Persistently elevated glycolysis in kidney has been demonstrated to promote chronic kidney disease (CKD). However, the underlying mechanism remains largely unclear. Here, we observed that 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), a key glycolytic enzyme, was remarkably induced in kidney proximal tubular cells (PTCs) following ischemia-reperfusion injury (IRI) in mice, as well as in multiple etiologies of patients with CKD.
View Article and Find Full Text PDFDecreased plasma spermine levels are associated with kidney dysfunction. However, the role of spermine in kidney disease remains largely unknown. Herein, it is demonstrated that spermine oxidase (SMOX), a key enzyme governing polyamine metabolism, is predominantly induced in tubular epithelium of human and mouse fibrotic kidneys, alongside a reduction in renal spermine content in mice.
View Article and Find Full Text PDFThe electrocatalytic production of "green hydrogen", such as through the electrolysis of water or urea has been vigorously advocated to alleviate the energy crisis. However, their electrode reactions including oxygen evolution reaction (OER), urea oxidation reaction (UOR), and hydrogen evolution reaction (HER) all suffer from sluggish kinetics, which urgently need catalysts to accelerate the processes. Herein, we design and prepare an OER/UOR/HER trifunctional catalyst by transforming the homemade CoO nanorod into a two-dimensional (2D) ultrathin heterojunction nickel-iron-cobalt hybrid phosphides nanosheet (NiFeP/CoP) via a hydrothermal-phosphorization method.
View Article and Find Full Text PDFPurpose: The prognosis of patients receiving peritoneal dialysis (PD) is associated with inflammation. Systemic immune-inflammation index (SII) is one of inflammatory markers, and the role in predicting clinical outcomes in PD patients is unclear. We aimed to investigate the relationship between the SII and all-cause and cardiovascular-specific mortalities in patients undergoing PD.
View Article and Find Full Text PDFBaicalein (5,6,7-trihydroxyflavone) is a traditional Chinese medicine with multiple pharmacological and biological activities including anti-inflammatory and anti-fibrotic effects. However, whether baicalein has a therapeutic impact on peritoneal fibrosis has not been reported yet. In the present study, network pharmacology and molecular docking approaches were performed to evaluate the role and the potential mechanisms of baicalein in attenuating peritoneal dialysis-associated peritoneal fibrosis.
View Article and Find Full Text PDFThe exploring of economical, high-efficiency, and stable bifunctional catalysts for hydrogen evolution and oxygen evolution reactions (HER/OER) is highly imperative for the development of electrolytic water. Herein, a 3D cross-linked carbon nanotube supported oxygen vacancy (V )-rich N-NiMoO /Ni heterostructure bifunctional water splitting catalyst (N-NiMoO /Ni/CNTs) is synthesized by hydrothermal-H calcination method. Physical characterization confirms that V -rich N-NiMoO /Ni nanoparticles with an average size of ≈19 nm are secondary aggregated on CNTs that form a hierarchical porous structure.
View Article and Find Full Text PDFLong-term peritoneal dialysis (PD) is associated with the development of peritoneal fibrosis (PF). Understanding the changes of immune environments and peritoneal mesothelial cells (PMCs) may lead to the discovery of mechanisms of PF. Therefore, we used single-cell RNA sequencing to interrogate cell composition and transcriptome characteristics in dialysate of continuous ambulatory PD (CAPD) patients at different stages.
View Article and Find Full Text PDFIntroduction: Older people in community are susceptible to acute kidney injury (AKI) and hemodialysis is the most important supportive measure used in the management of severe AKI. This study aims to investigate the clinical characteristics, outcomes and risk factors for mortality in older patients with dialysis-receiving-community-acquired AKI (CA-AKI).
Methods: A total of 1953 CA-AKI patients aged 65 years old and above were recruited from 2013 to 2016.
Introduction: The clinicopathologic characteristics of Hepatitis B virus-associated glomerulonephritis (HBV-GN) patients with different serum HBsAg are not well known. This study aims to investigate the characteristics and treatments between HBV-GN patients with positive and negative serum HBsAg.
Methods: A retrospective review of patients with renal biopsies in Guangdong Provincial People's Hospital from 2005 to 2018 was performed.
The role of M2 macrophages in the pathogenesis and progression of primary membranous nephropathy (PMN) remains unknown. In this study, we aimed to investigate the relationship between M2 subsets and clinicopathological features of patients with PMN. A total of 55 patients with PMN confirmed by biopsy were recruited.
View Article and Find Full Text PDFThe transcription factor PU.1, an important member of the ETS family, plays a significant role in the differentiation of immune cells, which include macrophages, neutrophils, dendritic cells, T lymphoid cells, B lymphoid cells and so on. Immune cells are involved in the occurrence and development of diseases, including inflammatory diseases, neoplastic diseases and immune diseases.
View Article and Find Full Text PDFThe development of cost-effective and durable oxygen electrocatalysts remains highly critical but challenging for energy conversion and storage devices. Herein, a novel FeNi alloy nanoparticle core encapsulated in carbon shells supported on a N-enriched graphene-like carbon matrix (denoted as FeNi@C/NG) was constructed by facile pyrolyzing the mixture of metal salts, glucose, and dicyandiamide. The in situ pyrolysis of dicyandiamide in the presence of glucose plays a significant effect on the fabrication of the porous FeNi@C/NG with a high content of doped N and large specific surface area.
View Article and Find Full Text PDFFormaldehyde is the main cause of indoor pollution. In this research, we investigated the mechanism that the covalent organic framework (COF) identifies formaldehyde applying density functional theory (DFT) and time-dependent (TD) DFT approaches. On one hand, the calculation results of the geometric parameters, IR spectra, as well as H-NMR chemical shifts for protons that associated with the hydrogen bonding formation together with the electronic transition energies verified that the furcate hydrogen bonding formed between the COF and formaldehyde is enhanced in the excited S state and it is not beneficial to luminescence of the COF.
View Article and Find Full Text PDFThis article presents a recognition mechanism for nitro-explosives by the luminescent metal-organic framework 1 (LMOF-1) with the aid of density functional theory (DFT) and time-dependent density functional theory (TDDFT). The behavior of hydrogen bonding between the LMOF-1 and nitro-explosives in the S state is closely associated with the fluorescence properties of the LMOF-1. In our research, we calculated the geometric configuration, H NMR and IR spectra of the Complex 2 formed by LMOF-1 and nitrobenzene in the S and S states.
View Article and Find Full Text PDFExploring cost-effective, high-performance and durable non-precious metal catalysts is of great significance for the acceleration of sluggish oxygen reduction reaction (ORR). Here, we report an intriguing heteroatom-doped graphitized carbon encased Fe species composite by introducing N, S and B sequentially. The experimental approach was designed ingeniously for that the FeCl·6HO could catalyze thiourea to synthesize N, S co-doped carbon materials which would further react with HBO and NH (emerged at the heat-treatment process) to prepare N, S and B co-doped carbon materials (Fe-N/S/B-C).
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
August 2017
The influence of oxygen molecule on the luminescent properties of a cyclometalated Pt(II) complex Lxp1, was investigated using density functional theory (DFT) and time-dependent density functional theory (TDDFT) methods. Analysis of frontier molecular orbitals and electronic configuration indicated that the highest-occupied molecular orbital of the Lxp1 has a significant mixture of metal Pt (d) as well as 2-phenylpyridine and acetyl acetone(π). The lowest-unoccupied orbital of the Lxp1 primarily locates on π* of 2-phenylpyridineligands.
View Article and Find Full Text PDFPromoting the oxygen reduction reaction (ORR) catalytic activities of cost-effective catalysts is of great significance for the development of various energy conversion and storage systems. Herein, we describe the preparation of a highly active N- and S-co-doped ketjenblack (Kb) by facile pyrolysis of a mixture of thiourea and Kb in the presence of FeCl ⋅6 H O followed by an acid-leaching process. This novel synthetic approach was rationally designed with the consideration that thiourea could easily introduce both N and S heteroatoms into the carbon matrix by a heat-treatment method by releasing plentiful reactive N- and S-containing gases, which could simultaneously optimize the porous structure of the resultant catalyst.
View Article and Find Full Text PDFA ferrocene-based ionic liquid (Fe-IL) is used as a metal-containing feedstock with a nitrogen-enriched ionic liquid (N-IL) as a compatible nitrogen content modulator to prepare a novel type of non-precious-metal-nitrogen-carbon (M-N-C) catalysts, which feature ordered mesoporous structure consisting of uniform iron oxide nanoparticles embedded into N-enriched carbons. The catalyst Fe(10) @NOMC exhibits comparable catalytic activity but superior long-term stability to 20 wt % Pt/C for ORR with four-electron transfer pathway under alkaline conditions. Such outstanding catalytic performance is ascribed to the populated Fe (Fe3 O4 ) and N (N2) active sites with synergetic chemical coupling as well as the ordered mesoporous structure and high surface area endowed by both the versatile precursors and the synthetic strategy, which also open new avenues for the development of M-N-C catalytic materials.
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