Publications by authors named "Guangjun Li"

β-Branched aromatic α-amino acids are valuable building blocks in natural products and pharmaceutically active compounds. However, their chemical or enzymatic synthesis is challenging due to the presence of two stereocenters. We design phenylalanine ammonia lyases (PAL) variants for the direct asymmetric synthesis of β-branched aromatic α-amino acids.

View Article and Find Full Text PDF

By highly efficient ligand-exchange strategy, atomically precise AuPd(PPh) (PPh=triphenylphosphine) cluster can be transformed into a AuPd(DPPF) (DPPF=1,1'-bis(diphenylphosphino)ferrocene) cluster that can maintain the atomic-packing structure but overcome the lability of AuPd(PPh) . Catalytic evaluation for the CO hydrogenation coupled with o-phenylenediamine demonstrates that the AuPd(DPPF) catalyst can remarkably enhance both activity and stability compared to the AuPd(PPh) catalyst. More notably, the direct construction of a two-dimensional metal-organic framework (2D MOF) can be elaborately accomplished in the formylation process of o-phenylenediamine, CO and H with zinc nitrate enabled by the AuPd(DPPF) catalyst.

View Article and Find Full Text PDF

Hepatocellular carcinoma (HCC) is one of the malignant tumors with high morbidity and mortality. Long non-coding RNAs (lncRNAs) are frequently dysregulated in human cancers and play an important role in the initiation and progression of HCC. Here, we investigated the expression of a new reported lncRNA495810 in our previous study by analyzing the publicly available datasets and using RT-qPCR assay.

View Article and Find Full Text PDF
Article Synopsis
  • A deep learning model, 3D-MResNet, was evaluated for its ability to predict and classify patient-specific quality assurance results for volumetric modulated arc therapy, aimed at enhancing efficiency in PSQA workflows.
  • The model analyzed 761 VMAT plans and demonstrated mean absolute errors of 1.63% and 2.38% for different gamma criteria, achieving high classification rates and low error rates for predicted versus measured gamma passing rates.
  • The results suggest that integrating the 3D-MResNet model can significantly improve the accuracy and efficiency of the PSQA process in VMAT, potentially reducing the need for extensive onsite measurements.
View Article and Find Full Text PDF

Malnutrition, which is often underestimated in patients with hepatocellular carcinoma (HCC), has a proven adverse effect on survival rates. The purpose of this study was to verify the effectiveness of the cholesterol-modified prognostic nutritional index (CPNI) in determining the nutritional status and predicting overall survival (OS) and recurrence-free survival (RFS) in patients with HCC by comparing it with several other nutritional indicators. This retrospective single-center study enrolled 1450 consecutive HCC patients who underwent curative liver resection from January 2015 to November 2019.

View Article and Find Full Text PDF

Background: Cardiac stereotactic body radiotherapy (CSBRT) with photons efficaciously and safely treats cardiovascular arrhythmias. Proton therapy, with its unique physical and radiobiological properties, can offer advantages over traditional photon-based therapies in certain clinical scenarios, particularly pediatric tumors and those in anatomically challenging areas. However, dose uncertainties induced by cardiorespiratory motion are unknown.

View Article and Find Full Text PDF
Article Synopsis
  • Cardiac stereotactic body radiotherapy (CSBRT) is a cutting-edge treatment for arrhythmias that delivers high-dose radiotherapy precisely to affected areas, aiming to minimize damage to surrounding healthy tissues.
  • However, this technique faces challenges due to the movement of the heart and lungs, which can complicate accurate dose delivery and lead to uncertainties in treatment effectiveness.
  • A study evaluating the effects of cardiac and respiratory motion on radiation delivery in 12 arrhythmia patients found that cardiac movement has less displacement than respiratory motion but contributes to variability in heart structure volumes, highlighting the need for improved techniques in CSBRT planning and execution.
View Article and Find Full Text PDF

Radiotherapy is a pivotal means of cancer treatment, but it often leads to radiation dermatitis, a skin injury caused by radiation-induced excess reactive oxygen species (ROS). Scavenging free radicals in the course of radiation therapy will be an effective means to prevent radiation dermatitis. This study demonstrates a novel double network hydrogel doped with MoS nanosheets for the prevention of radiation-induced dermatitis.

View Article and Find Full Text PDF
Article Synopsis
  • * Using methods like the HFACS and Bayesian networks, the study analyzed 81 incidents to identify key factors contributing to unsafe practices, primarily during the treatment planning phase.
  • * The results reveal that operator conditions, personnel, and environmental factors play significant roles in these incidents, emphasizing the need for interventions targeting organizational climate and processes for improved safety in radiation therapy.
View Article and Find Full Text PDF

Radiation therapy relies on quality assurance (QA) to verify dose delivery accuracy. However, current QA methods suffer from operation lag as well as inaccurate performance. Hence, to address these shortcomings, this paper proposes a QA neural network model based on branch architecture, which is based on the analysis of the category features of the QA complexity metrics.

View Article and Find Full Text PDF

Aromatic polyketides are renowned for their wide-ranging pharmaceutical activities. Their structural diversity is mainly produced via modification of limited types of basic frameworks. In this study, we characterized the biosynthesis of a unique basic aromatic framework, phenyldimethylanthrone (PDA) found in (+)/(-)-anthrabenzoxocinones (ABXs) and fasamycin (FAS).

View Article and Find Full Text PDF

Colletotrichum higginsianum causes anthracnose disease in brassicas. The availability of the C. higginsianum genome has paved the way for the genome-wide exploration of genes associated with virulence/pathogenicity.

View Article and Find Full Text PDF

The application of semiconductor metal oxides in chemiresistive methane gas sensors has seen significant progress in recent years, driven by their promising sensitivity, miniaturization potential, and cost-effectiveness. This paper presents a comprehensive review of recent developments and future perspectives in this field. The main findings highlight the advancements in material science, sensor fabrication techniques, and integration methods that have led to enhanced methane-sensing capabilities.

View Article and Find Full Text PDF

Purpose: Image segmentation can be time-consuming and lacks consistency between different oncologists, which is essential in conformal radiotherapy techniques. We aimed to evaluate automatic delineation results generated by convolutional neural networks (CNNs) from geometry and dosimetry perspectives and explore the reliability of these segmentation tools in rectal cancer.

Methods: Forty-seven rectal cancer cases treated from February 2018 to April 2019 were randomly collected retrospectively in our cancer center.

View Article and Find Full Text PDF

Respiratory motion tracking techniques can provide optimal treatment accuracy for thoracoabdominal radiotherapy and robotic surgery. However, conventional imaging-based respiratory motion tracking techniques are time-lagged owing to the system latency of medical linear accelerators and surgical robots. This study aims to investigate the precursor time of respiratory-related neural signals and analyze the potential of neural signals-based respiratory motion tracking.

View Article and Find Full Text PDF

Quality assurance (QA) is important for ensuring precision in radiation therapy. The complexity and resource-intensive nature of QA has increased with the continual evolution of equipment and techniques. An effective approach is to improve the process control technology and resource optimization.

View Article and Find Full Text PDF

Purpose: To assess the effect of sampling variability on the performance of individual charts (I-charts) for PSQA and provide a robust and reliable method for unknown PSQA processes.

Materials And Methods: A total of 1327 pretreatment PSQAs were analyzed. Different datasets with samples in the range of 20-1000 were used to estimate the lower control limit (LCL).

View Article and Find Full Text PDF

Heterodimeric tryptophan-containing diketopiperazines (HTDKPs) are an important class of bioactive secondary metabolites. Biosynthesis offers a practical opportunity to access their bioactive structural diversity, however, it is restricted by the limited substrate scopes of the HTDKPs-forming P450 dimerases. Herein, by genome mining and investigation of the sequence-product relationships, we unveiled three important residues (F387, F388 and E73) in these P450s that are pivotal for selecting different diketopiperazine (DKP) substrates in the upper binding pocket.

View Article and Find Full Text PDF

To determine the path of disease in different types of networks, a new method based on compressive sensing is proposed for identifying the disease propagation paths in two-layer networks. If a limited amount of data from network nodes is collected, according to the principle of compressive sensing, it is feasible to accurately identify the path of disease propagation in a multilayer network. Experimental results show that the method can be applied to various networks, such as scale-free networks, small-world networks, and random networks.

View Article and Find Full Text PDF

It has become possible to establish a connection between homogeneous and heterogeneous catalysis with atomically precise metal clusters. Due to their defined coordination geometry, in this work, atomically precise Pd Au (PPh ) clusters are exploited to identify the crucial factor that can impact the catalytic efficiency for the Suzuki-Miyaura cross-coupling process and further gain valuable insight into the exclusive cooperative effect of the central Pd atom and the peripheral Au atoms of the Pd Au (PPh ) cluster on controlling the cross-coupling reaction. Specifically, a heterogeneous catalyst, namely Pd Au @Resin, is designed by exchanging positively charged Pd Au (PPh ) clusters into the porous resin, thereby not only facilitating catalyst recyclability when performed in a batch reactor, but also realizing time-on-stream performance for the Suzuki-Miyaura cross-coupling reaction carried out in a fixed-bed reactor.

View Article and Find Full Text PDF

Multiple viral infections in insect vectors with synergistic effects are common in nature, but the underlying mechanism remains elusive. Here, we find that rice gall dwarf reovirus (RGDV) facilitates the transmission of rice stripe mosaic rhabdovirus (RSMV) by co-infected leafhopper vectors. RSMV nucleoprotein (N) alone activates complete anti-viral autophagy, while RGDV nonstructural protein Pns11 alone induces pro-viral incomplete autophagy.

View Article and Find Full Text PDF

Background: Internal tumor motion is commonly predicted using external respiratory signals. However, the internal/external correlation is complex and patient-specific. The purpose of this study was to develop various models based on the radiomic features of computed tomography (CT) images to predict the accuracy of tumor motion tracking using external surrogates and to find accurate and reliable tracking algorithms.

View Article and Find Full Text PDF

Background: Accurately predicting the prognosis of patients with high-grade glioma (HGG) is potentially important for treatment. However, the predictive value of images of various magnetic resonance imaging (MRI) sequences for prognosis at different time points is unknown. We established predictive machine learning models of HGG disease progression and recurrence using MRI radiomics and explored the factors influencing prediction accuracy.

View Article and Find Full Text PDF

Adaptive radiotherapy can modify the treatment plan online based on the clinical target volume (CTV) and organ at risk (OAR) contours on the cone-beam CT (CBCT) before treatment, improving the accuracy of radiotherapy. However, manual delineation of CTV and OAR on CBCT is time-consuming. In this study, a deep neural network-based method based on U-Net was purposed.

View Article and Find Full Text PDF

Alfalfa represents one of the most important legume forages, and it is also applied as an organic fertilizer to improve soil quality. However, this perennial plant is native to warmer temperate regions, and its valuable cold-acclimation-related regulatory mechanisms are still less known. In higher plants, the transcription factors play pleiotropic regulatory roles in response to abiotic stresses.

View Article and Find Full Text PDF