New insight into the exotic states strongly coupled with the DD‾ from the T.

We have investigated the internal structure of the open- and hidden-charmed (DD/D¯D) molecules in the unified framework. We first fit the experimental lineshape of the T state and extract the DD interaction, from which the T is assumed to arise solely. Then we obtain the DD¯ interaction by charge conjugation.

Novel Coupled Channel Framework Connecting the Quark Model and Lattice QCD for the Near-threshold D_{s} States.

A novel framework is proposed to extract near-threshold resonant states from finite-volume energy levels of lattice QCD and is applied to elucidate structures of the positive parity D_{s}. The quark model, the quark-pair-creation mechanism and D^{(*)}K interaction are incorporated into the Hamiltonian effective field theory. The bare 1^{+} cs[over ¯] states are almost purely given by the states with heavy-quark spin bases.

Implications of the Z(3985) and Z(4000) as two different states.

Recently, the hidden charm tetraquark states Z(3985) and Z(4000) with strangeness were observed by the BESIII and LHCb collaborations, respectively, which are great breakthroughs for exploring exotic quantum chromodynamics (QCD) structures. The first and foremost question is whether they are the same state. In this work, we explore the implications of the narrower state Z(3985) in BESIII and the wider one Z(4000) in LHCb as two different states.

Identification of acquired PIGA mutations and additional variants by next-generation sequencing in paroxysmal nocturnal hemoglobinuria.

Introduction: Paroxysmal Nocturnal Hemoglobinuria (PNH) is an acquired clonal disease of hematopoietic stem cells. It is caused by somatic mutation of the X-linked PIGA gene, resulting in a deficient expression of glycosylphosphatidylinositol-anchored proteins (GPI-APs). In this study, we aimed to explore the diagnostic value of next-generation sequencing (NGS) and potential molecular basis in PNH patients.

Survey of miRNA-miRNA cooperative regulation principles across cancer types.

Cooperative regulation among multiple microRNAs (miRNAs) is a complex type of posttranscriptional regulation in human; however, the global view of the system-level regulatory principles across cancers is still unclear. Here, we investigated miRNA-miRNA cooperative regulatory landscape across 18 cancer types and summarized the regulatory principles of miRNAs. The miRNA-miRNA cooperative pan-cancer network exhibited a scale-free and modular architecture.

LncMAP: Pan-cancer atlas of long noncoding RNA-mediated transcriptional network perturbations.

Gene regulatory network perturbations contribute to the development and progression of cancer, however, molecular determinants that mediate transcriptional perturbations remain a fundamental challenge for cancer biology. We show that transcriptional perturbations are widely mediated by long noncoding RNAs (lncRNAs) via integration of genome-wide transcriptional regulation with paired lncRNA and gene expression profiles. Systematic construction of an LncRNA Modulator Atlas in Pan-cancer (LncMAP) reveals distinct types of lncRNA regulatory molecules, which are expressed in multiple tissues, exhibit higher conservation.

Identifying and functionally characterizing tissue-specific and ubiquitously expressed human lncRNAs.

Recent advances in transcriptome sequencing have made it possible to distinguish ubiquitously expressed long non-coding RNAs (UE lncRNAs) from tissue-specific lncRNAs (TS lncRNAs), thereby providing clues to their cellular functions. Here, we assembled and functionally characterized a consensus lncRNA transcriptome by curating hundreds of RNA-seq datasets across normal human tissues from 16 independent studies. In total, 1,184 UE and 2,583 TS lncRNAs were identified.