A novel collision tumour of myofibroblastoma and low-grade adenosquamous carcinoma in breast.

Background: Myofibroblastoma (MFB) and low-grade adenosquamous carcinoma (LGASC) are rare tumours in the breast, respectively. However, a collision tumour of the two types has never been reported.

Case Presentation: A 42-year-old female presented with a palpable mass in diameter of about 2.

Risk factors associated with histological upgrade of gastric low-grade dysplasia on pretreatment biopsy.

Objectives: Histological discrepancies between biopsy and resection specimens are common. In this study, we aimed to analyze the risk factors predicting histological upgrade or downgrade of biopsy-diagnosed gastric low-grade dysplasia (LGD).

Methods: The medical records of patients with 104 biopsy-diagnosed gastric LGD from January 2011 to December 2017 were collected.

Granular Cell Tumor of the Neurohypophysis With TFE-3 Expression: A Rare Case Report.

Granular cell tumor (GCT) rarely involves the central nervous system, and fewer than 100 cases have been reported in English literatures. We herein report a case of a 36-year-old Chinese man with GCT of the neurohypophysis. Magnetic resonance imaging showed one mass located in the hypophysis with heterogeneous contrast enhancement.

Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning.

Unlabelled: Nanoscale drug depots, comprising a drug reservoir surrounded by a carrier membrane, are much sought after in contemporary pharmaceutical research. Using cellulose acetate (CA) as a filament-forming polymeric matrix and ferulic acid (FA) as a model drug, nanoscale drug depots in the form of core-shell fibers were designed and fabricated using a modified tri-axial electrospinning process. This employed a solvent mixture as the outer working fluid, as a result of which a robust and continuous preparation process could be achieved.

Influence of Working Temperature on The Formation of Electrospun Polymer Nanofibers.

Temperature is an important parameter during electrospinning, and virtually, all solution electrospinning processes are conducted at ambient temperature. Nanofiber diameters presumably decrease with the elevation of working fluid temperature. The present study investigated the influence of temperature variations on the formation of polymeric nanofibers during single-fluid electrospinning.

Disseminated intracranial xanthoma disseminatum: a rare case report and review of literature.

Background: Xanthoma disseminatum (XD) is a rare benign histiocytic proliferating disease of non-Langerhans cell origin, which is clinically mainly characterized by cutaneous or mucous lesions. Although XD is acknowledged of one systematic disease, involvement of the central nervous system is quite rare.

Case Presentation: We presented one 34-year-old Chinese female with disseminated intracranial XD without cutaneous or oral mucosal papules and masses of the other organs.

[Clinicopathologic features of collagenous spherulosis of the breast].

Objective: To investigate the morphological features, immunohistochemical phenotype, diagnosis and differential diagnosis of collagenous spherulosis of the breast.

Methods: Clinicopathologic observation, immunohistochemistry using EnVision method and histochemical staining were applied in 33 cases of collagenous spherulosis of the breast.

Results: Collagenous spherulosis of the breast was a benign lesion, consisting of proliferative myoepithelial and ductal epithelial cells.

[Invasive lobular carcinoma of basal-like subtype of breast: a clinicopathologic analysis].

Objective: To investigate the clinicopathologic features, clinical progress and prognosis of the basal-like subtype of invasive lobular carcinoma (ILC) of the breast.

Methods: Four cases of ILC were analyzed by detailed histopathologic observation and immunohistochemical staining for E-cadherin, p120 catenin, ER, PR, HER2, CK5/6, EGFR, p63, p53, Ki-67 using MaxVision method. The follow-up and clinical data were analyzed.

Giant mesenteric hemangioma of cavernous and venous mixed type: a rare case report.

Background: Although vascular tumours are one of the most common soft tissue neoplasms, those occurring in the gastrointestinal system are rare and cases involving mesentery are even further rare. Herein, we reported a rare case of giant hemangioma in mesentery of the small bowel.

Case Presentation: A 5-year-old girl was admitted to the emergency room with abdominal pain and vomit for two days.

[Morphologic evaluation of papillary carcinoma of the breast featuring expansile invasion].

Objective: To study the pathology, diagnosis and differential diagnosis of papillary carcinoma of the breast featuring expansile invasion.

Methods: Morphologic analysis and immunohistochemical study using MaxVision method were carried out in 25 cases of papillary carcinoma of the breast featuring expansile type of invasion.

Results: All the 25 cases were female, and ranged from 26 to 84 years old in age with median of 69.

[Morphology, immunohistochemistry and hTERC gene in-situ hybridization in Barrett's esophagus].

Objective: To study the clinicopathologic features and differential diagnosis of proximal gastric mucosa and mucosa of Barrett's esophagus (BE) in biopsy specimens.

Method: Thirty-eight cases of Barrett's esophagus (diagnosed using WHO criteria) and 44 cases of proximal gastric mucosa were studied by immunohistochemistry (for CK7, CK20, CK4, CK8, S-100 protein, MUC6, COX2 and bcl-2) and fluorescence in-situ hybridization (FISH) (for hTERC gene). The pathologic features were analyzed.

Is mammary not otherwise specified-type sarcoma with CD10 expression a distinct entity? A rare case report with immunohistochemical and ultrastructural study.

Unlabelled: Mammary sarcoma is extremely rare and the diagnosis is established only after metaplastic carcinomas and malignant phyllodes tumours are excluded. A rare case of not otherwise specified-type sarcoma with CD10 expression in the left breast in a 45-year-old female was presented. It was a high-grade tumour composed of spindle cells histologically.

Hyalinizing trabecular tumor of the thyroid: Case report and review of the literature.

In 1987, Carney et al described a rare thyroid tumor termed hyalinizing trabecular adenoma presenting characteristics consisting of a trabecular growth pattern and hyalinizing stroma. In subsequent reports, the observed nuclear features and RET alterations led this tumor to be linked to papillary carcinoma. Subsequent reports concerning hyalinizing trabecular carcinoma further complicated its classification.

Osteopontin is overexpressed in colorectal carcinoma and is correlated with P53 by immunohistochemistry.

Osteopontin (OPN), a secreted phosphorylated glycoprotein, has been found to be involved in carcinogenesis, progression and metastasis of several types of cancers. The aim of the present study was to investigate the immunohistochemical expression of OPN in colorectal carcinoma (CRC) and its relationship with clinicopathological parameters and P53. Expression of OPN, Ki-67 and TP53 was detected in 77 cases of CRC by immunohistochemistry and the correlation of the expression of OPN with clinicopathological features, Ki-67 and P53 staining was investigated.

[Pathologic diagnosis and differential diagnosis of low-grade adenosquamous carcinoma of breast and syringomatous adenoma of nipple].

Objective: To investigate the pathologic and immunohistochemical features, diagnosis and differential diagnosis of low-grade adenosquamous carcinoma of the breast and syringomatous adenoma of the nipple.

Methods: Six cases of low-grade adenosquamous carcinoma of the breast and four cases of syringomatous adenoma of the nipple were examined histologically and immunohistochemically (MaxVision method), and the literature was reviewed.

Results: The two types of tumors were similar in morphology, but located in different regions with low-grade adenosquamous carcinoma being present in the deep parenchyma and syringomatous adenoma in nipple.

[Expression of E-cadherin, p120catenin and 34βE12 in invasive lobular carcinoma of breast and their roles in diagnosis].

Objective: To investigate expressions of E-cadherin (E-cad), p120catenin (p120), 34βE12 in invasive lobular carcinomas of the breast and their roles of diagnoses.

Methods: The 81 cases of ILC, including 67 cases of pure type and 14 cases of ductal-lobular mixed type, which had been diagnosed in our department were collected and immunohistochemistry of E-cad, p120 and 34βE12 were performed. All the cases were diagnosed again according to morphology and immunophenotypes (MaxVision method), and difference of diagnoses and expressions of the three indexes were analysed.

[Pathological study of radial sclerosing lesions].

Objective: To investigate the pathological diagnostic features and the differential diagnosis of radial sclerosing lesions of the breast.

Methods: Morphological observation and immunohistochemistry were applied to forty-four cases of radial sclerosing lesions of the breast.

Results: All forty-four patients were females, the mean age was 40.

[Nipple adenoma: report of 18 cases with review of literatures].

Objective: To investigate the clinicopathological and immunohistochemical features, diagnosis and differential diagnosis of nipple adenoma of the breast.

Methods: Morphological observation and immunohistochemistry were applied to 18 cases of nipple adenoma with a review of the related literatures.

Results: The neoplasms were localized at nipples or under the areola of breast, adherent to the epidermis, mainly composed of dilated ducts in a tubular appearance associated with fibrotic matrix.

[Clinicopathological and immunohistochemical features of colorectal sessile serrated adenoma].

Objective: To investigate the clinicopathological characteristics and expression status of Ki67, p53, CEA, CDX, CK7 in colorectal sessile serrated adenoma (SSA).

Methods: The clinicopathological data of 11 cases of SSA, 51 cases of hyperplastic polyp (HP) and one case with mixed HP/SSA were reviewed and analyzed retrospectively. The expression of Ki67, p53, CEA, CDX and CK7 were detected by immunohistochemistry.

[Clinicopathologic features and proliferative status of colorectal serrated lesions: a study of 104 cases].

Objective: To study the clinicopathologic features and proliferative status of colorectal hyperplastic polyp (HP), sessile serrated adenoma (SSA) and traditional serrated adenoma (TSA).

Methods: One hundred and four cases colorectal serrated lesions were collected from 2628 cases of colorectal polyps during the period from November, 2002 to December, 2007. The clinicopathologic features and expression of proliferation marker Ki-67 were studied.

Localized malignant myxoid anaplastic mesothelioma of the pericardium.

Unlabelled: Primary malignant mesothelioma of the pericardium is a rare cardiac neoplasm. Most are diffuse and have poor prognosis with median survival of six months. In the paper, we describe a young male patient having no exposure history of asbestos with localized malignant myxoid mesothelioma of the pericardium.