Phillygenin attenuates cell apoptosis and microglia activation in cerebral ischaemia-reperfusion rats through activation of peroxisome proliferator-activated receptor γ.

Ischaemic stroke is a common condition that can lead to cerebral ischaemia-reperfusion injury. Phillygenin (PHI), a natural bioactive compound derived from Forsythia suspensa, has been shown to play a crucial role in regulating inflammation across various diseases. However, its specific regulatory effects in ischaemic stroke progression remain unclear.

Degradation and mechanism analysis of protein macromolecules by functional bacteria in tobacco leaves.

Tobacco, a crop of significant economic importance, was greatly influenced in leaf quality by protein content. However, current processing parameters fail to adequately meet the requirements for protein degradation. Microorganisms possess potential advantages for degrading proteins and enhancing the quality of tobacco leaves, and hold substantial potential in the process of curing.

Pyroptosis in Spinal Cord Injury: Implications for Pathogenesis and Therapeutic Approaches.

Traumatic spinal cord injury (SCI) is a serious disease of the central nervous system. Aside from the limited intrinsic regenerative capacity of neurons, complex microenvironmental disturbances can also lead to further cellular damage and growth inhibition. Programmed cell death regulated by pyroptosis has an important role in the pathogenesis of SCI.

Fabrication of N and S co-doped lignin-based porous carbon aerogels loaded with FeCo alloys and their application to oxygen evolution and reduction reactions in Zn-air batteries.

Zn-air batteries are a highly promising clean energy sustainable conversion technology, and the design of dual-function electrocatalysts with excellent activity and stability is crucial for their development. In this work, FeCo alloy loaded biomass-based N and S co-doped carbon aerogels (FeCo@NS-LCA) were fabricated from chitosan and lignosulfonate-metal chelates via liquid nitrogen pre-frozen synergistic high-temperature carbonization with application in electrocatalytic reactions. The abundant oxygen-containing functional groups on lignosulfonates have a chelating effect on metal ions, which can avoid the aggregation of metal nanoparticles during carbonation and catalysis, facilitating the construction of a nanoconfinement catalytic system with biomass carbon as the domain-limiting body and FeCo nanoparticles as the active sites.

Screening, identification, and mechanism analysis of starch-degrading bacteria during curing process in tobacco leaf.

Tobacco, a vital economic crop, had its quality post-curing significantly influenced by starch content. Nonetheless, the existing process parameters during curing were inadequate to satisfy the starch degradation requirements. Microorganisms exhibit inherent advantages in starch degradation, offering significant potential in the tobacco curing process.

Peroxymonosulfate activation by walnut shell activated carbon supported nano zero-valent iron for the degradation of tetracycline: Performance, degradation pathway and mechanism.

In this study, activated carbon (WS-AC) was prepared from walnut shell. Nano-zero-valent iron (nZVI) was loaded on walnut shell activated carbon by liquid phase reduction method and used as catalyst (WS-AC/nZVI) to activate peroxymonosulfate (PMS) to efficiently degrade tetracycline (TC) in solution. The composite material with a mass ratio of WS-AC to nZVI of 1:1 has the highest catalytic performance for activating PMS to degrade TC.

A lignin-derived N-doped carbon-supported iron-based nanocomposite as high-efficiency oxygen reduction reaction electrocatalyst.

Fuel cells are a promising renewable energy technology that depend heavily on noble metal Pt-based catalysts, particularly for the oxygen reduction reaction (ORR). The discovery of new, efficient non-precious metal ORR catalysts is critical for the continued development of cost-effective, high-performance fuel cells. The synthesized carbon material showed excellent electrocatalytic activity for the ORR, with half-wave potential (E) and limiting current density (JL) of 0.

Synergistic effects of hierarchical porous structures and ultra-high pyridine nitrogen doping enhance the oxygen reduction reaction electrocatalytic performance of metal-free laminated lignin-based carbon.

Construction of non-metallic biomass-carbon based catalysts for fuel cell air cathode applications has attracted great attention in recent years. In this work, a convenient and clean technique was developed to fabrication nitrogen-doped lignin-based hierarchical porous lamellar carbon (N-LHPC) via lignin as the carbon precursor, melamine/urea as the nitrogen source and ZnCO.2HO as the chemical activator.

Ferroptosis: a new regulatory mechanism in neuropathic pain.

Neuropathic pain (NP) is pain caused by damage to the somatosensory system. It is a common progressive neurodegenerative disease that usually presents with clinical features such as spontaneous pain, touch-evoked pain, nociceptive hyperalgesia, and sensory abnormalities. Due to the complexity of the mechanism, NP often persists.

Continuous-Flow Microreactor Accelerates Molecular Collisions for Lignin Depolymerization to Phenolic Monomers and Oligomers.

Effective depolymerization of lignin is the most important step for its comprehensive utilization. So far, most of the studies on depolymerization of lignin focused on batch processing, whereas only a few studies relied on the microreactor. In this study, we developed a continuous-flow microreactor for depolymerization of lignin into monomeric and oligomeric compounds.

Stress/cell death pathways, neuroinflammation, and neuropathic pain.

Neuropathic pain is a common and debilitating modality of chronic pain induced by a lesion or disease of the somatosensory nervous system. Albeit the elucidation of numerous pathophysiological mechanisms and the development of potential treatment compounds, safe and reliable therapies of neuropathic pain remain poor. Multiple stress/cell death pathways have been shown to be implicated in neuroinflammation during neuropathic pain.

A meta-analysis comparing the effects of cemented and uncemented prostheses on wound infection and pain in patients with femoral neck fractures.

To providing evidence-based recommendations for surgery in patients with femoral neck fractures, a meta-analysis was conducted to comprehensively evaluate the effects of cemented and uncemented prostheses on postoperative surgical site wound infection and pain in these patients. Relevant studies on the use of cemented prostheses in femoral neck fractures were retrieved from PubMed, EMBASE, Cochrane Library, Ovid, CNKI, and Wanfang databases from the time of their establishment until March 2023. Two authors independently screened and extracted data from the included and excluded literature according to predetermined criteria.

Lignin-derived sulfonate base metal-free N, S co-doped carbon microspheres doped with different nitrogen sources as catalysts for oxygen reduction reactions.

The oxygen reduction reaction (ORR) is an important step in the widespread application of metal-air batteries, so it is necessary to study and develop low-cost and efficient metal-free carbon-based catalysts to catalyze the ORR reaction. Heteroatomic doping, especially N and S co-doped carbon materials, has received much focus as a promising ORR catalyst. Meanwhile, the lignin material has high carbon content, wide source, and low price, and has wide application prospects for the preparation of carbon material catalysts.

Comprehensive analysis of a pyroptosis-related gene signature of clinical and biological values in spinal cord injury.

Background: Since some of the clinical examinations are not suitable for patients with severe spinal cord injury (SCI), blood biomarkers have been reported to reflect the severity of SCI. The objective of this study was to screen out the potential biomarkers associated with the diagnosis of SCI by bioinformatics analysis.

Methods: The microarray expression profiles of SCI were obtained from the Gene Expression Omnibus (GEO) database.

Treating Osteoporotic Spinal Fractures in Elderly Patients via a Modified Clinical Bone Cement Injection Technique.

The minimally invasive injection of bone cement (MIIBC) is an effective way to treat senile osteoporotic spinal fractures (OSF) in clinical practice. However, the intraspinal dura and nerves may be damaged when the puncture needle passes through the pedicle. Therefore, in this protocol, the puncture site was optimized during the surgery, selecting the same 1-2 cm away from the surface projection of the diseased vertebra.

Broad-spectrum portable magnetic relaxation switching immunosensor with gold-functionalized magnetic nanoprobes for the sensitive detection of multiple pyrethroids.

At present, the most available pyrethroid (PYR) detection methods still suffer from a narrow detection spectrum, low sensitivity, and less portability. Herein, a novel magnetic relaxation switching (MRS) sensor was elaboratively designed to detect multiple PYRs, combining a novel broad-spectrum antibody CL-CN/1D2 and synthesized immune gold-functionalized magnetic nanoparticles, with the inherent response of the sensor. A series of antibodies and the immune gold-functionalized magnetic nanoparticles were designed and synthesized.

Chinese Pedigree with Hereditary Gastrointestinal Stromal Tumors: A Case Report and Literature Review.

Familial gastrointestinal stromal tumor (GIST) is a rare autosomal dominant genetic disorder with only a few affected families reported to date. Here, we report a case of familial GISTs harboring a novel germline mutation within exon 18 of . A 58-year-old male patient presented with gastric subepithelial lesions accompanied by cutaneous hyperpigmentation, which were subsequently diagnosed as multinodular GISTs.

Lignin-based nitrogen/sulfur dual-doped nanosheets decorated with CoS nanoparticles as efficient bifunctional oxygen electrocatalysts.

The development of efficient, cost-effective, bifunctional cathode catalyst materials to replace precious metals is highly attractive for the fabrication of Zn-air battery. Here, the three-dimensional N and S co-doped carbon nanosheets loaded with cobalt sulfide nanoparticles (CoS@SNFC) for bifunctional oxygen electrocatalysis were synthesized with Co(NO)·6HO as the Co source, lignin as the carbon source, thiourea as the nitrogen/ sulfur source, and MgO as the template. The synergistic effect of multiple active sites gives the CoS@SNFC fast electrochemical kinetic properties and excellent stability to oxygen reduction reactions (ORR) and oxygen evolution reactions (OER).

Honokiol Reduces Mitochondrial Dysfunction and Inhibits Apoptosis of Nerve Cells in Rats with Traumatic Brain Injury by Activating the Mitochondrial Unfolded Protein Response.

This study was designed to determine the effects and underlying mechanism of honokiol (HNK) on traumatic brain injury (TBI). A rat TBI model was constructed using the modified Feeney free-fall percussion method and treatment with HNK via intraperitoneal injection. The brain tissues of the rats in each group were assessed using the terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay to detect the level of neuronal apoptosis.

Role of Glucagon and Its Receptor in the Pathogenesis of Diabetes.

Various theories for the hormonal basis of diabetes have been proposed and debated over the past few decades. Insulin insufficiency was previously regarded as the only hormone deficiency directly leading to metabolic disorders associated with diabetes. Although glucagon and its receptor are ignored in this framework, an increasing number of studies have shown that they play essential roles in the development and progression of diabetes.