Resibufogenin inhibited colorectal cancer cell growth and tumorigenesis through triggering ferroptosis and ROS production mediated by GPX4 inactivation.

Resibufogenin (RB) has been used for cancer treatment, but the underlying mechanisms are still unclear. This study aimed to investigate the effects of RB treatment on colorectal cancer (CRC) cells, and to determine the underlying mechanisms. The cell counting kit-8 assay was used to determine cell viability.

[Quality variation of wheat planted in different regions of Tibet and Beijing].

In order to supply experimental basis for developing high quality and special use wheat for Tibet, multi-varieties experiments in different regions were carried out to study the quality variation of wheat varieties during 1998 to 2001. Field trials of sowing in spring and in autumn were conducted in Linzhi, Rikaze, Lasa and Beijing, and 5 indices including grain protein content, wet gluten content, sedimentation value, falling number and grain hardness were determined. The results showed that the quality characters were significantly different among the varieties, and extremely significant among the sites of same variety.

[Effects of growing process and climatic conditions on grain quality of spring-sown wheat].

In the period of 1998-2000, 10 wheat varieties were used to study the effects of growth, development process and climatic conditions on the quality of wheat grains through spring sowing experiments in Beijing. The results showed that there were no significant variations on the quality traits among the varieties while there were significant variations among different years. The most significant negative correlation had been shown between the days from sowing to ripening and hardness of the grains and between the days from heading to ripening and the content of wet gluten of the grains.