Publications by authors named "Guangdong Ren"
Article Synopsis
- Endothelial dysfunction plays a key role in the severity of sepsis, and GAB1 has the potential to reduce multi-organ damage caused by this condition.
- GAB1 levels decrease in endothelial cells under sepsis conditions, but enhancing GAB1 expression improves cell viability, reduces apoptosis, and regulates inflammation and nitric oxide production in these cells.
- The study suggests that GAB1 protects against sepsis-induced endothelial injury through the SOCS3/JAK2/STAT3 signaling pathway, indicating its therapeutic potential in managing sepsis.
In this study, we investigated the effects of remote ischemic preconditioning on post resuscitation cerebral function in a rat model of cardiac arrest and resuscitation. The animals were randomized into six groups: 1) sham operation, 2) lateral ventricle injection and sham operation, 3) cardiac arrest induced by ventricular fibrillation, 4) lateral ventricle injection and cardiac arrest, 5) remote ischemic preconditioning initiated 90min before induction of ventricular fibrillation, and 6) lateral ventricle injection and remote ischemic preconditioning before cardiac arrest. Reagent of Lateral ventricle injection is neuroglobin antisense oligodeoxynucleotides which initiated 24h before sham operation, cardiac arrest or remote ischemic preconditioning.
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