Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity.

Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity, safeguarding receptor activation, and facilitating amplification of signal transduction across the cellular membrane. However, cell-surface antigen-induced multimerization (dubbed AIM herein) has not yet been consciously leveraged in chimeric antigen receptor (CAR) engineering for enriching T cell-based therapies. We co-developed ciltacabtagene autoleucel (cilta-cel), whose CAR incorporates two B-cell maturation antigen (BCMA)-targeted nanobodies in tandem, for treating multiple myeloma.

Interaction between ω-6 fatty acids intake and blood cadmium on the risk of low cognitive performance in older adults from National Health and Nutrition Examination Survey (NHANES) 2011-2014.

Background: Identifying preventable diets and environmental exposure is essential to ensuring the health of the aging population. This study evaluated the interaction effect between blood cadmium and ω-6 fatty acids intake on low cognitive performance in Americans.

Method: The data of this cross-sectional study were obtained from the 2011-2012 and 2013-2014 National Health and Nutritional Examination Survey (NHANES).

Withaferin A protects against spinal cord injury by inhibiting apoptosis and inflammation in mice.

Context: Withaferin A (WFA) exhibits diverse pharmaceutical applications on human diseases, including rheumatoid arthritis, cancers and microbial infection.

Objective: We evaluated the neuroprotective role of WFA using a mouse model of spinal cord injury (SCI).

Materials And Methods: BALB/c mice were administrated 10 mg/kg of WFA.

[Repair and reconstruction of femoral pseudoaneurysm caused by drug injection].

Objective: To evaluate repair and reconstruction of the femoral pseudoaneurysm caused by drug injection.

Methods: From May 2000 to May 2005, 15 cases of femoral pseudoaneurysm caused by drug injection underwent operation treatment. All patients were male, aging 20-36 years.

[Repair the infra-orbital defect with a rotation flap after basal cell carcinoma resection].

Objective: To explore the method repairing the infra-orbital defect after basal cell carcinoma resection.

Method: A facial rotation flap was applied to repair the infra-orbital defects from tumor resection in 28 cases.

Result: All defects were repaired by this one-stage method, which avoided skin graft, shortened the operation time and minimized the operation trauma.