Publications by authors named "Guangshen Gao"
Triple-negative breast cancer (TNBC) is a heterogeneous subtype of breast cancer. Anti-PD-1/PD-L1 treatment for advanced TNBC is still limited to PD-L1-positive patients. Ataxia telangiectasia mutated (ATM) is a switch molecule for homologous recombination and repair.
View Article and Find Full Text PDFPurpose: Numerous studies had reported the diagnostic value of alkaline phosphatase (ALP) and its bone-specific isoforms (BAP) in the metastases of breast cancer (BC). The purpose of this meta-analysis was to summarize the diagnostic value of serum ALP and BAP in metastatic BC, especially focused on bone metastases.
Methods: We searched comprehensively in the PubMed, Cochrane Library, and EMBASE for studies to explore the diagnostic accuracy of serum ALP/BAP level for metastatic BC.
Invasive micropapillary carcinoma (IMPC) of the breast is a special histopathologic type of cancer with a high recurrence rate and the biological features of invasion and metastasis. Previous spatial transcriptome studies indicated extensive metabolic reprogramming in IMPC, which contributes to tumor cell heterogeneity. However, the impact of metabolome alterations on IMPC biological behavior is unclear.
View Article and Find Full Text PDFArticle Synopsis
- Triple-negative breast cancer (TNBC) is aggressive and lacks effective treatments, but PD-L1 inhibitors have been recently approved, prompting research on the involvement of ATM in regulating PD-L1 and patient prognosis.
- 86 TNBC samples were analyzed to uncover relationships between ATM, c-Src, STAT1, STAT3, PD-L1, and tumor-infiltrating lymphocytes (TILs), revealing that low ATM expression is linked to poor outcomes and a distinctive role of STAT3 in prognosis.
- The study suggests that TNBC patients with low ATM may benefit from anti-PD-L1 treatment and highlights the potential of combining ATM inhibitors with immune therapies, indicating that STAT3 influences tumor progression variably across different cancers.
Article Synopsis
- - Invasive micropapillary carcinoma (IMPC) is a unique type of breast cancer known for high rates of spreading through lymphatic systems, but its mechanisms for metastasis are not well understood, particularly from a transcriptomics perspective.
- - The research involved spatial transcriptomics sequencing on four IMPC samples, revealing significant genetic diversity and abnormal metabolic activity within different tumor regions, with notable findings around lipid metabolism and the SREBF1 gene.
- - High expression of the SREBF1 protein is linked to lymph node metastasis and poorer survival rates in IMPC patients, highlighting its potential as a crucial biomarker for diagnosis and treatment strategies.