Development and Application of Flue Gas Desulfurized Gypsum and Blast-Furnace-Slag-Based Grouting Material for Cracked Silty Mudstone.

The grouting technique is an efficient method for enhancing the stability of cracked slopes through the use of grouting materials. Conventional cement-based grouting materials are costly, energy-intensive, and environmentally damaging. Additionally, cement-hardening slurry is prone to cracks between the slurry and the rock.

How state mindfulness affects mobile phones usage while walking: A daily diary study in China.

Introduction: Pedestrians are a particularly vulnerable group of road users. Mobile phone usage while walking (MPUWW) is a significant contributor to pedestrians' involvement in road crashes and associated injuries. The current study aims to explore the effect of state mindfulness on daily MPUWW via phone dependence (at the within-person level), and the moderating role of risk perception (at the between-person level) in the phone dependence-MPUWW relationship.

Manipulating electron redistribution between iridium and CoMoC bridging with a carbon layer leads to a significantly enhanced overall water splitting performance at industrial-level current density.

Nowadays, alkaline water electrocatalysis is regarded as an economical and highly effective approach for large-scale hydrogen production. Highly active electrocatalysts functioning under large current density are urgently required for practical industrial applications. In this work, we present a meticulously designed methodology to anchor Ir nanoparticles on CoMoC nanofibers (CoMoC-Ir NFs) bridging with nitrogen-doped carbon as efficient bifunctional electrocatalysts with both excellent hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) activity and stability in alkaline media.

Lymph node targeting strategy using a hydrogel sustained-release system to load effector memory T cells improves the anti-tumor efficacy of anti-PD-1.

Communication between tumors and lymph nodes carries substantial significance for antitumor immunotherapy. Remodeling the immune microenvironment of tumor-draining lymph nodes (TdLN) plays a key role in enhancing the anti-tumor ability of immunotherapy. In this study, we constructed a biomimetic artificial lymph node structure composed of F127 hydrogel loading effector memory T (T) cells and PD-1 inhibitors (aPD-1).

Biomimetic MDSCs membrane coated black phosphorus nanosheets system for photothermal therapy/photodynamic therapy synergized chemotherapy of cancer.

Photothermal therapy is favored by cancer researchers due to its advantages such as controllable initiation, direct killing and immune promotion. However, the low enrichment efficiency of photosensitizer in tumor site and the limited effect of single use limits the further development of photothermal therapy. Herein, a photo-responsive multifunctional nanosystem was designed for cancer therapy, in which myeloid-derived suppressor cell (MDSC) membrane vesicle encapsulated decitabine-loaded black phosphorous (BP) nanosheets (BP@ Decitabine @MDSCs, named BDM).

Manganese drives ferroptosis of cancer cells via YAP/TAZ phase separation activated ACSL4 in OSCC.

Objective: Ferroptosis has been defined as a novel form of regulated cell death characterized by iron-dependent lipid peroxidation. Manganese has been used to induce ferroptosis in cancer cells recently. This study aims to investigate whether manganese can induce ferroptosis in oral squamous cell carcinoma (OSCC) and the underlying biological mechanisms.

3D-printed bioink loading with stem cells and cellular vesicles for periodontitis-derived bone defect repair.

The suitable microenvironment of bone regeneration is critically important for periodontitis-derived bone defect repair. Three major challenges in achieving a robust osteogenic reaction are the exist of oral inflammation, pathogenic bacteria invasion and unaffluent seed cells. Herein, a customizable and multifunctional 3D-printing module was designed with glycidyl methacrylate (GMA) modified epsilon-poly-L-lysine (EPLGMA) loading periodontal ligament stem cells (PDLSCs) and myeloid-derived suppressive cells membrane vesicles (MDSCs-MV) bioink (EPLGMA/PDLSCs/MDSCs-MVs, abbreviated as EPM) for periodontitis-derived bone defect repair.

Microwave-responsive gadolinium metal-organic frameworks nanosystem for MRI-guided cancer thermotherapy and synergistic immunotherapy.

The clinical application of cancer immunotherapy is unsatisfied due to low response rates and systemic immune-related adverse events. Microwave hyperthermia can be used as a synergistic immunotherapy to amplify the antitumor effect. Herein, we designed a Gd-based metal-organic framework (Gd-MOF) nanosystem for MRI-guided thermotherapy and synergistic immunotherapy, which featured high performance in drug loading and tumor tissue penetration.

Realizing a high OER activity in new single-atom catalysts formed by introducing TMN ( = 3 and 4) units into carbon nanotubes using high-throughput calculations.

Exploring highly efficient electrocatalysts for the oxygen evolution reaction (OER) is of great significance for hydrogen production through water splitting. By means of high-throughput density functional theory (DFT) calculations, we investigated the OER catalytic activity of a series of one-dimensional carbon nanotube (CNT)-based systems containing TMN or TMN functional units. Through the screening of 3d/4d/5d transition metals (TMs) from Group IVB to Group VIII, eight newly obtained TMN@CNT ( = 3 and 4) systems were found to exhibit excellent OER activity, with very low overpotentials in the range 0.

Rationally Construction of Mn-Doped RuO Nanofibers for High-Activity and Stable Alkaline Ampere-Level Current Density Overall Water Splitting.

Nowadays, highly active and stable alkaline bifunctional electrocatalysts toward water electrolysis that can work at high current density (≥1000 mA cm) are urgently needed. Herein, Mn-doped RuO (MnRuO) nanofibers (NFs) are constructed to achieve this object, presenting wonderful hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) performances with the overpotentials of only 269 and 461 mV at 1 A cm in 1 m KOH solution, and remarkably stability under industrial demand with 1 A cm, significantly better than the benchmark Pt/C and commercial RuO electrocatalysts, respectively. More importantly, the assembled MnRuO NFs||MnRuO NFs electrolyzer toward overall water splitting reaches the current density of 10 mA cm with a cell voltage of 1.

The role of oral microbiota in cancer.

Cancer remains a significant global challenge, with an estimated 47% increase in cancer patients from 2020 to 2040. Increasing research has identified microorganism as a risk factor for cancer development. The oral cavity, second only to the colon, harbors more than 700 bacterial species and serves as a crucial microbial habitat.

Porphyromonas gingivalis suppresses oral squamous cell carcinoma progression by inhibiting MUC1 expression and remodeling the tumor microenvironment.

Bacteria are the causative agents of various infectious diseases; however, the anti-tumor effect of some bacterial species has attracted the attention of many scientists. The human oral cavity is inhabited by abundant and diverse bacterial communities and some of these bacterial communities could play a role in tumor suppression. Therefore, it is crucial to find oral bacterial species that show anti-tumor activity on oral cancers.

Inhalation delivery of dexamethasone with iSEND nanoparticles attenuates the COVID-19 cytokine storm in mice and nonhuman primates.

Dexamethasone (DEX) is the first drug to show life-saving efficacy in patients with severe coronavirus disease 2019 (COVID-19), while DEX is associated with serious adverse effects. Here, we report an inhaled, Self-immunoregulatory, Extracellular Nanovesicle-based Delivery (iSEND) system by engineering neutrophil nanovesicles with cholesterols to deliver DEX for enhanced treatment of COVID-19. Relying on surface chemokine and cytokine receptors, the iSEND showed improved targeting to macrophages and neutralized broad-spectrum cytokines.

Theoretical Investigation of HER and OER Electrocatalysts Based on the 2D R-graphyne Completely Composed of Anti-Aromatic Carbon Rings.

Based on the DFT calculations, two-dimensional (2D) R-graphyne has been demonstrated to have high stability and good conductivity, which can be conducive to the relevant electrocatalytic activity of the material. Different from the poor graphene, R-graphyne, which is completely composed of anti-aromatic structural units, can exhibit certain HER catalytic activity. In addition, doping the TM atoms in Group VIIIB can be considered an effective strategy to enhance the HER catalytic activity of R-graphyne.

Innovative Strategies for Hair Regrowth and Skin Visualization.

Today, about 50% of men and 15-30% of women are estimated to face hair-related problems, which create a significant psychological burden. Conventional treatments, including drug therapy and transplantation, remain the main strategies for the clinical management of these problems. However, these treatments are hindered by challenges such as drug-induced adverse effects and poor drug penetration due to the skin's barrier.

Through the Self-Optimization process to achieve high OER activity of SAC catalysts within the framework of TMO@G and TMO@G: A High-Throughput theoretical study.

High-throughput DFT calculations are performed to explore the oxygen evolution reaction (OER) catalytic activity of a series of 2D graphene-based systems with TMO or TMO functional units. By screening the 3d/4d/5d transition metal (TM) atoms, a total of twelve TMO@G or TMO@G systems had extremely low overpotential of 0.33 ∼ 0.

PFC@O Targets HIF-1α to Reverse the Immunosuppressive TME in OSCC.

As a typical hallmark of solid tumors, hypoxia affects the effects of tumor radiotherapy, chemotherapy, and photodynamic therapy. Therefore, targeting the hypoxic tumor microenvironment (TME) is a promising treatment strategy for cancer therapy. Here, we prepared an Albumin Human Serum (HSA)-coated perfluorocarbon (PFC) carrying oxygen (PFC@O) to minimize OSCC hypoxia.

Advanced materials and technologies for oral diseases.

Oral disease, as a class of diseases with very high morbidity, brings great physical and mental damage to people worldwide. The increasing burden and strain on individuals and society make oral diseases an urgent global health problem. Since the treatment of almost all oral diseases relies on materials, the rapid development of advanced materials and technologies has also promoted innovations in the treatment methods and strategies of oral diseases.

Embedding Group VIII Elements into a 2D Rigid pc-CN Monolayer to Achieve Single-Atom Catalysts with Excellent OER Activity: A DFT Theoretical Study.

Under DFT calculations, a systematic investigation is carried out to explore the structures and oxygen evolution reaction (OER) catalytic activities of a series of 2D single-atom catalyst (SAC) systems, which are constructed by doping the transition metal (TM) atoms in group VIII into the cavities of rigid phthalocyanine carbide (pc-CN). We can find that when Co, Rh, Ir and Ru atoms are doped in the small or large cavities of a pc-CN monolayer, they can be used as high-activity centers of OER. All these four new TM@CN nanostructures can exhibit very low overpotential values in the range of 0.

"Swiss Army Knife" black phosphorus-based nanodelivery platform for synergistic antiparkinsonian therapy via remodeling the brain microenvironment.

The combination of excessive reactive oxygen species (ROS) levels, neuroinflammation, and pathogenic protein aggregation disrupt the homeostasis of brain microenvironment, creating conditions conducive to the progression of Parkinson's disease (PD). Restoring homeostasis by remodeling the brain microenvironment could reverse this complex pathological progression. However, treatment strategies that can induce this effect are currently unavailable.

STAT3 promotes differentiation of monocytes to MDSCs via CD39/CD73-adenosine signal pathway in oral squamous cell carcinoma.

Myeloid-derived suppressor cells (MDSCs) are one of the tumor-infiltrating immune cell population, which play a powerful role in inhibiting anti-tumor immune response. Our previous studies have shown that STAT3 blockade can decrease the number of MDSCs in tumor microenvironment. However, it is unclear for the molecular mechanism of down-regulation MDSCs with STAT3 inhibitor.

Brain-Targeted Biomimetic Nanodecoys with Neuroprotective Effects for Precise Therapy of Parkinson's Disease.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the gradual loss of dopaminergic neurons in the substantia nigra and the accumulation of α-synuclein aggregates called Lewy bodies. Here, nanodecoys were designed from a rabies virus polypeptide with a 29 amino acid (RVG29)-modified red blood cell membrane (RBCm) to encapsulate curcumin nanocrystals (Cur-NCs), which could effectively protect dopaminergic neurons. The RVG29-RBCm/Cur-NCs nanodecoys effectively escaped from reticuloendothelial system (RES) uptake, enabled prolonged blood circulation, and enhanced blood-brain barrier (BBB) crossing after systemic administration.