Zn-Doped Hollow Cubic MnO as a High-Performance Cathode Material for Zn Ion Batteries.

Manganese-based compounds have the characteristics of high theoretical capacity, low cost and stable performance, thus become a research hotspot for cathode materials of zinc-ion batteries (ZIBs). However, in the process of charging and discharging, it is accompanied by problems such as structural collapse and low conductivity, which resulted in severe capacity degration during cycles. In this paper, a kind of Zn doped MnO hollow cube cathode material (Zn-MnO) was prepared by self-sacrificing template method.

From immune checkpoints to therapies: understanding immune checkpoint regulation and the influence of natural products and traditional medicine on immune checkpoint and immunotherapy in lung cancer.

Lung cancer is a disease of global concern, and immunotherapy has brought lung cancer therapy to a new era. Besides promising effects in the clinical use of immune checkpoint inhibitors, immune-related adverse events (irAEs) and low response rates are problems unsolved. Natural products and traditional medicine with an immune-modulating nature have the property to influence immune checkpoint expression and can improve immunotherapy's effect with relatively low toxicity.

Research on different compound combinations of Realgar-Indigo naturalis formula to reverse acute promyelocytic leukemia arsenic resistance by regulating autophagy through mTOR pathway.

Ethnopharmacological Relevance: In China, the Chinese patent drug Realgar-Indigo naturalis Formula (RIF) is utilized for the therapy of acute promyelocytic leukemia (APL). Comprising four traditional Chinese herb-Realgar, Indigo naturalis, Salvia miltiorrhiza, and Pseudostellaria heterophylla-it notably includes tetra-arsenic tetra-sulfide, indirubin, tanshinone IIa, and total saponins of Radix Pseudostellariae as its primary active components. Due to its arsenic content, RIF distinctly contributes to the therapy for APL.

The role of Shenqi Fuzheng injection as adjuvant therapy for breast cancer: an overview of systematic reviews and meta-analyses.

Background: Breast cancer (BC) is the most frequent malignancy in the world. Chemotherapy (CT) is a common treatment for BC but is accompanied by toxicity and side effects. Shenqi Fuzheng Injection (SFI) is an adjuvant therapy with promising results in improving efficacy and reducing toxicity in clinical studies.

Fine-Tuned Active Layer Morphology for Bulk Heterojunction Organic Solar Cells with Indene-C60 Bisadduct as a Third Component.

Active layer morphology is of vital importance for the photovoltaic performance of organic solar cells (OSCs). As fullerene derivatives and nonfullerene acceptors are highly complementary in many aspects, fullerene derivatives as a third component in nonfullerene OSCs could tune the blend morphology and improve the power conversion efficiency (PCE). Relative to PCBM, the indene-C60 bisadduct (ICBA) as the third component in nonfullerene binary OSCs has not been extensively studied.

Injectable Self-Harden Antibiofilm Bioceramic Cement for Minimally Invasive Surgery.

There is an urgent demand for antibacterial bone grafts in clinics. Worryingly, the misuse and overuse of antibiotics accelerate the emergence of drug-resistant bacteria. Therefore, this study prepared a novel injectable bioceramic cement without antibiotics (FS-BCS), which showed good antibacterial properties by loading iron and strontium onto a matrix composed of brushite and calcium sulfate.

Black phosphorus-incorporated novel Ti-12Mo-10Zr implant for multimodal treatment of osteosarcoma.

The repair and reconstruction of large bone defects after bone tumor resection is still a great clinical challenge. At present, orthopedic implant reconstruction is the mainstream treatment for repairing bone defects. However, according to clinical feedback, local tumor recurrence and nonunion of bone graft are common reasons leading to the failure of bone defect repair and reconstruction after bone tumor resection, which seriously threaten the physical and mental health of patients.

Exploring the Mechanism of Single-Crystal MnO as Cathodes for Zinc Ion Batteries.

MnO has the advantages of low cost and abundant resources, so it is considered to be an important electrode material in zinc ion batteries. However, its practical application is still challenged by easy collapse and capacity loss. In this paper, a stable single crystal β-MnO nanorod cathode material was prepared.

Channel Prediction-Based Security Authentication for Artificial Intelligence of Things.

The emerging physical-layer unclonable attribute-aided authentication (PLUA) schemes are capable of outperforming traditional isolated approaches, with the advantage of having reliable fingerprints. However, conventional PLUA methods face new challenges in artificial intelligence of things (AIoT) applications owing to their limited flexibility. These challenges arise from the distributed nature of AIoT devices and the involved information, as well as the requirement for short end-to-end latency.

Comprehensive analysis of resistance mechanisms to EGFR-TKIs and establishment and validation of prognostic model.

Purpose: Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are the first-line therapy for patients with lung adenocarcinoma (LUAD) harboring activating EGFR mutations. However, the emergence of drug resistance to EGFR-TKIs remains a critical obstacle for successful treatment and is associated with poor patient outcomes. The overarching objective of this study is to apply bioinformatics tools to gain insights into the mechanisms underlying resistance to EGFR-TKIs and develop a robust predictive model.

Environmentally adaptive polysaccharide-based hydrogels and their applications in extreme conditions: A review.

Polysaccharide hydrogels are one of the most promising hydrogel materials due to their inherent characteristics, including biocompatibility, biodegradability, renewability, and easy modification, and their structure and functional designs have been widely researched to adapt to different application scenarios as well as to broaden their application fields. As typical wet-soft materials, the high water content and water-absorbing ability of polysaccharide-based hydrogels (PHs) are conducive to their wide biomedical applications, such as wound healing, tissue repair, and drug delivery. In addition, along with technological progress, PHs have shown potential application prospects in some high-tech fields, including human-computer interaction, intelligent driving, smart dressing, flexible sensors, etc.

Room-Temperature Self-Healing Conductive Elastomers for Modular Assembly as a Microfluidic Electrochemical Biosensing Platform for the Detection of Colorectal Cancer Exosomes.

Modular components for rapid assembly of microfluidics must put extra effort into solving leakage and alignment problems between individual modules. Here, we demonstrate a conductive elastomer with self-healing properties and propose a modular microfluidic component configuration system that utilizes self-healing without needing external interfaces as an alternative to the traditional chip form. Specifically, dual dynamic covalent bond crosslinks (imine and borate ester bonds) established between Polyurethane (PU) and 2-Formylbenzeneboronic acid (2-FPBA) are the key to a hard room-temperature self-healing elastomeric substrate PP (PU/2-FPBA).

Waxberry-Like MnS/Ni S as High-Efficiency Bi-Functional Catalyst for Zn-Air Batteries.

In this paper, a waxberry-like MnS/Ni S composite catalyst was designed and synthesized. In this coating structure, MnS is located inside and Ni S is wrapped on the surface to form a spherical structure. This structure makes the material show excellent stability in the electrocatalytic process.

Electrochemical Micro-Immunosensor of Cubic AuPt Dendritic Nanocrystals/TiC-MXenes for Exosomes Detection.

Exosomes are extracellular vesicles that exist in body circulation as intercellular message transmitters. Although the potential of tumor-derived exosomes for non-invasive cancer diagnosis is promising, the rapid detection and effective capture of exosomes remains challenging. Herein, a portable electrochemical aptasensor of cubic AuPt dendritic nanocrystals (AuPt DNs)/TiC assisted in signal amplification, and aptamer CD63 modified graphene oxide (GO) was immobilized on a screen-printed carbon electrode (SPCE) as the substrate materials for the direct capture and detection of colorectal carcinoma exosomes.

Improvement of Early Death in Acute Promyelocytic Leukemia: A Population-Based Analysis.

Background: Early death is a major factor of treatment failure in acute promyelocytic leukemia (APL), however, the recent trends in the incidence of early death based on the population-level are not clear. Hence, this study is aimed at describing the incidence, recent trends, causes and characteristics of early death in APL based on the real world.

Materials And Methods: APL patients diagnosed from 1986 to 2015 in the Surveillance, Epidemiology, and End Results (SEER) dataset were enrolled, and categorized based on gender, age, year of diagnosis, race, marital status, resident county and socioeconomic status (SES).

Highly stretchable, self-healing elastomer hydrogel with universal adhesion driven by reversible cross-links and protein enhancement.

Engineered hydrogels with excellent mechanical properties and multi-functionality have great potential as soft electronic skins, tissue substitutes and flexible robotic joints. However, it has been a challenge to construct multifunctional hydrogels, especially when integrating high stretchability, toughness and strength, low hysteresis, good self-healing and adhesion abilities into a hydrogel system simultaneously. Here, we successfully developed a structural hydrogel composed of a reversible covalently cross-link-based poly--(2-hydroxyethyl)acrylamide (PHEMAA) network and available plastically deformable casein micelles.

Surface modification of new innocuous Ti-Mo-Zr based alloys for biomedical applications.

To address the clinical challenges of modulus mismatch, lack of initial osteointegration and contain toxic elements towards traditional titanium and its alloys with surrounding bone tissue, a new β-type titanium alloy (Ti-12Mo-10Zr) designed by our group will be chosen as dental implant in this proposal due to its excellent properties, e.g. low young's modulus (~ 50.

High Performance Bifunctional Electrocatalysts Designed Based on Transition-Metal Sulfides for Rechargeable Zn-Air Batteries.

Due to the energy crisis by the excessive consumption of fossil fuels, Zinc-air batteries (ZABs) with high theoretical energy density have attracted people's attention. The overall performance of ZABs is largely determined by the air cathode catalyst. Therefore, it is necessary to develop high-efficiency and low-cost bifunctional catalysts to replace noble metal catalysts to promote the development of ZABs.

Hollow Capsule NiCo NS Prepared by Self-Sacrificing Template Method for High-Efficiency Bifunctional Catalyst and Its Application in Zn-Air Battery.

Exploring the application of high-efficiency bifunctional oxygen catalysts to rechargeable zinc-air batteries has been a research hotspot in recent years. We succeeded in obtaining NiCo NS with a hollow capsule structure through the self-sacrificing template method, which has a larger specific surface area and can provide more active sites for electrocatalysis relative to his solid. The introduction of S can change the valence distribution of N and the electronic structure of the M-N bond, so that NiCo NS exhibits excellent performance in the overpotential and stability of the oxygen reduction and oxygen evolution reactions.

Identification of FAM107A as a potential biomarker and therapeutic target for prostate carcinoma.

FAM107A may have a dual role in regulating the biological functions of tumors; however, its role in prostate adenocarcinoma (PRAD) remains unknown. We analyzed FAM107A expression by employing databases to clarify its potential prognostic value for PRAD, as well as its role in the pathogenesis of PRAD. We observed that the FAM107A expression level is decreased in PRAD, and the reduced expression is considerably associated with poor overall survival and progression-free survival (PFS).

Identification of Hub Genes and Small Molecule Drugs Associated with Acquired Resistance to Gefitinib in Non-Small Cell Lung Cancer.

Targeting EGFR, epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs), brings lights to the treatment of non-small cell lung cancer (NSCLC). Although T790M mutation responded as one of the main reasons of acquired resistance, still 15% of the resistance patients can't be explained by the known mechanisms. The purpose of this research was to identify some new mechanisms of gefitinib acquired resistance, and to predict small molecules drugs which may reverse drug resistance by integrated bioinformatics analysis.

CoS /N-Doped Hollow Spheres as an Anode Material for High-Performance Sodium-Ion Batteries.

In this work, we first synthesized polyacrylic acid (PAA) spheres and then used PAA as a template to load Co(OH) particles onto its surface. The product of CoS nanoparticles dispersed in N-doped hollow spheres (N-HCS) was prepared through sulfurization treatment (CoS /S@N-HCS). During the sulfuration process, sulfur penetrates into the PAA, embedding into the graphite layer along with the carbonization process.