Mechanisms for more efficient antibiotics and antibiotic resistance genes removal during industrialized treatment of over 200 tons of tylosin and spectinomycin mycelial dregs by integrated meta-omics.

To mitigate the environmental risks posed by the accumulation of antibiotic mycelial dregs (AMDs), this study first attempted over 200 tons of mass production fermentation (MP) using tylosin and spectinomycin mycelial dregs alongside pilot-scale fermentation (PS) for comparison, utilizing the integrated-omics and qPCR approaches. Co-fermentation results showed that both antibiotics were effectively removed in all treatments, with an average removal rate of 92%. Antibiotic resistance gene (ARG)-related metabolic pathways showed that rapid degradation of antibiotics was associated with enzymes that inactivate macrolides and aminoglycosides (e.

Manifold Interpolation for Large-Scale Multiobjective Optimization via Generative Adversarial Networks.

Large-scale multiobjective optimization problems (LSMOPs) are characterized as optimization problems involving hundreds or even thousands of decision variables and multiple conflicting objectives. To solve LSMOPs, some algorithms designed a variety of strategies to track Pareto-optimal solutions (POSs) by assuming that the distribution of POSs follows a low-dimensional manifold. However, traditional genetic operators for solving LSMOPs have some deficiencies in dealing with the manifold, which often results in poor diversity, local optima, and inefficient searches.