Detection of Debonding Defects in Concrete-Filled Steel Tubes Using Fluctuation Analysis Method.

This study presents a comprehensive method for detecting debonding defects in concrete-filled steel tube (CFST) structures using wave propagation analysis with externally attached piezoelectric ceramic sensors. Experimental tests and numerical simulations were conducted to evaluate the sensitivity and accuracy of two measurement techniques-the flat and oblique measurement methods-in detecting debonding defects of varying lengths and heights. The results demonstrate that the flat measurement method excels in detecting debonding height, while the oblique method is more effective for detecting debonding length.

The CTSC-RAB38 Fusion Transcript Is Associated With the Risk of Hemorrhage in Brain Arteriovenous Malformations.

Brain arteriovenous malformations (bAVMs) are congenital anomalies of blood vessels that cause intracranial hemorrhage in children and young adults. Chromosomal rearrangements and fusion genes play an important role in tumor pathogenesis, though the role of fusion genes in bAVM pathophysiological processes is unclear. The aim of this study was to identify fusion transcripts in bAVMs and analyze their effects.

Transthyretin Upregulates Long Non-Coding RNA MEG3 by Affecting PABPC1 in Diabetic Retinopathy.

The aim of the study was to demonstrate how transthyretin (TTR) could affect long non-coding RNA (lncRNA) of maternally expressed gene 3 (MEG3) and play important roles in diabetic retinopathy (DR). A DR model in C57BL/6 mice was established after intraperitoneal injection of streptozotocin (STZ). After intravitreal injection with TTR pAAV vector, MEG3 short hairpin RNA (shRNA), scrambled shRNA, or MEG3, retinal imaging, retinal trypsin digestion, and fundus vascular permeability tests were performed.

Transcriptome analysis identified a novel 3-LncRNA regulatory network of transthyretin attenuating glucose induced hRECs dysfunction in diabetic retinopathy.

Background: Diabetic retinopathy (DR) is the leading cause of blindness in the working age population. Transthyretin (TTR) showed a significantly decreased concentration in DR patients and exerted a visual protective effect by repressing neovascularization. This work intended to identify long non coding RNAs (lncRNAs) and explore their potential mechanism underlying the protective role of TTR.

A novel transthyretin/STAT4/miR-223-3p/FBXW7 signaling pathway affects neovascularization in diabetic retinopathy.

MicroRNAs (miRNAs) are small RNAs without protein-coding functions that negatively regulate target genes and play important roles in physiological and pathological processes. The aim of this work was to reveal a novel miRNA/gene pathway in diabetic retinopathy (DR). A microarray was used to screen miRNAs in samples from nondiabetic controls and patients with DR, and miR-223-3p was screened as a potential candidate.

KCNQ1OT1 affects the progression of diabetic retinopathy by regulating miR-1470 and epidermal growth factor receptor.

Long noncoding RNAs have been reported to play important roles in the pathogenesis of diabetic retinopathy (DR), which has been considered as the most common disease leading to vision loss. However, it is still unclear whether KCNQ1 overlapping transcript 1 (KCNQ1OT1) could affect DR. In this study, regarding quantitative reverse transcription polymerase chain reaction assay, KCNQ1OT1 level was upregulated while microRNA-1470 (miR-1470) was decreased in DR patients and human retinal endothelial cells.

Preparation and characterization of copper-Brevibacterium cholesterol oxidase hybrid nanoflowers.

Brevibacterium cholesterol oxidase (COD)-Cu hybrid nanoflowers were prepared, optimized and characterized for structural and catalytic properties. Regarding scanning electron microscopy (SEM), Fourier transform-infrared spectroscopy (FTIR) and X-ray diffraction (XRD) assays, COD molecules were successfully encapsulated with Cu(PO)·3HO based hybrid nanoflowers. After immobilization in hybrid nanoflowers, the interaction between COD and flavo-cofactor (FAD) was enhanced; and regarding to differential scanning calorimetry (DSC) assay, the T value of immobilized COD was increased from 60.

Affinity adsorption of bovine hyaluronidase with ligands targeting to active site.

Four affinity ligands were designed from 6-chloromethyluracil and 2-aminobenzimidazole and simulated for the interaction with bovine hyaluronidase-1. Regarding sequence alignment, bovine hyaluronidase-1 precursor showed circa 83.6% similarity with human hyaluronidase-1.

Investigation of toxin gene diversity and antimicrobial resistance of strains.

The incidence of infection (CDI) has been previously reported in a number of studies. However, data collected from the Chinese population is limited. In the present study, the diversity of the toxin genes, and of 57 () isolates from a Chinese population were investigated by polymerase chain reaction (PCR) (38 AB, 14 AB and 5 AB).

[Application of 3D-CT angiography in the diagnosis and post-operative evaluation of intracranial aneurysms].

Objective: To assess the values of three-dimensional CT (3D-CT) angiography (3D-CTA) in the diagnosis and operative follow up of intracranial aneurysms after clip.

Methods: 3D-CTA and DSA were performed on 32 patients with clinical manifestations suggestive of harboring intracranial aneurysms. DSA and operation were regarded as gold standards.