Publications by authors named "Guanghai Tang"
Background: There are few proven treatments for acute spontaneous intracerebral haemorrhage, and they all target reducing expansion of the haematoma. The traditional Chinese medicine FYTF-919 (Zhongfeng Xingnao) in an oral solution is comprised of several Chinese herbs that are widely used to treat patients with intracerebral haemorrhage in China on the understanding that they enhance resorption of the haematoma and reduce neuroinflammation. We aimed to provide a reliable assessment of the safety and efficacy of FYTF-919 in patients with moderate to severe acute intracerebral haemorrhage.
View Article and Find Full Text PDFArticle Synopsis
- Intracerebral hemorrhage (ICH) can cause inflammation in the body, but how this affects patients is not fully understood.
- In a study with 55 ICH patients and 20 healthy people, scientists looked at 92 proteins related to inflammation to see how they relate to stroke severity and patient outcomes.
- They found six proteins increased and 74 decreased in ICH patients, which might help predict how severe the stroke is and how well patients do afterward.
Introduction: The traditional Chinese medicine (TCM) herbal compound FYTF-919 (Zhong Feng Xing Nao prescription) may improve outcome from acute intracerebral hemorrhage (ICH) by reducing brain edema, hematoma absorption, and enhancement of the immune system. We outline the statistical analysis plan (SAP) for the Chinese Herbal medicine in Acute INtracerebral haemorrhage (CHAIN) study.
Design: CHAIN is a multicenter, prospective, randomized, double-blind, placebo-controlled trial being undertaken at 20-30 hospitals in China.
Article Synopsis
- Early control of high blood pressure is crucial in treating acute intracerebral hemorrhage, and the study aimed to evaluate a comprehensive care bundle to improve patient outcomes in various hospitals globally.
- The research was conducted in nine low- and middle-income countries and one high-income country using a randomized controlled trial design, focusing on hospitals without existing effective protocols for treating this condition.
- The care bundle emphasized rapid blood pressure reduction, glucose management, and other key interventions for patients presenting with spontaneous intracerebral hemorrhage within six hours of symptom onset.
Objective: In this study, we aimed to explore the alterations in gut microbiota composition and cytokine responses related to disease progression, severity, and outcomes in patients with hypertensive intracerebral hemorrhage (ICH).
Methods: Fecal microbiota communities of 64 patients with ICH, 46 coronary heart disease controls, and 23 healthy controls were measured by sequencing the V3-V4 region of the 16S ribosomal RNA (16S rRNA) gene. Serum concentrations of a broad spectrum of cytokines were examined by liquid chips and ELISA.
Due to the availability of materials and low cost for production, fused deposition modeling is becoming the most widely used additive manufacturing (AM) technology. However, the reasonable choice of process parameters for FDM is a significant task that directly affects the performance of the printed part. Therefore, it is necessary to investigate the influences of various process parameters on the quality characteristics of the components.
View Article and Find Full Text PDFObjective: To evaluate the safety and efficacy of removing blood stasis (RBS) herbal medicine for the treatment of acute intracerebral haemorrhage (AICH) within a 6-hour time window.
Study Design: A randomised, multicentre, double-blind, placebo-controlled study performed in 14 hospitals in China.
Participants And Interventions: Patients with AICH were randomly assigned to receive a placebo, the ICH-1 (Intracerebral Haemorrhage) formula (eight herbs, including the RBS herbs and ) or the ICH-2 formula (six herbs without the RBS herbs and ) within 6 hours of ICH onset.