Publications by authors named "Guangjun Xiao"
N4-acetylcytidine (ac4C) modification is a crucial RNA modification widely present in eukaryotic RNA. Previous studies have demonstrated that ac4C plays a pivotal role in viral infections. Despite numerous studies highlighting the strong correlation between ac4C modification and cancer progression, its detailed roles and molecular mechanisms in normal physiological processes and cancer progression remain incompletely understood.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the relationship between the Chinese visceral adiposity index (CVAI) and the production of neutralizing antibodies (NAb) after vaccination against SARS-CoV-2, highlighting the importance of understanding how visceral fat affects vaccine efficacy.
- - Health workers who were part of the study showed a median NAb titer of 12.94 AU/mL post-vaccination, with those in the CVAI dysfunction group having significantly lower NAb levels and higher inflammation markers compared to the reference group.
- - The findings suggest that high CVAI could hinder NAb production through immune dysfunction and chronic inflammation, emphasizing the need for targeted vaccination strategies for individuals with high visceral adiposity to enhance overall vaccination effectiveness against COVID-
Integrin alpha L (ITGAL) seemed to play a critical role in carcinogenesis and immune regulation. Nevertheless, the effects of ITGAL on non-small cell lung cancer (NSCLC) remain elusive. The present paper intended to determine the effects of ITGAL in NSCLC via the integration of bioinformatic analyses.
View Article and Find Full Text PDFAir particulate matter (PM) is an essential risk factor for lipid metabolism disorders. However, the underlying mechanism remains unclear. In this cross-sectional study, 216 healthcare workers were recruited to estimate the associations among the daily exposure dose (DED) of air PM, innate immune cells, and plasma lipid levels.
View Article and Find Full Text PDFArticle Synopsis
- Integrating fluorescent chromophores into aromatic frameworks can prevent quenching effects and enhance fluorescence properties.
- The study focuses on creating -tetrazine-bridged aromatic frameworks, using -tetrazine as a foundational component in a tetrahedral structure.
- The resulting thin films showed impressive reversible photoswitching fluorescence under UV and visible light, along with strong fluorescence stability and contrast, due to light-induced transformations of -tetrazine between its neutral and radical states.
The associations between air pollutant exposure and neutralizing antibody titers of an inactivated SARS-CoV-2 vaccine.
Environ Sci Pollut Res Int
February 2022
Air pollution is a critical risk factor for the prevalence of COVID-19. However, few studies have focused on whether air pollution affects the efficacy of the SARS-CoV-2 vaccine. To better guide the knowledge surrounding this vaccination, we conducted a cross-section study to identify the relationships between air pollutant exposure and plasma neutralizing antibody (NAb) titers of an inactivated SARS-CoV-2 vaccine (Vero cell, CoronaVac, SINOVΛC, China).
View Article and Find Full Text PDF