Publications by authors named "Guangrui Xiong"
Objective: To explore the medical significance of methylated septin9 (mSEPT9) in monitoring recurrence and prognostic assessment in individuals with surgically treated colorectal cancer (CRC).
Methods: To investigate the role of Septin9 in colorectal cancer, we utilized the TIMER2.0 database to analyze its differential expression between tumor tissues and adjacent normal tissues.
Article Synopsis
- The study investigated the relationship between peripheral blood inflammation indexes and the prognosis of metastatic colorectal cancer (CRC) in 324 patients, finding that high levels of these markers correlated with poorer outcomes.
- Key inflammatory markers like IL-10, NLR, and LWR were identified, with critical values established to categorize patients into low-risk and high-risk groups based on their scores.
- Results indicated that patients in the low-risk group had significantly better overall survival (OS) and progression-free survival (PFS) compared to those in the high-risk group, emphasizing the importance of these inflammation indexes in predicting distant metastasis in CRC.
Colorectal cancer (CRC) represents 10% of all cancer types, making it the third leading cause of cancer-related deaths globally. Metastasis is the primary factor causing mortality in CRC patients. Approximately 22% of CRC-related deaths have metastasis present at diagnosis, with approximately 70% of these cases recurring.
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