Real-world effectiveness and safety of oral azvudine versus nirmatrelvir‒ritonavir (Paxlovid) in hospitalized patients with COVID-19: a multicenter, retrospective, cohort study.

Azvudine and nirmatrelvir-ritonavir (Paxlovid) were widely used to treat patients with COVID-19 in China during the Omicron wave. However, the efficacy and safety of azvudine versus Paxlovid are poorly established. This study included 40,876 hospitalized patients with COVID-19 from eleven hospitals in Henan and Xinjiang Provinces, China.

Lanthanide-polyoxometalate-based self-erasing luminescent hydrogels with time-dependent and resilient properties for advanced information encryption.

In such an era of information explosion, improving the level of information security is still a challenging task. Self-erasing luminescent hydrogels are becoming ideal candidates for improving the level of information security with simple encryption and decryption methods. Herein, a lanthanide-polyoxometalate-based self-erasing luminescent hydrogel with time-dependent and resilient properties was constructed through a covalent crosslinked network constructed with polyacrylamide and a non-covalent crosslinked network constructed with [2-(methacryloyloxy)ethyl]trimethyl ammonium chloride/NaDyWO, along with doping urease.

Comparison of the safety and efficacy of ciprofol monotherapy versus combined propofol for painless gastroscopy.

Traditional sedatives like Propofol can lead to adverse effects. This study compares the safety and efficacy of Ciprofol monotherapy versus combined Propofol for painless gastroscopy. Patients underwent painless gastroscopy at our hospital from January 2023 to December 2023 were studied.

Erratum: Regulation of ezrin tension by S-nitrosylation mediates non-small cell lung cancer invasion and metastasis: Erratum.

[This corrects the article DOI: 10.7150/thno.32479.

CD24-Fc resolves inflammation and rescues CD8 T cells with polyfunctionality in humanized mice infected with HIV-1 under cART.

The persistence of HIV-1 reservoirs during combination anti-retroviral therapy (cART) leads to chronic immune activation and systemic inflammation in people with HIV (PWH), associating with a suboptimal immune reconstitution as well as an increased risk of non-AIDS events. This highlights the needs to develop novel therapy for HIV-1 related diseases in PWH. In this study, we assessed the therapeutic effect of CD24-Fc, a fusion protein with anti-inflammatory properties that interacts with danger-associated molecular patterns (DAMPs) and siglec-10, in chronic HIV-1 infection model using humanized mice undergoing suppressive cART.

Seq2Seq-based GRU autoencoder for anomaly detection and failure identification in coal mining hydraulic support systems.

In coal mining operations, the stable operation of hydraulic supports is crucial for ensuring mine safety. However, the nonlinear, non-stationary characteristics and noise interference in hydraulic support pressure data pose significant challenges for anomaly detection and fault diagnosis. This study proposes an anomaly detection and failure identification method based on Gated Recurrent Unit Autoencoder (GRU-AE), aimed at achieving anomaly detection in hydraulic support pressure data and equipment failure early warning.

Chinese expert consensus on sequential surgery following conversion therapy based on combination of immune checkpoint inhibitors and antiangiogenic targeted drugs for advanced hepatocellular carcinoma (2024 edition).

Up to half of hepatocellular carcinoma (HCC) cases are diagnosed at an advanced stage, for which effective treatment options are lacking, resulting in a poor prognosis. Over the past few years, the combination of immune checkpoint inhibitors and anti-angiogenic targeted therapy has proven highly efficacious in treating advanced HCC, significantly extending patients' survival and providing a potential for sequential curative surgery. After sequential curative hepatectomy or liver transplantation following conversion therapy, patients can receive long-term survival benefits.

Chinese guidelines for minimally invasive donor hepatectomy in living donor liver transplantation (2024 edition).

Background: Minimally invasive surgeries are increasingly central to modern medicine, particularly in liver transplantation. These techniques, which offer reduced trauma, precise operations, minimal bleeding, and swift recovery, are, however, unevenly adopted across China. Only a limited number of centers routinely perform minimally invasive donor hepatectomies, indicating a significant imbalance in the development and application of these advanced procedures.

Dual Responsive Magnetic DCR3 Nanoparticles: A New Strategy for Efficiently Targeting Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is a major cause of cancer deaths globally. Unlike traditional molecularly targeted drugs, magnetically controlled drug delivery to micro/nanorobots enhances precision in targeting tumors, improving drug efficiency and minimizing side effects. This study develops a dual-responsive, magnetically controlled drug delivery system using PEGylated paramagnetic nanoparticles conjugated with decoy receptor 3 (DCR3) antibodies.

Real-world effectiveness and safety of azvudine in hospitalized patients with SARS-CoV-2 infection: A multicenter, retrospective cohort study.

Objectives: Azvudine has been designated as a priority treatment for patients infected with SARS-CoV-2, however, clinical evidence in hospitalized cases remains insufficient.

Methods: We performed a multi-center, retrospective cohort study to evaluate the effectiveness and safety of azvudine in hospitalized patients with SARS-CoV-2 in China (NCT06349655). Kaplan-Meier method, Cox regression model, subgroup analysis, and seven sensitive analyses were employed.

Deciphering the composition and key driver genes of breast invasive micropapillary carcinoma by multi-omics analysis.

In this study, we delved into the intrinsic cellular components and transcriptomic signatures characterizing breast-invasive micropapillary carcinoma (IMPC). Employing bulk RNA sequencing, we conducted differential gene expression and functional profiles across breast cancer tissues. Single-cell transcriptome sequencing was performed on mixed IMPC samples.

Zn-Doped Hollow Cubic MnO as a High-Performance Cathode Material for Zn Ion Batteries.

Manganese-based compounds have the characteristics of high theoretical capacity, low cost and stable performance, thus become a research hotspot for cathode materials of zinc-ion batteries (ZIBs). However, in the process of charging and discharging, it is accompanied by problems such as structural collapse and low conductivity, which resulted in severe capacity degration during cycles. In this paper, a kind of Zn doped MnO hollow cube cathode material (Zn-MnO) was prepared by self-sacrificing template method.

Targeting the Intestinal Microbiota: A Novel Direction in the Treatment of Inflammatory Bowel Disease.

Over the past decade, there has been a rapid increase in the incidence of inflammatory bowel disease. It has been suggested that multifactorial interactions of environmental factors, genetic factors, immune response and intestinal microbiota are involved in the pathogenesis of inflammatory bowel disease. It is widely recognized that the intestinal microbiota are essential for human metabolism, the immune system and pathogen resistance, and are integral to human health.

New roles of Lagrange multiplier method in generalizability theory: Inference of estimating the optimal sample size for teaching ability evaluation of college teachers.

Background: Generalizability theory is widely used in psychological and educational measurement. Budget and cost are the problems that cannot be neglected in the measurement. When there is a budget constraint, the generalizability theory needs to consider how to design a measurement program with relatively high reliability and feasibility, which requires the optimal sample size to be estimated by some means.

Expected 8-Week Prenatal vs 12-Week Perinatal Tenofovir Alafenamide Prophylaxis to Prevent Mother-to-Child Transmission of Hepatitis B Virus: A Multicenter, Prospective, Open-Label, Randomized Controlled Trial.

Introduction: The course of maternal antiviral prophylaxis to prevent mother-to-child transmission of hepatitis B virus (HBV-MTCT) varies greatly, and it has not been demonstrated in a randomized controlled study.

Methods: In this multicenter, open-label, randomized controlled trial, eligible pregnant women with HBV DNA of 5.3-9.

Research on wheat impurity identification method based on terahertz imaging technology.

The traditional detection of impurities in wheat has difficulties such as low precision, time-consuming, and cumbersome, therefore, it is important to study the method of rapid and accurate detection of impurities in wheat for correctly assessing the quality grade of wheat. Terahertz (THz) technology has many superior properties such as transient, broadband, low-energy, and penetrating, which can realize rapid and nondestructive detection of wheat quality. In this study, a classification and recognition algorithm AHA-RetinaNet-X for wheat impurity terahertz images based on RetinaNet and Artificial hummingbird algorithm (AHA) is proposed.

Efficacy of CalliSpheres drug-loaded microspheres combined with doxorubicin in hepatocellular carcinoma.

Objective: This study compared the efficacy and safety of the transarterial chemoembolization with CalliSpheres drug-eluting beads loading with doxorubicin (DEB-TACE) versus conventional lipiodol (cTACE) in patients with unresectable hepatocellular carcinoma (HCC).

Methods: A randomized controlled trial (RCT) was conducted with 144 patients, who were randomly assigned to receive either DEB-TACE with doxorubicin-loaded CalliSpheres microspheres or cTACE with doxorubicin-lipiodol emulsion. Patients were followed up for 12 months, with assessments at 3 and 12 months posttreatment.

Blood trihalomethane and urinary haloacetic acid concentrations in relation to hypertension: An observational study among 1162 healthy men.

Disinfection byproducts (DBPs) have demonstrated cardiovascular and reproductive toxicity. However, the associations and mechanisms of DBP exposure in relation to hypertension among healthy young men, which are critical for gaining new insights into the prevention and treatment of male subfertility, remain unclear. In 2017-2018, we recruited 1162 healthy Chinese men.

Self-assembly of Dawson-type HPWO@[CuO(TZI)(HO)] for high-performance aerobic oxidation desulfurization of fuel.

Because global sulfur emission has escalated, the development of high-efficiency deep desulfurization techniques has become imperative. Herein, to design a high-activity heterogeneous catalyst for the aerobic oxidation desulfurization (AODS) of fuel, Dawson-type polyoxometalate (HPWO abbreviated as D-PW), characterized by its high activity and strong oxidative capacity, was applied to react with CuCl·2HO and HTZI a one-pot hydrothermal method. Consequently, blue crystalline HPWO[CuO(TZI)(HO)] (abbreviated as D-PW@-MOF-1; -MOF-1 = [CuO(TZI)(HO)]·HO) was afforded.

Sediment subduction in Hadean revealed by machine learning.

Due to the scarcity of rock samples, the Hadean Era predating 4 billion years ago (Ga) poses challenges in understanding geological processes like subaerial weathering and plate tectonics that are critical for the evolution of life. The Jack Hills zircon from Western Australia, the primary Hadean samples available, offer valuable insights into magma sources and tectonic genesis through trace element signatures. However, a consensus on these signatures has not been reached.