Generation of an induced pluripotent stem cell line (ZSPHARi002-A) from a patient with autosomal dominant polycystic kidney disease carrying a heterozygous PKD1 mutation.

Autosomal dominant polycystic kidney disease (ADPKD), a single-gene-inherited kidney disease, is a common cause of end-stage kidney disease (ESKD). The PKD1 gene mutation is the most common cause of ADPKD, accounting for approximately 78% of cases. ADPKD is characterized by the scattered distribution of multiple cysts in the renal parenchyma, ultimately leading to ESKD.

Enabling High-Performance Multi-Resonant TADF Emitters via Intramolecular Hydrogen Bond.

Hydrogen bonds (HBs), prevalent strong interactions in organic compounds, can effectively constrain single bond rotation, leading to rigid planar configurations. This rigidity enhances emission efficiency and narrows the emission spectrum of luminescent materials. Recent advances have leveraged HBs to advance high-performance donor-acceptor thermally activated delayed fluorescence (TADF) materials.

Atomically dispersed cobalt activator with nitrogen and sulfur co-coordination for high-efficiency Fenton-like catalysis: Insights into density-dependent activity and mechanisms.

Atomically dispersed metal activators (ADMAs) have demonstrated unique advantages in environmental remediation, but how to controllably regulate the active site density and electronic structure of ADMAs to further enhance activation efficiency remains challenging. Here, we introduce a sulfur-atom-doping approach that allows the fine-tuning of atomic Co site content and electronic structure, enabling exploration of density-dependent activation performance of ADMAs for peroxymonosulfate (PMS)-based Fenton-like catalysis. Our investigation reveals a direct correlation between activation capacity and single-Co-site density.

Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy inhibiting tumor-associated macrophage M2 polarization.

Tumor-associated macrophages (TAMs), one of the dominating constituents of tumor microenvironment, are important contributors to cancer progression and treatment resistance. Therefore, regulation of TAMs polarization from M2 phenotype towards M1 phenotype has emerged as a new strategy for tumor immunotherapy. Herein, we successfully initiated antitumor immunotherapy by inhibiting TAMs M2 polarization autophagy intervention with polyethylene glycol-conjugated gold nanoparticles (PEG-AuNPs).

Generation of the induced pluripotent stem cell line (ZSPHARi001-A) from a patient with recessive dystrophic epidermolysis bullosa carrying compound heterozygous mutation in the COL7A1 gene.

The COL7A1 gene mutation causes type VII collagen dysfunction, which subsequently leads to recessive dystrophic epidermolysis bullosa (RDEB). Patients who suffer from RDEB experience severe blisters and chronic trauma, which can eventually result in serious infection and the development of fatal squamous cell carcinoma. In our study, peripheral blood mononuclear cells (PBMCs) from an RDEB patient with the COL7A1 compound heterozygous mutation were collected and then reprogrammed into induced pluripotent stem cells (iPSC).

Tumor RNA-loaded nanoliposomes increases the anti-tumor immune response in colorectal cancer.

Purpose: Tumor RNA vaccines can activate dendritic cells to generate systemic anti-tumor immune response. However, due to easily degraded of RNA, direct RNA vaccine is less effective. In this study, we optimized the method for preparing PEGylated liposom-polycationic DNA complex (LPD) nanoliposomes, increased encapsulate amount of total RNA derived from CT-26 colorectal cancer cells.

Dual-triggered biomimetic vehicles enable treatment of glioblastoma through a cancer stem cell therapeutic strategy.

Glioma stem cells (GSCs) and their complex microenvironment play a crucial role in the high invasion of cancer and therapeutic resistance and are considered to be the most likely cause of cancer relapse. We constructed a biomimetic vehicle (LDL-SAL-Ang) based on a low density lipoprotein triggered by Angiopep-2 peptide and ApoB protein, to improve the transport of an anti-GSC therapeutic agent into the brain. The LDL-SAL-Ang showed significant inhabitation for GSC microsphere formation and induced the highest apoptotic rate in two types of GSCs.

Correction: Rapid room temperature synthesis of red iridium(iii) complexes containing a four-membered Ir-S-C-S chelating ring for highly efficient OLEDs with EQE over 30.

[This corrects the article DOI: 10.1039/C8SC05605F.].

Pure Red Iridium(III) Complexes Possessing Good Electron Mobility with 1,5-Naphthyridin-4-ol Derivatives for High-Performance OLEDs with an EQE over 31.

Three iridium(III) complexes (Ir(4tfmpq)mND, Ir(4tfmpq)mmND, and Ir(4tfmpq)mpND) with the 4-(4-(trifluoromethyl)phenyl)quinazoline (4tfmpq) main ligand and 1,5-naphthyridin-4-ol derivatives (mND: 8-methyl-1,5-naphthyridin-4-ol, mmND: 2,8-dimethyl-1,5-naphthyridin-4-ol, mpND: 8-methyl-2-phenyl-1,5-naphthyridin-4-ol) as ancillary ligands were studied. The complexes (Ir(4tfmpq)mND, Ir(4tfmpq)mmND, and Ir(4tfmpq)mpND) emit pure red emissions of 626-630 nm with high photoluminescence quantum yields of 85.2-93.

Rapid room temperature synthesis of red iridium(iii) complexes containing a four-membered Ir-S-C-S chelating ring for highly efficient OLEDs with EQE over 30.

Three red cyclometalated iridium(iii) complexes (4tfmpq)Ir(dipdtc), (4tfmpq)Ir(dpdtc) and (4tfmpq)Ir(Czdtc) (4tfmpq = 4-(4-(trifluoromethyl)phenyl)quinazoline, dipdtc = ,-diisopropyl dithiocarbamate, dpdtc = ,-diphenyl dithiocarbamate, and Czdtc = -carbazolyl dithiocarbamate) containing the unique four-membered Ir-S-C-S backbone ring were synthesized in five minutes at room temperature with good yields, and the Gibbs free energy calculation results indicate that all reactions are exothermic and thermodynamically favorable processes. The emission colors ( = 641-611 nm), photoluminescence quantum efficiencies ( = 58.3-93.

NIR-Responsive Copolymer Upconversion Nanocomposites for Triggered Drug Release in Vitro and in Vivo.

Light has several advantages as the stimulus for a triggered drug release. Currently, the applications of phototriggered drug-release devices (PDDs) are largely limited by two factors: the limited tissue penetration and detrimental effects caused by excitation light (ultraviolet or visible light). To address this disadvantage, this study developed nanocomposites based on upconversion nanoparticles (UC), which could convert near-infrared light to ultraviolet-visible light and trigger drug release.

Two platinum(ii) complexes with a 4-phenyl-4H-1,2,4-triazole derivative as an ancillary ligand for efficient green OLEDs.

Two new cyclometalated platinum(ii) complexes ((TNT)Pt(dptp), (4tfmppy)Pt(dptp)) with 2',6'-bis(trifluoromethyl)-2,3'-bipyridine (TNT) and 4-trifluoromethylphenylpyridine (4tfmppy) as the cyclometalated ligands and the nitrogen heterocycle 2-(4,5-diphenyl-4H-1,2,4-triazol-3-yl)phenol (dptp) as the ancillary ligand were developed. Both complexes are green phosphors with high photoluminescence quantum efficiency yields (λ = 532 nm, Φ = 65% for (TNT)Pt(dptp) and λ = 502 nm, Φ = 71% for (4tfmppy)Pt(dptp)) in CHCl solutions at room temperature, respectively. Organic light-emitting diodes (OLEDs) with single-emitting layer and double-emitting layer structures were fabricated with good performances.

Efficient orange-red electroluminescence of iridium complexes with 1-(2,6-bis(trifluoromethyl)pyridin-4-yl)isoquinoline and 4-(2,6-bis(trifluoromethyl)pyridin-4-yl)quinazoline ligands.

Two novel iridium(iii) complexes, Ir(tfmpiq)(acac) (tfmpiq = 1-(2,6-bis(trifluoromethyl)pyridin-4-yl)isoquinoline, acac = acetylacetone) and Ir(tfmpqz)(acac) (tfmpqz = 4-(2,6-bis(trifluoromethyl)pyridin-4-yl)quinazoline), were synthesized and thoroughly investigated. Both complexes emit orange-red photoluminescence with high quantum yields (Ir(tfmpiq)(acac): λ: 587 nm, η: 42%; Ir(tfmpqz)(acac): λ: 588 nm, η: 91%). Furthermore, the complex containing quinazoline shows higher electron mobility than that with isoquinoline.

Novel Design of Iridium Phosphors with Pyridinylphosphinate Ligands for High-Efficiency Blue Organic Light-emitting Diodes.

Due to the high quantum efficiency and wide scope of emission colors, iridium (Ir) (III) complexes have been widely applied as guest materials for OLEDs (organic light-emitting diodes). Contrary to well-developed Ir(III)-based red and green phosphorescent complexes, the efficient blue emitters are rare reported. Like the development of the LED, the absence of efficient and stable blue materials hinders the widely practical application of the OLEDs.

Syntheses, photoluminescence and electroluminescence of two novel platinum(ii) complexes.

Two new platinum(ii) cyclometalated complexes with 2-(4-trifluoromethyl)phenylpyridine (4-tfmppy) as the main ligand and tetraphenylimidodiphosphinate (tpip) (Pt-tpip) and tetra(4-fluorophenyl)imidodiphosphinate (ftpip) (Pt-ftpip) as ancillary ligands were developed. Both complexes were green phosphors with photoluminescence quantum efficiency yields of 71.5% and 79.

N-Heterocyclic carbenes: versatile second cyclometalated ligands for neutral iridium(III) heteroleptic complexes.

With 2-(2,4-difluorophenyl)pyridine (dfppy) as the first cyclometalated ligand and different monoanionic N-heterocyclic carbenes (NHCs) as the second cyclometalated ligands, 16 blue or greenish-blue neutral iridium(III) phosphorescent complexes, (dfppy)2Ir(NHC), were synthesized efficiently. The obtained Ir(III) complexes display typical phosphorescence of 455-485 nm with quantum yields up to 0.73.

Survey of heavy metal pollution in four chinese crude drugs and their cultivated soils.

A two-year survey on the residues of heavy metals in four Chinese crude drugs and their cultivated soils was conducted. Targeted heavy metals were copper (Cu), arsenic (As), lead (Pb), nickel (Ni), and cadmium (Cd). Herbs surveyed include White Peony Root (Radix Paeoniae Alba), Turmeric Root Tuber (Radix Curcumae), Thunberg Fritillary Bulb (Bulbus Fritillariae Thumbergii), and Tuber of Dwarf Lilyturf (Radix Ophiopogonis).