Publications by authors named "Guangdong Wen"

Article Synopsis
  • Vulvar lichen sclerosus (VLS) is a chronic skin condition leading to physical and emotional challenges, but its cause is still unclear, with possible links to the microbiomes of the vulvar skin, gut, and vagina.* -
  • A study compared the microbiota of six VLS patients with five healthy controls, using sequencing techniques to evaluate differences in bacterial diversity and abundance.* -
  • Results showed notable microbiota differences, such as increased specific bacteria in VLS patients’ vulvar skin and gut, while certain beneficial bacteria were reduced, indicating potential microbial alterations linked to the condition.*
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Purpose: To investigate the cosmetic outcomes of secondary intention healing of small (<1.5cm) nasal ala and tip defects.

Patients And Methods: From August 2017 to October 2020, 42 patients with nasal reconstructions using secondary intention healing were included.

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Cutaneous metastases are rare and often portend the aggressive malignancy and poor prognosis. We report a case of a 62-year-old man with a rapidly growing nodule on the left back for 2 months. The patient was diagnosed with lung adenocarcinoma shortly before the skin lesion presented.

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Squamous cell carcinoma of the nail unit (SCCNU) is a relatively uncommon tumor with a low rate of metastasis. SCCNU presents with nonspecific symptoms and signs, it is frequently misdiagnosed by dermatologists or surgeons. We report a patient with right-hand ring subungual squamous cell carcinoma who received inappropriate treatment due to a long-term misdiagnosis following trauma.

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Background: Porokeratosis is a rare, acquired, or inherited disorder of keratinization. There are numerous clinical types of porokeratosis and they can coexist in one patient and multiple members of an affected family. However, coexistence of disseminated superficial actinic porokeratosis (DSAP) and porokeratosis ptychotropica (Ppt) is rare.

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Pilomatricoma, also known as "benign calcifying epithelioma", is an uncommon slow-growing benign adnexal skin tumor, which originates from primitive cells of the hair matrix and usually appears as a solitary, firm, and asymptomatic nodule beneath the skin. Bullous pilomatricoma is a rare form of pilomatricoma, always presenting with firm subcutaneous nodules with a bullous appearance. In this study, we report a 9-year-old Chinese presenting girl with bullous pilomatricoma after influenza vaccination.

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Article Synopsis
  • - Monilethrix is a rare genetic disorder leading to fragile and beaded hair, typically inherited in an autosomal dominant manner, though an autosomal recessive form related to the DSG4 gene has also been reported.
  • - A study focused on three Chinese families with the autosomal recessive form of monilethrix, utilizing DNA sequencing and other techniques to identify genetic variants in the DSG4 gene.
  • - Findings showed patients had sparse, fragile hair and specific hair shaft abnormalities, with several identified variants in the DSG4 gene, contributing to the understanding of the disorder's genetic basis and its clinical features.
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Trichilemmal carcinoma (TC) is a rare malignant cutaneous adnexal neoplasm originating from the outer root sheath of hair follicles, which occurs commonly in sun-exposed areas of the elderly. Here, we introduce a case of a 24-year-old woman with TC on her scalp.

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Psoriasis is one of the most common chronic inflammatory skin diseases that affects approximately 3% of the world's population. Hyper proliferation, infiltration of inflammatory cells and aberrant differentiation of keratinocytes are the three most important characteristics of psoriasis. Previous reports showed that NF-κBis the crucial mediator linking psoriatic keratinocytes and immune cell states through its effects on chemokine and cytokine production.

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Background: Graft-versus-host disease (GVHD) has various cutaneous manifestations. Little is known about the mechanisms of cutaneous GVHD with different clinical features.

Objective: To characterize the immunologic features and skin barrier functions of cutaneous GVHD.

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Textile dyeing sludge is complex hazardous material with increasing amount year by year, and the conventional treatment techniques are limited by many drawbacks such as water/soil contamination, incomplete degradation of hazardous organics or inefficient fixation of toxic heavy metals. This work reported the first example of thermal plasma gasification treatment of textile dyeing sludge in a homemade rotating arc plasma reactor, which not only significantly reduced the volume and eliminated the safety risk of textile dyeing sludge, but also produced valuable syngas that can be used for chemical industry. At a feed rate of 36 g/min and a CO flow rate of 0.

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Objective To establish a method for primary culture of adult dermal fibroblasts. Methods Fresh skin tissues were digested with dispase II to separate the epidermis from dermis. Then fibroblasts were isolated from the dermis by tissue-adhesive and type I collagenase digestion method respectively.

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Background: Graft-versus-host disease (GVHD) is a common complication of hematopoietic stem cell transplantation. Skin barrier disruption could induce thymic stromal lymphopoietin (TSLP) expression, and the expression of TSLP was increased in lesions of atopic dermatitis (AD)-like GVHD and lichen planus (LP)-like GVHD. This study attempted to investigate the skin barrier function of AD-like GVHD and LP-like GVHD and possible mechanisms.

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Article Synopsis
  • - Acne inversa (AI) is a chronic skin disease caused by mutations in γ-secretase genes, and this study focuses on two Chinese families with a hereditary form of AI.
  • - Affected individuals showed symptoms like comedones, scarring, and inflammatory nodules, with some cases resembling Dowling-Degos disease, and one individual developed anal canal squamous cell carcinoma.
  • - The study identified two new mutations in the PSENEN gene, potentially contributing to our understanding of AI and its genetic variations.
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Genome-wide association studies (GWASs) have reproducibly associated ∼40 susceptibility loci with psoriasis. However, the missing heritability is evident and the contributions of coding variants have not yet been systematically evaluated. Here, we present a large-scale whole-exome array analysis for psoriasis consisting of 42,760 individuals.

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To explore the contribution of functional coding variants to psoriasis, we analyzed nonsynonymous single-nucleotide variants (SNVs) across the genome by exome sequencing in 781 psoriasis cases and 676 controls and through follow-up validation in 1,326 candidate genes by targeted sequencing in 9,946 psoriasis cases and 9,906 controls from the Chinese population. We discovered two independent missense SNVs in IL23R and GJB2 of low frequency and five common missense SNVs in LCE3D, ERAP1, CARD14 and ZNF816A associated with psoriasis at genome-wide significance. Rare missense SNVs in FUT2 and TARBP1 were also observed with suggestive evidence of association.

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Background: Human piebaldism is a rare autosomal dominant condition characterized by congenital white forelock and depigmented patches of skin, typically on the forehead, anterior trunk and extremities. Mutations in the KIT gene have been proposed to be responsible for the underlying changes in this disorder. The aim of this study was to identify gene mutation in a Chinese family with piebaldism.

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Non-alpha-tocopherols are hydroxymethylated and hydrogenated to produce alpha-tocopherol in one pot process by simultaneously reacting with paraformaldehyde and hydrogen in the presence of catalysts of benzenesulfonic acid and 5% Pd/C in an autoclave. Effects of various operation conditions have been studied. The preferable reaction conditions are: temperature 180 degrees C to 200 degrees C, pressure 5.

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