The Aggregation of Destabilized Ag Triangular Nanoplates and Its Application in Detection of Thiram Residues.

An aggregation or assembly of Ag triangular nanoplates (Ag TNPs) can cause dramatic changes in their optical properties, which is widely used in applications in the field of sensing. The assembly forms of nanoparticles are crucial for obtaining sensitive sensing signals, but it is unknown what kind of assembly dominates the aggregated Ag TNPs in aqueous solutions. Herein, using thiram-induced Ag TNP aggregation as a model, six different assembly models were established, including three planar (side-by-side, side-to-tip, and tip-to-tip) assemblies and three tridimensional (plane-to-plane, plane-to-tip, and plane-to-side) assemblies.

Beta-catenin mediates the apoptosis induction effect of celastrol in HT29 cells.

Aim: We evaluated the apoptosis induction effects of celastrol in human colorectal cancer cell line HT29 in WNT/beta-catenin pathway.

Main Methods: HT29 cells were treated with various concentrations (10-100μM) for 24h, MTT assay was performed to examine the effect of celastrol on growth inhibition of HT29 cells. Beta-catenin siRNA was used for transfection of cells.

Design and synthesis of a gossypol derivative with improved antitumor activities.

A novel chemical process has been devised for the synthesis of a new derivative of gossypol, 6,7,6',7'-tetrahydroxy-5,5'-diisopropyl-3,3'-dimethyl-[2,2']binaphthalenyl-1,4,1',4'-tetraone (Apogossypolone). This new process has only four steps, with a shorter synthesis span, a simple purification process, and improved yield and quality. The structure of apogossypolone was characterized by( 1)H-nuclear magnetic resonance, (13)C-nuclear magnetic resonance, mass spectroscopy, infrared spectroscopy, and elemental analysis.