CircANXA4 (hsa_circ_0055087) regulates the miR-1256/PRM1 axis to promote tumor progression in colorectal cancer.

Colorectal cancer (CRC) incidence ranks third among malignant cancers with a high propensity for distant metastasis. Despite continuous efforts to improve treatment, the prognosis especially in patients with advanced distant metastasis is low. The mechanism of development and progression of CRC is not fully understood.

MiR-485-3p/MiR-543/MiR-337-3p is Required for the Oncogenic Potential of the Hsa_circ_0007385-MEMO1 Axis in Colorectal Cancer.

Circular RNAs (circRNAs) play regulatory roles in the biological processes of multiple tumors, colorectal cancer (CRC) included. Our previous study probed the impact of circ_0007385 on CRC cell malignant behaviors, while the underlying mechanism remains obscure. In this work, the potential mechanism of hsa_circ_0007385 in CRC was probed.

Up-regulation of lncRNA NEAT1 in cerebral ischemic stroke promotes activation of astrocytes by modulation of miR-488-3p/RAC1.

We aim to research the molecular mechanism of lncRNA NEAT1 in the activation of astrocytes in a cerebral ischemia-reperfusion injury model. Mouse model of cerebral ischemia-reperfusion injury was constructed, and shNEAT1 was transfected. The infarct area, brain water content, and neurological deficiency were detected.

Oxygen vacancies enhance the lithium ion intercalation pseudocapacitive properties of orthorhombic niobium pentoxide.

While orthorhombic niobium pentoxide (T-NbO) is one of the most promising energy storage material with rapid lithium ion (Li) intercalation pseudocapacitive response, a key challenge remains the achievement of high-rate charge-transfer reaction when fabricated into thick electrodes. Herein, we report a facile method to create intrinsic defects in T-NbO through a hydrogen (H) reduction, which is effective to overcome the limitations of electrochemical utilization and rate capability. Due to the high number of active sites introduced, the specific capacity of hydrogenated (H-) NbO with oxygen vacancies reaches 649 C g at 0.