Synthesis of -Vinyl Cinnamaldehyde Nitrones through Atropisomeric Quinoxaline-Derived ,,-Ligand-Promoted Chan-Lam Reaction.

A type of quinoxaline-derived tridentate ,,-ligand was synthesized in good to excellent yields over three steps through iodination of 2-aryl indoles, sequential Kornblum-type oxidation with DMSO, and capture by 1,2-diaminobenzenes. The prepared atropisomeric ,,-ligand was successfully applied in the synthesis of -vinyl cinnamaldehyde nitrones as only -isomers in good yields through the Chan-Lam reaction. The method features an easily accessed tunable tridentate ,,-ligand, broad substrate scope, good functional group tolerance, and high -isomer for -vinyl nitrones.

Cinchonidine-Catalyzed Synthesis of Oxazabicyclo[4.2.1]nonanones from -Aryl--unsaturated Nitrones and 1-Ethynylnaphthalen-2-ols.

A variety of oxazabicyclo[4.2.1]nonanone derivatives were prepared in good yields through a cinchonidine-catalyzed cascade reaction of -aryl-α,β-unsaturated nitrones and 1-ethynylnaphthalen-2-ols.

Naturally occurring autoantibodies against Aβ oligomers exhibited more beneficial effects in the treatment of mouse model of Alzheimer's disease than intravenous immunoglobulin.

Alzheimer's disease (AD) is characterized by memory loss, intracellular neurofibrillary tangles, and extracellular plaque deposits composed of β-amyloid (Aβ). Previous reports showed that naturally occurring autoantibodies, such as intravenous immunoglobulin (IVIG), benefited patients with moderate-stage AD who carried an APOE-ε4 allele. However, the mechanism underlying the role of IVIG remains unclear.

N-terminal PEGylation of human serum albumin and investigation of its pharmacokinetics and pulmonary microvascular retention.

Human serum albumin (HSA) is used as an important plasma volume expander in clinical practice. In the present study, HSA was N-terminally PEGylated and a PEGylated HAS (PEG-HSA) carrying one chain of PEG (20 kDa) per HSA molecule was obtained. The purity, secondary structure and hydrodynamic radius of the modified protein were characterized using sodium dodecyl sulfate polyacrylamide gel electrophoresis, circular dichroism measurements, and dynamic light scattering, respectively.