Intracranial meningeal hemangiopericytoma: Recurrences at the initial and distant intracranial sites and extraneural metastases to multiple organs.

Regardless of the controversial pathogenesis, intracranial meningeal hemangiopericytoma (M-HPC) is a rare, highly cellular and vascularized mesenchymal tumor that is characterized by a high tendency for recurrence and extraneural metastasis, despite radical excision and postoperative radiotherapy. M-HPC shares similar clinical manifestations and radiological findings with meningioma, which causes difficulty in differentiation of this entity from those prognostically favorable mimics prior to surgery. Treatment of M-HPC, particularly in metastatic settings, remains a challenge.

Magnetic resonance characteristics of adult-onset Lhermitte-Duclos disease: An indicator for active cancer surveillance?

Lhermitte-Duclos disease (LDD) is a rare, non-cancerous entity characterized by enlarged, abnormally developed cerebellar folia containing dysplastic cells. Symptomatic LDD is commonly observed in adults (adult-onset LDD, aLDD) as an isolated condition or associated with Cowden's disease (CD). The present study aimed to investigate the magnetic resonance imaging (MRI) characteristics and the underlying pathological findings in 7 cases of aLDD, with emphasis on the association with CD and the need for active cancer surveillance once the diagnosis of LDD is confirmed.

Preparation and characterization of narrow-dispersed magnetic colloidal nanoparticle cluster/silica microspheres with controlled sizes, high saturation magnetization and MRI enhancement effect.

A comprehensive method combining polymerization-induced colloid aggregation, silica coating, and high-temperature calcination is developed for the preparation of micro-sized magnetic colloidal nanoparticle cluster/silica (CNC/silica) microspheres. The silica shell stabilizes the inner micro-sized γ-FeO nanoparticle clusters without phase transformation during high-temperature calcination instead of acting as anti-sintering agents. Their morphologies and inner structures are observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM).

Liver X receptor activation attenuates plaque formation and improves vasomotor function of the aortic artery in atherosclerotic ApoE(-/-) mice.

Aim: The severity of atherosclerosis is primarily determined by overall lipid metabolism and the degree of inflammation present within the vessel wall. We evaluated the effects of T-0901317, a liver X receptor agonist, on the atherosclerosis process, and especially on the endothelial function in ApoE(-/-) mice.

Methods And Results: ApoE(-/-) mice were treated with LXR agonist T-0901317 (1 μmol/L) for 6 weeks.

MRl of prostate cancer antigen expression for diagnosis and immunotherapy.

Background: Tumor antigen (TA)-targeted monoclonal antibody (mAb) immunotherapy can be effective for the treatment of a broad range of cancer etiologies; however, these approaches have demonstrated variable clinical efficacy for the treatment of patients with prostate cancer (PCa). An obstacle currently impeding translational progress has been the inability to quantify the mAb dose that reaches the tumor site and binds to the targeted TAs. The coupling of mAb to nanoparticle-based magnetic resonance imaging (MRI) probes should permit in vivo measurement of patient-specific biodistributions; these measurements could facilitate future development of novel dosimetry paradigms wherein mAb dose is titrated to optimize outcomes for individual patients.

MRI of prostate stem cell antigen expression in prostate tumors.

Background: The prostate stem cell antigen (PSCA) is broadly overexpressed on the surface of prostate cancer cells.

Materials & Methods: Anti-human PSCA monoclonal antibody (mAb 7F5) was bound to Fe(3)O(4)/Au (GoldMag) nanoparticles to serve as a PSCA-specific molecular MRI probe (mAb 7F5@GoldMag) for in vivo detection of prostate cancer cells. First, the efficacy of the antibody immobilization for the binding was assessed.

Normalized upper cervical spinal cord atrophy in multiple sclerosis.

Background And Purpose: To find an optimal normalizing factor for upper cervical spinal cord area (UCCA) and to establish whether, in a cross-sectional study, the normalized UCCA correlates better with the neurological disability than the absolute measurement in multiple sclerosis patients.

Methods: UCCA and three potential normalizing factors were estimated from magnetic resonance imaging data in 51 control subjects. Their reliability was assessed and the linear relationships between UCCA and three potential correction factors were investigated.

MRI and hybrid PET/CT for monitoring tumour metastasis in a metastatic breast cancer model in rabbit.

Objective: To study tumour growth and metastasis in a rabbit metastatic breast cancer (MBC) model and find the most sensitive screening modality in monitoring tumour metastasis.

Methods: The MBC model was established by injecting a VX2 tumour mass suspension into the mammary glands of 23 rabbits and was monitored by using physical examination, X-ray, MRI and hybrid PET/CT.

Results: Of all 23 rabbits, axillary lymph node metastasis was detected in 21 (91%) at day 33 after tumour inoculation, mediastinal node metastasis in five (22%) at day 42, abdominal node metastasis in two (9%) at day 48, lung metastasis in six (26%) at day 39, liver metastasis in three (13%) at day 48, and lumbar spine metastasis in one (4%) at day 51.