Biodegradable copper-doped calcium phosphate nanoplatform enables tumor microenvironment modulations for amplified ferroptosis in cervical carcinoma treatment.

As a recently discovered form of regulated cell death, ferroptosis has attracted much attention in the field cancer therapy. However, achieving considerably enhanced efficacy is often restricted by the overexpression of endogenous glutathione (GSH) in tumor microenvironment (TME). In this work, we report a ferroptosis-inducing strategy of GSH depletion and reactive oxygen species (ROS) generation based on a biodegradable copper-doped calcium phosphate (CaP) with L-buthionine sulfoximine (BSO) loading (denoted as BSO@CuCaP-LOD, BCCL).

SNPs are related to colorectal cancer susceptibility and survival in Chinese people.

SNPs may increase transcription and KRAS levels. SNPs of 3'UTR can affect carcinoma risk and prognosis. The rs8720 and rs7960917 in 3'UTR for colorectal carcinoma (CRC) risk and survival were investigated in a case-control study.

Albumin-MnO gated hollow mesoporous silica nanosystem for modulating tumor hypoxia and synergetic therapy of cervical carcinoma.

Currently, some approaches in cancer therapy have gradually shifted from a focus on monotherapy to combined therapy, which results in considerable superadditive therapeutic effects. Herein, bovine serum albumin integrated manganese dioxide nanoparticles (BSA-MnO) was synthesized via a biomineralization strategy. Then, the BSA-MnO nanoparticles was anchored on the surface of the chemotherapeutic drug doxorubicin (DOX) and photosensitizer chlorine e6 (Ce6) co-loaded hollow mesoporous silica nanospheres (BSA-MnO@HMSNs-DOX-Ce6, BMHDC) through the formation of disulfide bonds.

Graphene quantum dots-gated hollow mesoporous carbon nanoplatform for targeting drug delivery and synergistic chemo-photothermal therapy.

Background: Carbon-based drug delivery systems have attracted great interest because of their excellent photothermal conversion capability and high specific surface area for drug loading. Herein, we report a multifunctional nanoplatform based on hyaluronic acid (HA)-modified and graphene quantum dot (GQD)-gated hollow mesoporous carbon nanoparticle (HMCN) for anticancer drug encapsulation and targeted chemo-photothermal therapy of CD44 receptor-overexpressed cancer cells.

Methods: In this design, HMCN was not only used as a nanocarrier with high drug loading content to achieve chemotherapy, but also as a near-infrared absorbing agent to realize photothermal therapy.