Publications by authors named "Guangxiang Si"
Prior research has highlighted the reduction of iron oxide nanoparticle (IONPs) sizes to the "ultra-small" dimension as a pivotal approach in developing T-MRI contrast agents, and the enhancement in T contrast performance with the reducing size is usually attributed to the increased specific surface area and weakened magnetization. Nonetheless, as the size decreases, the variation in surface defects, particularly oxygen vacancy (V) defects, significantly impacts the T imaging efficacy. In this study, the V on IONPs is meticulously investigated through XPS, Raman, and EPR spectroscopy.
View Article and Find Full Text PDFContrast-enhanced magnetic resonance imaging (CE-MRI) is a pivotal tool for global disease diagnosis and management. Since its clinical availability in 2009, the off-label use of ferumoxytol for ferumoxytol-enhanced MRI (FE-MRI) has significantly reshaped CE-MRI practices. Unlike MRI that is enhanced by gadolinium-based contrast agents, FE-MRI offers advantages such as reduced contrast agent dosage, extended imaging windows, no nephrotoxicity, higher MRI time efficiency and the capability for molecular imaging.
View Article and Find Full Text PDFTherapeutic cancer vaccines offer the greatest advantage of enhancing antigen-specific immunity against tumors, particularly for immunogenic tumors, such as melanoma. However, clinical responses remain unsatisfactory, primarily due to inadequate T cell priming and the development of acquired immune tolerance. A major obstacle lies in the inefficient uptake of antigen by peripheral dendritic cells (DCs) and their migration to lymph nodes for antigen presentation.
View Article and Find Full Text PDFBackground: Currently, noninvasive arteriography for the diagnosis of coronary artery disease is clinically limited to the computed tomography scanning, where patients have to be exposed to the radiation and risks associated with iodinated contrast. We aimed to investigate the diagnostic performance and safety of a novel ferumoxytol-enhanced coronary magnetic resonance angiography (CMRA) in patients with suspected coronary artery disease.
Methods: Thirty patients, 19 males, with a median age of 63 years old, and 17 with renal insufficiency, who were scheduled for invasive coronary angiography, were enrolled.
Article Synopsis
- - Labeling mesenchymal stem cells (MSCs) with superparamagnetic iron oxide nanoparticles (SPIONs), particularly ferumoxytol, offers a promising way to track these cells in MRI for tissue repair.
- - Traditional methods of labeling MSCs have limitations due to the need for additional reagents or magnetic fields, but a new approach using biomimetic hydrogels allows for effective magnetic labeling without these drawbacks.
- - This innovative labeling technique maintains the overall health and properties of MSCs, as the ferumoxytol is found in the extracellular matrix rather than the cells themselves, suggesting strong potential for clinical applications in MRI tracking after transplantation.