Joint response of surface subsidence and strong mine earthquake under high-positioned and thick-hard strata in deep coal mine.

Multiple active mining faces and extensive excavations under thick-hard strata in deep coal mines result in frequent strong mine earthquakes, often accompanied by significant surface subsidence deformation. Understanding the specific law of surface movement and the spatiotemporal distribution response to intense mine earthquakes is crucial for effectively preventing and mitigating dynamic disasters in deep mines. Utilizing the key layer theory, the intricate strata of the Yingpanhao Coal Mine are systematically delineated, drawing upon the engineering context of working faces 2201 and 2202 within the Ordos Chemical Co.

Structure based release kinetics analysis of doxazosin mesylate sustained-release tablets using micro-computed tomography.

The structures of solid dosage forms determine their release behaviors and are critical attributes for the design and evaluation of the solid dosage forms. Here, the 3D structures of doxazosin mesylate sustained-release tablets were parallelly assessed by micro-computed tomography (micro-CT). There were no significant differences observed in the release profiles between the RLD and the generic formulation in the conventional dissolution, but the generic preparation released slightly faster in media with ethanol during an alcohol-induced dose-dumping test.

Difficult Airway Assessment Based on Multi-View Metric Learning.

The preoperative assessment of difficult airways is of great significance in the practice of anesthesia intubation. In recent years, although a large number of difficult airway recognition algorithms have been investigated, defects such as low recognition accuracy and poor recognition reliability still exist. In this paper, we propose a Dual-Path Multi-View Fusion Network (DMF-Net) based on multi-view metric learning, which aims to predict difficult airways through multi-view facial images of patients.

Study on the mechanism and response law of fracture movement on the super-high position hard-thick strata.

In this paper, a thick plate structural mechanical model was established for the hard-thick rock strata in the Ordos region, which was characterized by the occurrence of high-energy strong earthquakes caused by the fracture of hard-thick rock strata. Subsequently, based on Vlasov's theory, the evolution process of hard-thick rock strata was analyzed. And the paper validated the analysis results using high-energy mine earthquake and surface subsidence data.

Inflation using hydrogen improves donor lung quality by regulating mitochondrial function during cold ischemia phase.

Background: Mitochondrial dysfunction results in poor organ quality, negatively affecting the outcomes of lung transplantation. Whether hydrogen benefits mitochondrial function in cold-preserved donors remain unclear. The present study assessed the effect of hydrogen on mitochondrial dysfunction in donor lung injury during cold ischemia phase (CIP) and explored the underlying regulatory mechanism.

Impact of Regional Anesthesia on Subjective Quality of Recovery in Patients Undergoing Thoracic Surgery: A Systematic Review and Meta-Analysis.

Objectives: Regional anesthesia can be effective for managing pain after thoracic surgery. This study evaluated whether it can also improve patient-reported quality of recovery (QoR) after such surgery.

Design: Meta-analysis of randomized controlled trials.

Neural and molecular investigation into the paraventricular thalamic-nucleus accumbens circuit for pain sensation and non-opioid analgesia.

The paucity of medications with novel mechanisms for pain treatment combined with the severe adverse effects of opioid analgesics has led to an imperative pursuit of non-opioid analgesia and a better understanding of pain mechanisms. Here, we identify the putative glutamatergic inputs from the paraventricular thalamic nucleus to the nucleus accumbens (PVT→NAc) as a novel neural circuit for pain sensation and non-opioid analgesia. Our in vivo fiber photometry and in vitro electrophysiology experiments found that PVT→NAc neuronal activity increased in response to acute thermal/mechanical stimuli and persistent inflammatory pain.

Comparison of two methods for extracting exosomes from the nucleus accumbens in mice.

Background: Exosomes bind to and are endocytosed by neurons of various brain regions. Methods for isolating and extracting exosomes from specific brain samples are critical. At present, the most important extractive methods for exosomes are Ultracentrifugation and exosome isolation kit extraction.

Packaging Big Data Visualization Based on Computational Intelligence Information Design.

A method based on a computational intelligence information model is proposed to study the visualization of large data packages. Since the CAIM algorithm only considers the distribution of the largest number of classes in an interval, it offers an optimization method and simultaneously determines the appropriate stopping conditions to avoid overcrowding. The effectiveness of the improved algorithm has been experimentally proven.

Comparison of erector spinae plane and paravertebral nerve blocks for postoperative analgesia in children after the Nuss procedure: study protocol for a randomized controlled non-inferiority clinical trial.

Background: Thoracic paravertebral block (TPVB) is a widely advocated regional technique for alleviating postoperative pain in children undergoing elective pectus excavatum repair. However, this technique is associated with some undesirable adverse events. Recently, the erector spinae plane block (ESPB) has been introduced as a practical alternative to the TPVB in thoracic surgery.

Mechanical Performance of a Ballastless Track System for the Railway Bridges of High-Speed Lines: Experimental and Numerical Study under Thermal Loading.

The mechanical performance of China Railway Track System type II (CRTS II) ballastless track suitable for High-Speed Railway (HSR) bridges is investigated in this project by testing a one-quarter-scaled three-span specimen under thermal loading. Stress analysis was performed both experimentally and numerically, via finite-element modeling in the latter case. The results showed that strains in the track slab, in the cement-emulsified asphalt (CA) mortar and in the track bed, increased nonlinearly with the temperature increase.

Behaviors Related to Psychiatric Disorders and Pain Perception in C57BL/6J Mice During Different Phases of Estrous Cycle.

Robust sex difference among humans regarding psychiatry- and pain-related behaviors is being researched; however, the use of female mice in preclinical research is relatively rare due to an unchecked potential behavioral variation over the estrous cycle. In the present study, a battery of psychiatry- and pain-related behaviors are examined under physiological condition in female C57BL/6J mice over different estrous cycle phases: proestrus, estrous, metestrous, diestrous. Our behavioral results reveal that there is no significant difference over different phases of the estrous cycle in social interaction test, sucrose preference test, tail suspension test, open field test, marble burying test, novelty-suppressed feeding test, Hargreaves thermal pain test, and Von Frey mechanical pain test.

[Anatomy and clinical application of anterior and posterior terminal perforators of peroneal artery].

Objective: To investigate the anatomy of anterior and posterior terminal perforators of the peroneal artery and its clinical applications.

Methods: Six lower limb specimens were obtained from 3 fresh cadavers. The anterior and posterior terminal perforators and the perforator of terminal peroneal artery were exposed under surgical microscope, and the distances from the beginning of each perforator branch to the lateral malleolus tip and the external diameter of each perforator were measured.

[Significance of neutrophil extracellular trap and its markers in the early diagnosis of community-acquired pneumonia in children].

Objective: To study the significance of plasma neutrophil extracellular trap (NET) and its markers in the diagnosis of community-acquired pneumonia (CAP) in children.

Methods: A total of 160 children with CAP were enrolled as the CAP group, and 50 healthy children were enrolled the control group. According to disease severity, the CAP group was further divided into a mild CAP subgroup with 137 children and a severe CAP subgroup with 23 children.

[Value of simultaneous amplification and testing in early diagnosis of Mycoplasma pneumoniae pneumonia and related influencing factors].

Objective: To investigate the value of simultaneous amplification and testing (SAT) in the early diagnosis of Mycoplasma pneumoniae pneumonia (MPP) in children and related influencing factors.

Methods: A total of 526 children with community-acquired pneumonia who were hospitalized between December 2016 and December 2017 were enrolled. Particle agglutination was used to measure serum Mycoplasma pneumoniae (MP) antibody (MP-Ab).

The Anti-inflammatory Effect of Hydrogen on Lung Transplantation Model of Pulmonary Microvascular Endothelial Cells During Cold Storage Period.

Background: Lung ischemia-reperfusion injury (LIRI) remains an important factor for the early mortality of lung transplantations. Hydrogen (H2) can attenuate lung injury and improve lung function in animal experiments. In previous studies, pulmonary microvascular endothelial cells (PMVECs) were used to simulate LIRI.

Di and trinuclear rare-earth metal complexes supported by 3-amido appended indolyl ligands: synthesis, characterization and catalytic activity towards isoprene 1,4-cis polymerization.

Different di and trinuclear rare-earth metal complexes supported by 3-amido appended indolyl ligands were synthesized and their catalytic activities towards isoprene polymerization were investigated. Treatment of [RE(CHSiMe)(thf)] with 1 equiv. of 3-(CyN[double bond, length as m-dash]CH)CHNH in toluene or in THF afforded dinuclear rare-earth metal alkyl complexes having indolyl ligands in different hapticities with central metals {[η:η-μ-η-3-(CyNCH(CHSiMe))Ind]RE-(thf)(CHSiMe)} (Cy = cyclohexyl, Ind = Indolyl, RE = Yb (1), Er (2), Y (3)) or {[η-μ-η-3-(CyNCH(CHSiMe))Ind]RE-(thf)(CHSiMe)} (RE = Yb (4), Er (5), Y (6), Gd (7)), respectively.

Reactivity of functionalized indoles with rare-earth metal amides. Synthesis, characterization and catalytic activity of rare-earth metal complexes incorporating indolyl ligands.

The reactivity of several functionalized indoles 2-(RNHCH2)C8H5NH (R = C6H5 (1), (t)Bu (2), 2,6-(i)Pr2C6H3 (3)) with rare-earth metal amides is described. Reactions of 1 or 2 with [(Me3Si)2N]3RE(μ-Cl)Li(THF)3 (RE = Eu, Yb) respectively produced the europium complexes [2-(C6H5N[double bond, length as m-dash]CH)C8H5N]2Eu[N(SiMe3)2] (4) and [2-((t)BuN[double bond, length as m-dash]CH)C8H5N]Eu[N(SiMe3)2]2 (5), and the ytterbium complex [2-((t)BuN[double bond, length as m-dash]CH)C8H5N]2Yb[N(SiMe3)2] (6), containing bidentate anionic indolyl ligands via dehydrogenation of the amine to the imine. In contrast, reactions of the more sterically bulky indole 3 with [(Me3Si)2N]3RE(μ-Cl)Li(THF)3 afforded complexes [2-(2,6-(i)Pr2C6H3NCH2)C8H5N]RE[N(SiMe3)2](THF)2 (RE = Yb (7), Y (8), Er (9), Dy (10)) with the deprotonated indolyl ligand.

Synthesis and Characterization of Organo-Rare-Earth Metal Monoalkyl Complexes Supported by Carbon σ-Bonded Indolyl Ligands: High Specific Isoprene 1,4-Cis Polymerization Catalysts.

A series of N-protected 3-imino-functionalized indolyl ligands 1-R-3-(R'N═CH)C8H5N [R = Bn, R' = 2,6-(i)Pr2C6H3 (HL(1)); R = CH3, R' = 2,6-(i)Pr2C6H3 (HL(2)); R = Bn, R' = (t)Bu (HL(3))] and 1-CH3-2-(2,6-(i)Pr2C6H3N═CH)C8H5N (HL(4)) was prepared via reactions of N-protected indolyl aldehydes with corresponding amines. The C-H σ-bond metathesis followed by alkane elimination reactions between RE(CH2SiMe3)3(thf)2 and HL(1)-HL(3) afforded the carbon σ-bonded indolyl-ligated rare-earth metal monoalkyl complexes. Reactions of RE(CH2SiMe3)3(thf)2 with 2 equiv of HL(1) or HL(2) gave the carbon σ-bonded indolyl-ligated rare-earth metal monoalkyl complexes L(1)2RECH2SiMe3 (RE = Y(1), Er(2), Dy(3)) and L(2)2RECH2SiMe3 (RE = Y(5), Er(6), Dy(7), Yb(8)), while reaction of Yb(CH2SiMe3)3(thf)2 with 2 equiv of HL(1) afforded the ytterbium dialkyl complex L(1)Yb(CH2SiMe3)2(thf)2 (4).

Palladium-catalyzed Hiyama coupling reaction of arylsulfonyl hydrazides under oxygen.

Palladium-catalyzed Hiyama cross-coupling reactions of various arylsulfonyl hydrazides with a wide variety of aryl silanes have been achieved in good to excellent yields under simple conditions. The newly developed catalytic system does not require the use of expensive silver- or copper-based stoichiometric oxidants and can be accelerated by the addition of TBAT under an atmosphere of oxygen. The reported Hiyama-type coupling reactions are tolerant to common functional groups, making these transformations attractive alternatives to the traditional cross-coupling approaches.

Dinuclear rare-earth metal alkyl complexes supported by indolyl ligands in μ-η(2) :η(1) :η(1) hapticities and their high catalytic activity for isoprene 1,4-cis-polymerization.

Two series of new dinuclear rare-earth metal alkyl complexes supported by indolyl ligands in novel μ-η(2) :η(1) :η(1) hapticities are synthesized and characterized. Treatment of [RE(CH2 SiMe3 )3 (thf)2 ] with 1 equivalent of 3-(tBuN=CH)C8 H5 NH (L1 ) in THF gives the dinuclear rare-earth metal alkyl complexes trans-[(μ-η(2) :η(1) :η(1) -3-{tBuNCH(CH2 SiMe3 )}Ind)RE(thf)(CH2 SiMe3 )]2 (Ind=indolyl, RE=Y, Dy, or Yb) in good yields. In the process, the indole unit of L1 is deprotonated by the metal alkyl species and the imino C=N group is transferred to the amido group by alkyl CH2 SiMe3 insertion, affording a new dianionic ligand that bridges two metal alkyl units in μ-η(2) :η(1) :η(1) bonding modes, forming the dinuclear rare-earth metal alkyl complexes.

Rare-earth alkyl complexes supported by formamidinate ligands: synthesis, structure, and catalytic activity for isoprene polymerization.

A series of rare-earth metal monoalkyl complexes supported by N,N'-di(2,6-dialkylphenyl)formamidinate ligand (L)2RECH2SiMe3·thf [L(1) = HC(N-2,6-Me2C6H3)2, RE = Y (1), L(2) = HC(N-2,6-(i)Pr2C6H3)2, RE = Y (2), Er (3), Dy (4), Sm (5), and Nd (6)] were synthesized by alkyl elimination reaction or by salt metathesis reaction in good yields. All complexes were characterized by elemental analyses, FT-IR spectroscopy and single crystal X-ray diffraction. In combination with [Ph3C][B(C6F5)4] and alkylaluminium, these complexes displayed a good activity towards isoprene polymerization to give polyisoprenes with high molecular weight (M(n) > 10(4)) and narrow molecular distribution (PDI < 2.

Synthesis, structure, and catalytic activity of novel trinuclear rare-earth metal amido complexes incorporating μ-η5:η1 bonding indolyl and μ3-oxo groups.

The reactions of different pyrrolyl-functionalized indoles with rare-earth metal(III) amides [(Me3Si)2N]3RE(III)(μ-Cl)Li(THF)3 (RE = Yb, Er, Dy, Eu, Y) produced different kinds of rare-earth metal amido complexes. Reactions of N-((1H-pyrrol-2-yl)methylene)-2-(1H-indol-3-yl)ethanamine with rare-earth metal amides [(Me3Si)2N]3RE(III)(μ-Cl)Li(THF)3 (RE = Yb, Er, Dy, Eu, Y) in toluene or THF at temperatures of 75-80 °C afforded the novel trinuclear rare-earth metal amido complexes incorporating the indolyl ligand in μ-η(5):η(1) bonding modes and a μ3-O group, which is believed to originate from cleavage of the THF ring based on experimental results. Reactions of 2-(1H-indol-3-yl)-N-((1-methyl-1H-pyrrol-2-yl)methylene)ethanamine with rare-earth metal(III) amides [(Me3Si)2N]3RE(III)(μ-Cl)Li(THF)3 (RE = Yb, Dy) produced mononuclear ytterbium and dysprosium amides having the indolyl ligand in an η(1) bonding fashion.

Synthesis, structure, and reactivity of lanthanide complexes incorporating indolyl ligands in novel hapticities.

The chemistry of interactions of 2-(2,6-diisopropylphenylaminomethylene)indole ligand (1) with europium and ytterbium amides is described. Reaction of 2-(2,6-diisopropylphenylaminomethylene)indole 2-(2,6-i-Pr2C6H3NHCH2)C8H5NH (1) with europium amide [(Me3Si)2N]3Eu(III)(μ-Cl)Li(THF)3 afforded a novel europium(II) complex formulated as {[μ-η(6):η(1):η(1)-2-(2,6-i-Pr2C6H3N═CH)C8H5N]Eu[2-(2,6-i-Pr2C6H3N═CH)C8H5N]}2 (2), having a bridged indolyl ligand in the novel μ-η(6):η(1):η(1) hapticities with the reduction of europium(III) to europium(II) and the oxidation of amino to imino group. Reaction of 2-(2,6-diisopropylphenylaminomethylene)indole 2-(2,6-i-Pr2C6H3NHCH2)C8H5NH (1) with ytterbium(III) amide [(Me3Si)2N]3Yb(III)(μ-Cl)Li(THF)3 produced the only deprotonated ytterbium(III) complex formulated as [2-(2,6-i-Pr2C6H3NCH2)C8H5N]Yb[N(SiMe3)2](THF)2 (3), having an η(1) hapticity indolyl ligand.