Publications by authors named "Guangnan Luo"

A compact helicon plasma source for the study of helicon plasma, especially for the study of blue core plasma, is designed and developed with permanent magnets (PMs). The structure of the PMs consists of two sets of ring array magnets with opposite magnetization. This structure can provide a higher magnetic field with fewer PMs, which is helpful for controlling the device's mass.

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Rationale: Mayer-Rokitansky-Küster-Hauser syndrome (MRKH syndrome) present with genital inguinal hernia was rare and probably under reported, on account of lack in typical gynecological symptom. It should be regarded with care.Here 3 cases diagnosed at our institution with detailed clinical information were present, and the literature was reviewed to paint a comprehensive profile of hernia uterine inguinale associated with MRKH syndrome.

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Purpose: Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) is characterized by congenital absence of the uterus, cervix, and the upper part of the vagina in females. Whole-gene deletion and loss-of-function variants in TBX6 have been identified in association with MRKHS. We aimed to expand the spectrum of TBX6 variants in MRKHS and explore the biological effect of the variant alleles.

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Deuterium permeation through vanadium membranes in a wide range of pressures and the temperature range ~250-550 °C was experimentally investigated. Measurements on the same material were carried out in three laboratories with different features for an extended characterization and for cross-check validation. A unified equation for deuterium permeability in pure vanadium (99%) was provided as Φ=1.

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Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is characterized by congenital malformations of Müllerian structures, including the uterus and upper two-thirds of the vagina in women. Until now, the etiology of this disease has remained unknown. We hypothesized that EMX2 (the human homologue of empty spiracles gene (2) might be a candidate gene for MRKH syndrome because it plays an important role in the development of the urogenital system.

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Objective: To introduce our experience of laparoscopic uterovaginal anastomosis and operative outcomes following this technique and update the clinical management of congenital cervicovaginal atresia.

Study Design: Between March 2015 and January 2019, twenty-three patients with congenital cervicovaginal atresia underwent laparoscopic uterovaginal anastomosis and Luohu procedure. Their clinical characteristics, surgical outcomes and follow-up data were retrospectively reviewed.

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Objective: To reveal the proportion of concomitant extragenital malformations in a large cohort of Chinese patients with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome.

Study Design: Retrospective study.

Setting: Tertiary teaching hospitals in China.

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Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) is associated with congenital absence of the uterus, cervix, and the upper part of the vagina; it is a sex-limited trait. Disrupted development of the Müllerian ducts (MD)/Wölffian ducts (WD) through multifactorial mechanisms has been proposed to underlie MRKHS. In this study, exome sequencing (ES) was performed on a Chinese discovery cohort (442 affected subjects and 941 female control subjects) and a replication MRKHS cohort (150 affected subjects of mixed ethnicity from North America, South America, and Europe).

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Article Synopsis
  • This study aimed to use whole genome sequencing (WGS) to identify mutations related to Mayer-Rokitansky-Küster-Hauser syndrome type 1 (MRKH syndrome type 1) in patients and their parents.
  • It involved nine unrelated patients (probands) with MRKH and led to the identification of numerous genetic variations, including 632 single nucleotide variants, 267 small insertions/deletions, and 39 structural variations over a two-year period.
  • The researchers discovered five notable mutations in key genes, suggesting that WGS can effectively enhance understanding of MRKH's genetic landscape and guide further investigations into the syndrome's pathogenesis.
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To investigate the artificial vaginal microecological features in patients who underwent laparoscopic peritoneal vaginoplasty. 54 cases of patients with artificial vagina after laparoscopic peritoneal vaginoplasty were included in this study. Microecosystem evaluation was performed.

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Objective: The aim of this study was to examine if the advanced tool of 3D MRI model provides more precise information on the anatomy of pelvic organs than MRI alone, and compare to clinical and operative finding of patients with vagina in Müllerian duct anomalies.

Study Design: One hundred and ten patients with clinically and operatively proven Müllerian duct anomalies were included. The consistency of diagnosis of Mullerian tract anomalies by MRI and 3D MRI compared to clinically and surgically proven anomalies defined according to ASRM classification.

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The diagnosis of the fuel retention and impurity deposition on the plasma facing components (PFCs) is very important for monitoring plasma-wall interactions and improving the performance of long-pulse operation for tokamak devices. In this study, a remote in situ laser-induced breakdown spectroscopic (RIS-LIBS) system has been developed to be an effective and routine method for the diagnosis of the composition of the PFCs on Experimental Advanced Superconducting Tokamak (EAST). The RIS-LIBS system can be operated between EAST discharges via a remote network control system.

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Fiber Bragg Gratings (FBGs) have been widely used in the sensor field to monitor temperature and strain. However, the weak mechanical property of optical fibers and insufficient heat-resistant property of general optic-fiber sensors have prevented it from being widely used, such as in some extreme engineering situations. In this work, a bare FBG sensor system had been introduced to measure thermal strain of an Experimental Advanced Superconducting Tokamak tungsten divertor component under baking condition.

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Plasma Facing Components (PFCs) in a magnetically confined fusion plasma device will be exposed to high heat load and particle fluxes, and it would cause PFCs' surface morphology to change due to material erosion and redeposition from plasma wall interactions. The state of PFCs' surface condition will seriously affect the performance of long-pulse or steady state plasma discharge in a tokamak; it will even constitute an enormous threat to the operation and the safety of fusion plasma devices. The PFCs' surface morphology evolution measurement could provide important information about PFCs' real-time status or damage situation and it would help to a better understanding of the plasma wall interaction process and mechanism.

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To facilitate long-pulse high power operation, an ITER-like actively cooled tungsten (W) divertor was installed in Experimental Advanced Superconducting Tokamak (EAST) to replace the original upper graphite divertor in 2014. A dedicated multichannel visible spectroscopic diagnostic system has been accordingly developed for the characterization of the plasma and impurities in the W divertor. An array of 22 lines-of-sight (LOSs) provides a profile measurement of the light emitted from the plasma along upper outer divertor, and the other 17 vertical LOSs view the upper inner divertor, achieving a 13 mm poloidal resolution in both regions.

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Dense W and W-Zr composites reinforced with Sc2O3 particles were produced through powder metallurgy and subsequent spark plasma sintering (SPS) at 1700 °C and 58 MPa. Results showed that the W-1vol.%Zr/2vol.

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Article Synopsis
  • The study aimed to investigate the clinical and phenotypic characteristics of Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome in a large patient group.
  • A total of 594 patients were examined using methods like ultrasound, MRI, and hormonal profiling, revealing that 7.2% had associated malformations, with renal issues being the most common.
  • The findings indicated a predominance of the normal karyotype (46,XX) in patients, but the lower rates of associated malformations compared to existing literature suggest potential variations based on geography or referral practices.
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Objective: To evaluate the outcomes of laparoscope-assisted peritoneal vaginoplasty for the treatment of congenital vaginal atresia.

Methods: A retrospective study enrolled patients diagnosed with congenital vaginal atresia who were treated with one of two different laparoscope-assisted peritoneal vaginoplasty techniques (named Luohu-one and Luohu-two) between October 31, 2001 and December 31, 2014. Operative time, intraoperative bleeding volume, surgical difficulty, complications, and post-procedure sexual satisfaction were reported.

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Background: Surgical vaginoplasty is the standard treatment for women suffering from Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome. This study compares the advantages and disadvantages of Luohu I technique or its modification, Luohu II technique.

Methods: Women with MRKH syndrome undergoing laparoscopic peritoneal vaginoplasty using either the Luohu I (N = 145) or Luohu II (N = 155) technique were recruited.

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A wet-chemical method combined with spark plasma sintering was used to prepare a W-Y2O3 alloy. High-temperature tensile tests and nano-indentation microhardness tests were used to characterize the mechanical properties of the alloy. After He-ion irradiation, fuzz and He bubbles were observed on the irradiated surface.

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Purpose: To investigate a better approach for androgen insensitivity syndrome (AIS) treatment using laparoscopic peritoneal or ileal vaginoplasty.

Method: Improved laparoscopic peritoneal vaginoplasty and gasless laparoscopic ileal vaginoplasty were, respectively, applied to AIS patients in vaginal reconstruction. The operation condition and surgical results were summarized and follow-up was performed from the 5th week after operation, then once a month.

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Objective: To investigate the technique and therapeutic effect of laparoscopy-insisted vaginoplasty with peritoneum in patients with androgen insensitivity syndrome.

Methods: From May. in the Fifth People' s Hospital of Shenzhen.

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Objective: To investigate the feasibility of complicate myomectomy.

Methods: Six-seven patients with complicated uterine myomas undergoing laparoscopic myomectomy were retrospectively analyzed. The myomectomy was done using ureteral infravision imaging system or/and with self-made myoma segregate-stick.

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