Lamb wave based damage imaging under nonlinear chirp excitation.

Considering a trade-off between temporal-spatial resolution and multi-mode nature of Lamb waves, tone bursts with short durations are usually used as excitations in Lamb wave based damage detection. A short-duration excitation usually requires a large amplitude to carry sufficient energy so as to obtain response signals with enough signal-to-noise ratio and cover a large inspection area. In this paper, an alternative Lamb wave damage imaging method using nonlinear chirp (nonlinear frequency modulation, NLFM) excitation with a long duration and a small amplitude is proposed.

Improvement in the performance of an autoantibody panel in combination with heat shock protein 90a for the detection of early‑stage lung cancer.

The early diagnosis of lung cancer is closely associated with the decline of mortality. A panel consisting of seven lung cancer-related autoantibodies (7-AABs) has been shown to be a reliable and specific indicator for the early detection of lung cancer, with a specificity of ~90% and a positive predictive value of ~85%. However, its low sensitivity and negative predictive value limit its wide application.

Combination of Circulating Cell-Free DNA and Positron Emission Tomography to Distinguish Non-Small Cell Lung Cancer from Tuberculosis.

Objective: Non-small cell lung cancer (NSCLC) holds high metabolic tumor burden and circulating cell-free DNA (cfDNA) levels, and the relationship between metabolic tumor burden and cfDNA in NSCLC and the underlying mechanism of their interaction therein remain poorly characterized. Our aim was to evaluate the clinical value of cfDNA and metabolic tumor burden by positron emission tomography-computed tomography (PET/CT) for NSCLC differential diagnosis from tuberculosis in patients with solitary pulmonary nodules.

Methods: Metabolic tumor burden values in humans (subjects with NSCLC, subjects with tuberculosis, and healthy control subjects) and relevant mouse models were detected by preoperative 18F-fluorodeoxyglucose PET (18F-FDG PET/CT) and [3H]-2-deoxy-DG uptake, respectively.

Blood vessel assessment using computed tomography : Effects of ephedrine on uterine artery.

Background: Ephedrine increased blood pressure due to the contractile properties of resistance vessels. Excessive contraction of the uterine arteries might cause fetal distress. This study was to determine the diameter of the uterine artery of female New Zealand rabbits after the administration of different doses of ephedrine using CT.

Characterization of interfacial property of a two-layered plate using a nonlinear low-frequency Lamb wave approach.

This work investigates the feasibility of using a nonlinear low-frequency Lamb wave approach for characterizing the interfacial property of a two-layered plate. Compared with the case of the exact phase-velocity matching, the approximate phase-velocity matching in the low-frequency region can still guarantee the cumulative second-harmonic generation (SHG) of primary Lamb wave propagation, which overcomes the drawbacks arising from the inherent dispersion and multimode features of Lamb wave propagation. For a given two-layered plate, the appropriate mode pair at low frequency consisting of primary Lamb wave and double-frequency Lamb wave (DFLW), which satisfies the approximate phase-velocity matching and nonzero energy flux, is selected to ensure that the amplitude of the generated second harmonic grows within the maximum cumulative distance (MCD).

Experimental observation of static component generation by Lamb wave propagation in an elastic plate.

The experimental observation of acoustic radiation induced static component (SC) generation by Lamb wave propagation in an elastic plate is first reported. An experimental approach to directly detect the generated SC of primary Lamb wave propagation in an elastic plate is proposed, where a low-frequency wedge transducer is used to detect the SC pulse generated by primary Lamb wave tone-burst that is excited by a high-frequency wedge transducer. The basic requirements are that the group velocity of primary Lamb wave needs to be equal to that of the s mode at zero frequency (i.

Modeling and simulation of static component generation of Lamb wave propagation in a layered plate.

Modeling of the acoustic-radiation-induced static component (SC) generation of primary Lamb wave tone burst propagating in a layered plate is conducted. Accompanying the propagation of primary Lamb wave tone burst, there are the finite-duration SC bulk driving force in the interior of the layered plate, and the finite-duration SC traction stress on each surface/interface. According to the modal analysis approach for waveguide excitation, the function of the finite-duration SC bulk driving force and traction stress is to generate the finite-duration SC of primary Lamb wave tone burst.

A report of clinical diagnosis and treatment of nine cases of coronavirus disease 2019.

Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 has become an important public health issue in the world. More than 118 000 cases were confirmed around the world. The main clinical manifestations were respiratory symptoms and occasional gastrointestinal symptoms.

Modeling and simulation of frequency mixing response of two counter-propagating Lamb waves in a two-layered plate.

This work investigates modeling of the frequency mixing response (FMR) induced by two counter-propagating Lamb waves with different frequencies in a two-layered plate, and then numerically simulates and analyzes the influences of interfacial properties on the effect of FMR. Based on a perturbation approach and a normal-mode-expansion technique for waveguide excitation, the second-order bulk driving forces and surface/interface stresses at the mixing frequency, originated from the interaction of two counter-propagating Lamb waves within the wave mixing zone, can be regarded as the excitation sources for generation of a series of combined harmonics. It is found that, under the internal resonance condition including the phase matching and nonzero energy flux, the magnitude of the combined harmonic generated increases with increase in the length of mixing zone of the two counter-propagating Lamb waves, and tends to be stable outside the wave mixing zone.

Mode pair selection of circumferential guided waves for cumulative second-harmonic generation in a circular tube.

The appropriate mode pairs of primary and double-frequency circumferential guided waves (CGWs) have been investigated and selected for generation of the cumulative second harmonics, which are applicable for quantitative assessment of damage/degradation in a circular tube. The selection criteria follow the requirements: the higher efficiency of cumulative second-harmonic generation (SHG) of primary CGW propagation, and the larger response sensitivity of cumulative SHG to material damage/degradation [characterized by variation in the third-order elastic (TOE) constants]. The acoustic nonlinearity parameter β of CGW propagation and the change rate of normalized β versus the TOE constants of tube material are, respectively, used to describe the efficiency of SHG and its response sensitivity to damage/degradation.

Assessment of accumulated damage in circular tubes using nonlinear circumferential guided wave approach: A feasibility study.

The feasibility of using the nonlinear effect of primary Circumferential Guided Wave (CGW) propagation for assessing accumulated damage in circular tubes has been investigated. For a given circular tube, an appropriate mode pair of fundamental and double frequency CGWs is chosen to enable that the second harmonic of the primary wave mode can accumulate along the circumferential direction. After the given circular tube is subjected to compression-compression repeated loading for different numbers of loading cycles, the corresponding ultrasonic measurements are conducted.