Publications by authors named "Guang-yu Ma"
Solitary bone plasmacytoma: Long-term clinical outcomes in a single center.
Curr Probl Cancer
June 2024
Background: A solitary plasmacytoma is classified into a solitary plasmacytoma of the bone (SBP) and a solitary extramedullary (soft tissue mass) plasmacytoma, based on the site of the lesion. Despite the high local control rate with radiotherapy, approximately half of patients' conditions progress to multiple myeloma (MM) within 3-5 years after diagnosis, with SBP having a worse prognosis.
Patients And Methods: We retrospectively assessed the treatment and outcomes of patients with SBP in a hospital in China from 2008 to 2021.
[Effects of paroxetine on protein kinase PKA, PKC and CaMKII activity in different brain regions in a rat depression model].
Nan Fang Yi Ke Da Xue Xue Bao
July 2008
Objective: To evaluate the effects of paroxetine on protein kinase PKA, PKC and CaMKII activities in different brain regions in a rat model of depression.
Methods: Thirty-six adult male SD rats were randomized into 6 groups, including one control group (I) and 5 groups of depression model established by forcing the rats to swim for 4 weeks. The 5 depression groups received no treatment (II) or were treated with paroxetine at a single dose (III), for a week (IV), 2 weeks (V) or 4 weeks (VI).
Objective: To evaluate the efficacy of phenobarbital in treatment of patients with convulsive forms of epilepsy in rural areas and to develop a suitable relevant model for rural China.
Methods: A demonstration protocol was conducted in the rural areas of 8 counties from 6 provinces and municipality in China, Heilongjiang, Ningxia, Henan, Jiangsu, Shanxi, and Shanghai from December 2001 to June 2004. Epidemiological investigation of the prevalence and treatment gap of epilepsy was carried out.
Article Synopsis
- Previous research indicated that phenytoin might protect the hippocampus from chronic stress damage, but its ability to reverse stress-related issues was unclear.
- The study found that while chronic stress increased motor activity in rats, phenytoin did not change this; however, it successfully reversed long-term memory deficits related to stress as observed through water maze tests.
- Electrophysiological measurements showed that phenytoin helped maintain long-term potentiation (LTP) in the hippocampal CA1 region, suggesting it might be beneficial for treating memory issues linked to depression.
Background: Uptake of aluminum may disturb the learning and memory of humans or animals. Naloxone (NAL) has been shown to exert beneficial effects on memory deficits.
Aims: We investigated the effects of naloxone on aluminum-induced learning and memory impairment in rats.
Objective: To assess the safety and efficacy of gabapentin in treatment of refractory epilepsy.
Methods: Sixty-six patients with refractory epilepsy were treated with gabapentin 200 mg/d and 72 patients with placebo, totally 138 patients in five hospitals in different cities in China. Double-blind study was performed to observe the times of seizure, and Mini-Mental State Examination (MMSE) and Activities of Daily Life (ADL) assessment were conducted every 4 weeks.
Background & Objectives: The endogenous opioid system plays an important role in cognitive functions and may also contribute to the progression of some kind of dementia. Naloxone has been shown to exert beneficial effects on memory deficits in patients with senile dementia and reverse some of the effects induced by endogeneous opioids. We therefore investigated the effects of naloxone on cognitive function in rats with vascular dementia (VD).
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