anticancer properties, particularly by affecting mitochondrial function, yet their structural instability and low bioavailability hinder their utility.

Biological and physiological effects in Bemisia tabaci feeding on tomatoes endophytically colonized by Beauveria bassiana.

Background: Entomopathogenic fungi (EPF) treatment of plants may affect the survival and feeding preferences of herbivorous pests. However, comprehensive studies on the fitness across their entire life cycle, feeding behavior, and physiological changes in herbivores consuming EPF-treated plants within the tripartite interactions of EPF, plants, and pests are still limited. In this study, we utilized life tables, electrical penetration graph (EPG), and metabolomics to uncover the biological and physiological characteristics of Bemisia tabaci on tomato plants inoculated with Beauveria bassiana through root irrigation.

Intraguild Prey Served as Alternative Prey for Intraguild Predators in a Reciprocal Predator Guild between and .

The predatory mites (Hughes) and the predatory thrips (Priesner) are known as potential biocontrol agents for the two-spotted spider mite (Koch). These two predator species occur simultaneously on crops in agricultural ecosystems and are proved to be involved in life-stage specific intraguild predation. The intraguild prey may play a role in securing the persistence of the intraguild predators during food shortage periods.

Preparation of Micron-Sized TS-1 Spherical Membrane Catalysts and Their Performance in the Epoxidation of Chloropropene.

Titanium silica (TS-1) membrane catalysts grown on the surfaces of spherical substrates can both exploit the high catalytic performance and facilitate their separation from products after the reaction. In this work, a simple static crystallization method was used to perform the in situ construction of a TS-1 membrane on the surfaces of micron-sized spherical carriers. The shortcomings of the TS-1 membrane under static crystallization conditions were overcome by in situ dynamic crystallization, and the effect of rotation speed on the formation of the molecular sieve membrane was investigated.

Two Regional Deployment Algorithms of Distributed GNSS Forwarding Spoofer for Multiple Receiver Sensors.

Global navigation satellite system (GNSS) spoofing technology is an effective way to protect sensitive facilities and control foreign objects. To realize effective distributed GNSS forwarding spoofing for multiple receiver sensors in the area, the following research work is carried out: first, the GNSS forwarding spoofing model is established, including a forwarding spoofing mathematical model and an asynchronous traction spoofing method; second, the function scope of forwarding spoofing is fully evaluated; third, two forwarding spoofer area deployment algorithms for multi-spoofer multi-target (MSMT) are proposed-the multi-target same-point spoofing algorithm (MSPSA) is suitable for the same-point spoofing of multiple receiver sensors, and the multi-target different-point spoofing algorithm (MDPSA) is suitable for the different-point spoofing of multiple receiver sensors; and four, the experimental tests of MSPSA and MDPSA for MSMT were carried out. The experimental results show that MSPSA and MDPSA can respectively give the most appropriate deployment scheme of spoofing according to the various needs of the spoofer.

Prey life stages modulate effects of predation stress on prey lifespan, development, and reproduction in mites.

The non-consumptive effects of predator-induced stress can influence a variety of life-history traits. Many previous studies focused only on short-term effects such as development and reproductive rates. Recent studies have showed that long-term predation stress (given during the whole life of the prey) and short-term predation stress (provided during the immature stage of the prey) could generate completely opposite results: the former could decrease lifespan, whereas the later could increase lifespan.

A New GNSS Spoofing Signal Power Control Algorithm for Receiver Sensors in Acquisition Phase and Subsequent Control.

Satellite navigation spoofing technology has become a hotspot of interference technology research because of its significant threat and high concealment. In a spoofing scenario, suppressive interference is typically used to ensure that the target receiver sensor is in the unlocked and reacquisition state, and then spoofing is implemented. This method has a high feasibility, and the power of the spoofing signal affects the concealment and efficiency of spoofing.

A Slowly Varying Spoofing Algorithm on Loosely Coupled GNSS/IMU Avoiding Multiple Anti-Spoofing Techniques.

When satellite navigation terminal sensors encounter malicious signal spoofing or interference, if attention is not paid to improving their anti-spoofing ability, the performance of the sensors will be seriously affected. The global navigation satellite system (GNSS) spoofing has gradually become a research hotspot of the jammer because of its great harm and high concealment. In the face of more and more sensors coupling GNSS and inertial measurement unit (IMU) to varying degrees and configuring a variety of anti-spoofing techniques to effectively detect spoofing, even if the spoofer intends to gradually pull the positioning results, if the spoofing strategy is unreasonable, the parameters of the coupled filter output and spoofing observation measurement will lose their rationality, which will lead to the spoofing being detected.

An Improved BeiDou-2 Satellite-Induced Code Bias Estimation Method.

Different from GPS, GLONASS, GALILEO and BeiDou-3, it is confirmed that the code multipath bias (CMB), which originate from the satellite end and can be over 1 m, are commonly found in the code observations of BeiDou-2 (BDS) IGSO and MEO satellites. In order to mitigate their adverse effects on absolute precise applications which use the code measurements, we propose in this paper an improved correction model to estimate the CMB. Different from the traditional model which considering the correction values are orbit-type dependent (estimating two sets of values for IGSO and MEO, respectively) and modeling the CMB as a piecewise linear function with a elevation node separation of 10°, we estimate the corrections for each BDS IGSO + MEO satellite on one hand, and a denser elevation node separation of 5° is used to model the CMB variations on the other hand.

Kukoamine A attenuates insulin resistance and fatty liver through downregulation of Srebp-1c.

Nonalcoholic fatty liver disease (NAFLD) refers to a pathological condition of hepatic steatosis. Insulin resistance is believed to be the key mechanism mediating initial accumulation of fat in the liver, resulting in hepatic steatosis. Kukoamine A (KuA), a spermine alkaloid, is a major bioactive component extracted from the root barks of Lycium chinense (L.