Nucleic acid direct delivery to fibroblasts: a review of nucleofection and applications.

The fibroblast is one of the ideal target cell candidates for cell-based gene therapy approaches to promote tissue repair. Gene delivery to fibroblasts by viral transfection has been confirmed to have high transfection efficiency. However, in addition to immunogenic effects of viruses, the random integration of viral genes may damage the genome, affect the cell phenotype or even cause cancerous mutations in the transfected cells.

A Formation Control Method for AUV Group Under Communication Delay.

This article presents a consistency control algorithm for the autonomous underwater vehicle (AUV) group combined with the leader-follower approach under communication delay. First, the six-degree-of-freedom (DoF) model of AUV is represented, and the graph theory is used to describe the communication topology of the AUV group. Especially, a hybrid communication topology is introduced to adapt to large formation control.