Publications by authors named "Guang-yun Xie"
[Changes of pathologic feature and microtubulin associated protein 2 in nervous system of hens with organophosphate-induced delayed neuropathy induced by 2,4,6-trimethylbenzoyl phenylphosphonate].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
January 2010
Objective: To develop the organophosphate-induced delayed neuropathy (OPIDN) hen model with 2,4,6-trimethylbenzoyl phenylphosphonate (TOCP), and observe the change of pathology and investigate the alterations of microtubulin associated protein 2 (MAP2).
Methods: 48 adult hens were randomly divided into four groups, including three experimental groups and control group (n = 12 each group). The hens in three experimental groups were treated with TOCP by gavage at single dosages of 250, 500 and 750 mg/kg respectively while the control hens received an equivalent volume of corn oil by gavage.
[Study on malignant transformation of human bronchial epithelial cells induced by glycidyl methacrylate].
Zhonghua Yu Fang Yi Xue Za Zhi
March 2009
Article Synopsis
- The study aimed to investigate how glycidyl methacrylate (GMA) can cause malignant changes in human bronchial epithelial cells (16HBE).
- Experiments showed that treatment with GMA led to an increase in transformed cell growth and capability, notably at higher concentrations (especially 8 microg/ml), with significant differences compared to control groups.
- The transformed cells displayed characteristics of malignancy, like loss of contact inhibition, ability to form colonies in semi-solid media, and tumor formation in mice, suggesting that GMA has potential carcinogenic effects.
Objective: In order to assessment the Huperzine A (HupA) on CNS of mice exposed by phoxim and isocarbophos.
Methods: One group was given tween-80 or peanut oil as control. One group was given phoxim or isocarbophos alone as phoxim or isocarbophos group.
[Experimental study on protective effects of HupA in the treatment of isocarbophos poisoning].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
June 2006
Objective: To investigate the therapeutic and prophylactic efficiency of HupA in mice with acute isocarbophos poisoning, and the protective effects of the HupA on AChE inhibited by isocarbophos.
Methods: Mice were randomizedly divided into the non-treatment group, the atropine control group, the HupA treatment group and the atropine and HupA combined treatment group. Toxic signs and survival rates were observed and compared among these groups.