Anti-inflammatory abietanes diterpenes and triterpenoids isolated from Clinopodium polycephalum.

Two previously undescribed diterpenes (1 and 2), as well as one curious triterpenoid were isolated from Clinopodium polycephalum, a medicinal plant distributed in southwestern and eastern China. Their structures were elucidated using MS analyses, UV spectrum, and extensive 2D-homo and heteronuclear NMR data interpretations. Among them, 1 had an unusual skeletal characteristic produced by a rare methyl migration pathway.

Chemical constituents and biological activities of H.Lév. & vaniot.

is a widely distributed and inexpensive plant resource, and study on its chemical compositions and biological activities will provide an important basis for its food applications and pharmaceutical developments. In this study, fourteen known guaiane-type sesquiterpenes (1-14), four known eudesmane-type sesquiterpenes (15-18), two known germacranolide-type sesquiterpenes (19, 20), and eight other types of terpenoids (20-28) were isolated from the leaves of by polyamide and ODS CC and HPLC. The structures of all compounds are determined by 1 D NMR (H-NMR、C-NMR) and literature comparison.

Guaianolide Sesquiterpenes With Significant Antiproliferative Activities From the Leaves of .

Four new guaiane-type sesquiterpenes, argyin H-K (1-4), and two known analogues (5 and 6) were isolated from the leaves of Lévl et Vant. The new compounds were characterized by the basic analysis of the spectroscopic data obtained (H NMR, C NMR, HMBC, and NOESY experiments), and their absolute configurations were determined by empirical approaches, combined with the exciton chirality method and electronic circular dichroism calculations. To further understand the antitumor effects of , the antiproliferative activities of these compounds against A549, MCF-7, and HepG2 cell lines were tested using CCK-8 assays.

Rare benzonaphthoxanthenones from Chinese folk herbal medicine Polytrichum commune and their anti-neuroinflammatory activities in vitro.

Two new (1-2) as well as five known (3-7) compounds were isolated from Polytrichum commune, a folk herbal medicine in China, and three of them (2, 4, 5) belong to benzonaphthoxanthenones that are rarely found in nature. Their structures were elucidated by the approach to 1D and 2D NMR spectra. The absolute configuration of 2 was assigned by comparing its experimental and calculated ECD data.