Effect of sodium bicarbonate infusion on hospital mortality in acute kidney injury patients with metabolic acidosis.

Background: Physicians usually consider that sodium bicarbonate (SB) infusion can be used for metabolic acidosis; however, there is little evidence available to assess its effect on hospital mortality in large AKI cohorts. Here, we investigated the effect of SB infusion in patients with AKI complicated by metabolic acidosis.

Method: Patients with AKI complicated by metabolic acidosis were screened from the MIMIC-IV database.

Increased expression of the P2Y receptor is involved in the failure of autogenous arteriovenous fistula caused by stenosis.

Objective: This study investigated the role of the P2Y receptor in autogenous arteriovenous fistula (AVF) failure resulting from stenosis.

Methods: Stenotic venous tissues and blood samples were obtained from patients with end-stage renal disease (ESRD) together with AVF stenosis, while venous tissues and blood samples were collected from patients with ESRD undergoing initial AVF surgery as controls. Immunohistochemistry and/or immunofluorescence techniques were utilized to assess the expression of P2Y, transforming growth factor-β1 (TGF-β1), monocyte chemotactic protein 1 (MCP-1), and CD68 in the venous tissues.

Identifying the molecular mechanisms of sepsis-associated acute kidney injury and predicting potential drugs.

To provide insights into the diagnosis and therapy of SA-AKI ferroptosis genes. Based on three datasets (GSE57065, GSE30718, and GSE53771), we used weighted co-expression network analysis to identify the key regulators of SA-AKI, its potential biological functions, and constructed miRNA‒mRNA complex regulatory relationships. We also performed machine learning and cell experiments to identify ferroptosis genes that are significantly related to SA-AKI in the two datasets.