[F]AlF-NOTA-ADH-1: A new PET molecular radiotracer for imaging of N-cadherin-positive tumors.

Background: The cell adhesion molecule (CAM) N-cadherin has become an important target for tumor therapy. The N-cadherin antagonist, ADH-1, exerts significant antitumor activity against N-cadherin-expressing cancers.

Methods: In this study, [F]AlF-NOTA-ADH-1 was radiosynthesized.

The value of PET/CT for the diagnosis and evaluation of immunotherapy in occult primary renal cell carcinoma: a case report.

Skin and soft tissue diffusion metastasis (also known as occult cancer) is rare in renal cell carcinoma (RCC). Here, we report an extremely rare case of a 67-year-old male patient with occult primary RCC who developed metastases to the gums, skin, and diffuse soft tissue. The primary renal lesion was missed by computed tomography (CT), ultrasound, and 18F-fluorodeoxyglucose positron emission tomography (PET)/CT, and the diagnosis was confirmed by biopsy of gums and subcutaneous nodules.

Development of Tc-Hynic-Adh-1 Molecular Probe Specifically Targeting N-Cadherin and Its Preliminary Experimental Study in Monitoring Drug Resistance of Non-Small-Cell Lung Cancer.

Background: N-cadherin is considered a characteristic protein of EMT and has been found to be closely related to tumor resistance. In this study, a novel molecular imaging probe, Tc-HYNIC-ADH-1, was developed, and its diagnostic value in monitoring drug resistance in NSCLC was preliminarily investigated.

Methods: ADH-1 was labeled indirectly with Tc.

Double Trap Escape: Omental Nodular Hyperplasia Misdiagnosed as Metastasis by 18F-FDG PET/CT and 68Ga-FAPI PET/MRI in a Patient With Gastric Adenocarcinoma.

A 55-year-old man was diagnosed with gastric adenocarcinoma. 18F-FDG PET/CT was performed, which detected an enlarged nodule with increased uptake located in the omentum between the transverse colon and liver, thus lymph node metastasis was under suspicion. The patient subsequently underwent 68Ga-FAPI PET/MRI clinical trial after signing the informed consent, which also revealed the abnormal focus with intense uptake.

Salvianolic acid B protects against acute and chronic liver injury by inhibiting Smad2C/L phosphorylation.

Salvianolic acid B (Sal B) has strong antioxidant and anti-fibrosis effects, which are related to the transforming growth factor β/Smad signaling pathway. However, how Sal B affects this antioxidant pathway and the phosphorylation (p-) of Smad2 at both the COOH-terminal (pSmad2C) and linker region (pSmad2L) are unknown. The aims of the present study were to investigate the underlying mechanisms of Sal B on acute and chronic liver injury induced by CCl and HO, and its effects on p-Smad2C/L.

Abnormal phosphorylation of tau protein and neuroinflammation induced by laparotomy in an animal model of postoperative delirium.

Postoperative delirium (POD) is an acute neuropsychological disturbance after surgery, whose prevalence is related with advancing age. Neuroinflammation and abnormal tau phosphorylation that commonly presenting in Alzheimer's disease (AD) may contribute to the progression and duration of POD. To study the acute influence of surgery on cognitive function, wild type male C57BL/6 N mice were randomly divided into three groups: Control (CON), Laparotomy at 4 h and 24 h (LAP-4 h, LAP-24 h), then subjected to laparotomy under sevoflurane anaesthesia.

Smad3 gene C-terminal phosphorylation site mutation aggravates CCl -induced inflammation in mice.

The expression of C-terminal phosphorylated Smad3 (pSmad3C) is down-regulated with the progression of liver disease. Thus, we hypothesized that pSmad3C expression may be negatively related to liver disease. To develop novel therapeutic strategies, a suitable animal model is required that will allow researchers to study the effect of Smad3 domain-specific phosphorylation on liver disease progression.

Benefits of F-FDG PET/CT for the preoperative characterisation or staging of disease in the ampullary and duodenal papillary.

Objectives: Diagnosing ampullary and duodenal papillary carcinomas (ADPCs) is challenging. In the present study, we investigated the application value of F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) in the preoperative evaluation of these tumours.

Methods: F-FDG PET/CT images of 58 patients with ADPC and 28 patients with benign disease were retrospectively analysed.

Primary malignant melanoma of the lung: a case report and literature review.

Background: Malignant melanoma (MM) generally presents as a primary neoplasm of the skin, and most MM cases of the respiratory system are metastatic. Primary MM of the lung (PMML) is quite rare, and its diagnosis is relatively difficult.

Case Presentation: We report the case of a 57-year-old male patient with PMML who denied any history of tumours.

Effects of temperature on the thermal conductivity of amorphous CaO-SiO-AlO slags: a computational insight.

Amorphous CaO-SiO2-Al2O3 (CSA) slags are widely used in the glass, ceramic, cement and metallurgy industries. Temperature, as an external condition, plays an important role in the thermal conductivity of silicates. Herein, the effects of temperature on the thermal conductivity of CSA slags were systematically investigated by using equilibrium molecular dynamics (EMD) simulations.

Salvianolic acid B exerts anti-liver fibrosis effects via inhibition of MAPK-mediated phospho-Smad2/3 at linker regions in vivo and in vitro.

Aim: To investigate anti-liver fibrosis effects of Salvianolic acid B (Sal B) from Salvia miltiorrhiza Bunge involved mitogen-activated protein kinase (MAPK)-mediated transforming growth factor-beta (TGF-β) signaling.

Main Methods: Diethylnitrosamine (DEN)-induced liver fibrosis in mice and TGF-β-activated hepatic stellate cells (HSCs) were established and treated with dosage/concentration-graded Sal B and/or MAPK activator (Vacquinol-1: MKK4-specific activator)/inhibitors (PD98059: ERK-specific inhibitor; SP600125: JNK-specific inhibitor; SB203580: p38-specific inhibitor). Histopathological characteristics and cell migration were assessed, α-SMA, Collagen I and members of TGF-β/MAPK/Smad signal transduction pathway were measured.

2-fluoro-2-deoxy-D-glucose positron emission tomography versus conventional imaging for the diagnosis of breast cancer and lymph node metastases.

Context: Proper preoperative staging is vital in the treatment of breast cancer patients. Fluorine-18-labeled 2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (F-FDG-PET/CT) and conventional diagnostic modalities including ultrasonography (US), mammography (MG), and magnetic resonance imaging (MRI) play a greater role.

Aims: To evaluate the diagnostic accuracy of FDG-PET in detecting primary breast cancer as compared with US, MG, and MRI, and in axillary lymph nodes (ALNs) staging in Chinese women.

Effect of Shear Stress on Isothermal Crystallization Behavior of CaO-Al₂O₃-SiO₂-Na₂O-CaF₂ Slags.

How to coordinate the contradiction between lubrication and heat transfer in the peritectic steel casting process is the key technical difficulty in preparing mold fluxes. The mold fluxes that are required for casting are subjected to the shear stress generated by mold oscillation and slab movement, which affects the crystallization performance of slags. The quantitative effect of slags’ crystallization performance by shear stress is studied to develop a low-basicity and high-crystallization mold flux to solve the above problem.

A Novel Approach for Evaluating the Contraction of Hypo-Peritectic Steels during Initial Solidification by Surface Roughness.

The contraction of peritectic steels in the initial solidification has an important influence on the formation of surface defects of continuously cast slabs. In order to understand the contraction behavior of the initial solidification of steels in the mold, the solidification process and surface roughness in a commercial hypo-peritectic and several non-peritectic steels were investigated using Confocal Scanning Laser Microscope (CSLM). The massive transformation of delta-Fe (δ) to austenite (γ) was documented in the hypo-peritectic steel, which caused surface wrinkles and greatly increases the surface roughness of samples in the experiments.

Early monitoring of osteoporosis treatment response by technetium-99m-methylene diphosphonate bone scan.

Objective: The aim of this study was to investigate the effectiveness of a technetium-99m-methylene diphosphonate (Tc-MDP) bone scan and the bone mineral density (BMD) test in monitoring the efficacy of osteoporosis (OP) treatment.

Patients And Methods: A total of 50 women with OP were prospectively enrolled in this study from January 2011 to October 2016 in our hospital. All the patients underwent a Tc-MDP whole-body bone scan and the BMD test before and after alendronate sodium treatment at 3, 6, 12 and 18 months, respectively.

[Raman Spectroscopic Study of the Structure of CaO-SiO2-Al2O3-Based Flux].

Due to the [Al] reaction with the CaO-SiO2-based mold flux used in the high-Al steels continuous casting processes, decreasing the SiO2 content is decreased and the Al2O3 content in mold flux is increased, thus converting the original CaO-SiO2-based mold flux into a CaO-SiO2-Al2O3-based mold flux. This conversion of the mold fluxes can cause the problem of high-Al steels continuous casting. Hence, study on the structural characteristics of the CaO-SiO2-Al2O3- based mold flux can provide fundamental data to design optimum fluxes for high Al-containing steels.

The value of anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid PET/CT in the diagnosis of recurrent prostate carcinoma: a meta-analysis.

Background: Anti-1-amino-3-[18F]fluorocyclobutane-1-carboxylic acid (anti-3-18F-FACBC) positron emission tomography/computed tomography (PET/CT), 11 C-choline PET/CT, 111In-capromab pendetide, and T2-weighted magnetic resonance imaging (MRI) have been used for detecting prostate carcinoma relapse.

Purpose: To systematically review and perform a meta-analysis of published data regarding the performance of 18F-FACBC PET/CT in the diagnosis of recurrent prostate carcinoma.

Material And Methods: A comprehensive review of the literature regarding the role of 18F-FACBC PET/CT in the diagnosis of recurrent prostate carcinoma was performed.

[Standard uptake value of 18F-fluorine-2-deoxyglucose is correlated with the expression of estrogen receptor in duct carcinoma of breast].

Objective: To explore the relationship between the standard uptake value (SUV) of 18F-fluorine-2-deoxyglucose (18F-FDG) and the expression of estrogen receptor (ER) in duct carcinoma of breast, as well as their correlation.

Methods: From March 2004 to November 2006, PET/CT scans were performed to 41 patients (female, mean age (55.2 +/- 9.

[Preliminarily experimental study on biological properties of 153Sm-citrate-nano-Hydroxyapatite].

Objective: To investigate the biological character of new agent 153Sm-citrate-nano-Hydroxyapatite (nano-HA) in vitro and in vivo, and to explore a new radiopharmaceutical for the target therapy of bone metastasis cancer.

Methods: The nano-HA was synthesized by collosol-gelatum method, and evaluated by transmission electron microscopy (TEM) and X-ray diffraction (XRD). 153Sm was produced at a high specific activity and excellent radionuclidic purity, with which nano-HA was labeled by citrate transfer ligands in the best environment.