Publications by authors named "Guang-peng Zhou"
Article Synopsis
- Liver transplantation rejection is a significant issue, and the role of myeloid-derived suppressor cells (MDSCs) in this process is not well understood.
- This study investigated MDSCs by analyzing liver tissues and blood samples from patients and mouse models during varying degrees of rejection, finding a correlation between high rejection levels and increased M-MDSC and PD-1+ T-cell presence.
- Results revealed that CD84 plays a critical role in regulating M-MDSC functions, promoting T-cell exhaustion and possibly contributing to liver transplant rejection dynamics.
Article Synopsis
- Liver transplantation (LT) has been explored as a treatment for children with methylmalonic acidemia (MMA), but its overall effectiveness and impact on quality of life (HRQoL) remain debated.
- A study evaluated 15 MMA patients who underwent LT, comparing their health metrics before and after surgery—including metabolic control, growth, and neurological outcomes—over a follow-up period of 1.3 to 8.2 years.
- Results showed that LT led to significant improvements in height, metabolic stability, and HRQoL scores for both patients and their families, although their scores were still lower than those of children with biliary atresia (BA).
Background: Liver allograft fibrosis (LAF) is prevalent among children with long-term survival after liver transplantation (LT). The authors aimed to identify clinical risk factors, with a focus on the impact of immunosuppression (IS) level in the early post-transplant period on LAF.
Methods: A retrospective study was conducted on pediatric LT recipients with at least 1-year of follow-up.
Background: Exosomes exert considerable influence in mediating regulatory T (Treg) cells differentiation, which attach great importance to attenuating acute cellular rejection after liver transplantation (LT). And, miRNAs are known to play essential roles in cell-cell communication delivered by exosomes. However, the function of exosomal miRNAs in regulating Treg cells after LT remains unknown.
View Article and Find Full Text PDFBackground And Aims: Patients with biliary atresia (BA) are prone to hepatic decompensation, which might eventually lead to death. This study aimed to identify the possible risk factors affecting in-hospital death in BA patients in China.
Methods: We collected data from the Hospital Quality Monitoring System, a national inpatient database.
Background: Explanted livers from patients with inherited metabolic liver diseases possess the potential to be a cell source of good-quality hepatocytes for hepatocyte transplantation (HT). This study evaluated the therapeutic effects of domino HT using hepatocytes isolated from explanted human livers for acute liver failure (ALF).
Methods: Isolated hepatocytes were evaluated for viability and function and then transplanted into D-galactosamine/lipopolysaccharide-induced ALF mice via splenic injection.
Objective: To systematically evaluate the impact of diabetes on the prognosis of bladder cancer patients after radical cystectomy (RC).
Methods: PubMed, Embase, and Cochrane Library databases were selected from inception to October 2021. The studies on the effects of diabetes on bladder cancer patients after RC were included for analysis.
Article Synopsis
- Liver transplantation (LT) is a successful treatment for end-stage liver disease, but immune rejection poses a major challenge to patient survival and prognosis.
- The study utilized a protein chip system and proteomics to analyze serum proinflammatory cytokines and liver tissue proteins in a mouse model, revealing significant changes in cytokine levels post-transplant.
- Key findings included increased levels of GC-CSF, CXCL-1, MCP-5, and CXCL-2, along with the identification of enriched pathways related to immune responses and specific proteins associated with transplant rejection, suggesting new targets for treatment.
Article Synopsis
- New research highlights the important role of group 2 innate lymphoid cells (ILC2s) in regulating the immune response during liver transplantation (LT), especially in the context of acute rejection.
- The study found that while the number of circulating ILC2s was similar in transplant patients, those experiencing rejection had significantly higher levels of hepatic ILC2s compared to non-rejecting patients and controls.
- In a mouse model, ILC2 counts increased dramatically in the liver and bone marrow within the first two weeks post-transplant, indicating that these cells might work alongside regulatory T cells (Tregs) to help manage immune responses and potentially mitigate rejection.
Hepatic ischemia-reperfusion injury (IRI) is an adverse consequence of hepatectomy or liver transplantation. Recently, immune mechanisms involved in hepatic IRI have attracted increased attention of investigators working in this area. In specific, group 2 innate lymphoid cells (ILC2s), have been strongly implicated in mediating type 2 inflammation.
View Article and Find Full Text PDFObjective: Nonalcoholic steatohepatitis (NASH) is a dramatically growing indication for liver transplantation (LT) worldwide and the posttransplant outcomes of NASH patients are currently under intensive investigation. This quantitative meta-analysis aimed to update the clinical evidence on outcomes of transplanted patients with NASH.
Methods: We performed a systematic review and meta-analysis of studies (published up to September 15, 2021) that focused on LT outcomes for NASH versus non-NASH patients.
Characteristics of changes in double positive CD4CD8 T cells in liver transplantation.
Int Immunopharmacol
September 2022
Although double positive CD4CD8 T (DPT) cells has been reported to be involved in some diseases, their trajectory and function as associated with liver transplantation (LT) remain unclear. In the present study, we found that the number of DPT cells was increased in the blood and liver tissue of LT patients. Meanwhile, we compared the distribution of DPT cells in peripheral blood samples and in penetrating liver tissue between liver rejection versus non-rejection patients, as well as the proportion of DPT cells as a function of the extent of liver rejection.
View Article and Find Full Text PDFBackground: Graft-infiltrated dendritic cells (DCs) and CD8 T lymphocytes are closely related with immune regulation after liver transplantation (LT). An additional factor which appears to play an important role with regard to transplantation immunity are exosomes, which are membrane-derived small vesicles released by various cells. However, the regulation of CD80 DCs derived exosomes on CD8 T cells in response to LT remains unclear.
View Article and Find Full Text PDFBackground: Current world experience regarding living donor liver transplantation (LDLT) in the treatment of propionic acidemia (PA) is limited, especially in terms of using obligate heterozygous carriers as donors. This study aimed to evaluate the clinical outcomes of LDLT in children with PA.
Methods: From November 2017 to January 2020, 7 of the 192 children who underwent LDLT at our institution had been diagnosed with PA (median age, 2.
Adult-to-adult living donor liver transplantation with small partial liver grafts often requires intraoperative portal inflow modulation to prevent portal hyperperfusion and subsequent small-for-size syndrome (SFSS). However, there are concerns about the specific morbidity of these modulation techniques. This study aims to lower post-perfusion portal venous pressure and correct severe hypersplenism in a patient with end-stage liver cirrhosis by simultaneous subtotal splenectomy during auxiliary partial orthotopic liver transplantation (APOLT).
View Article and Find Full Text PDFIt remains unclear as to whether there are differences that exist in the types and functional status of immune cells within different areas of the liver lobules after rejection of liver transplantation. The composition of infiltrating T cells in liver allografts during liver transplantation rejection is indistinct and difficult to visualize within the same biopsy slide. In an attempt to rectify this problem, we applied multiplex immunofluorescent assays to assess the spatial distribution of various types of infiltrating T cells in different areas of the liver lobules after liver transplantation.
View Article and Find Full Text PDFBackground: Simultaneous splenectomy during liver transplantation is indicated for patients with cirrhosis complicated by severe hypersplenism, but disastrous procedure-related complications remain a special concern. Simultaneous partial splenectomy was adopted in pediatric liver transplant recipients with severe hypersplenism-related pancytopenia at our institution.
Methods: A prospective, single-center analysis of 21 pediatric patients diagnosed with cirrhosis and severe hypersplenism, who underwent liver transplantation between January 2015 to December 2019, was conducted.
Unlabelled: Background-objectives: Liver transplantation (LT) and combined liver and kidney transplantation (CLKT) have been proposed as enzyme replacement therapies for methylmalonic aciduria (MMA). We aimed to synthesize the available evidence on their safety and efficacy.
Methods: Medline, Embase and Cochrane library were searched to identify studies that reported post-LT/CLKT clinical outcomes of MMA from their inception to February 1, 2020.
Objectives: The alleged benefit of early placement of transjugular intrahepatic portosystemic shunt (TIPS) in patients with cirrhosis and acute variceal bleeding (AVB) remains controversial. This meta-analysis was conducted to evaluate the therapeutic effect of early TIPS on cirrhotic patients with AVB.
Methods: MEDLINE, Embase, and Cochrane Central Register of Controlled Trials databases were searched for relevant literatures.
Background: Ethylmalonic encephalopathy (EE) is a rare autosomal recessive metabolic disorder caused by impaired mitochondrial sulfur dioxygenase. Due to poor therapeutic effect of current conventional treatments, progressive psychomotor regression and neurological impairment usually contribute to early death in the first decade of life. Liver transplantation (LT) is emerging as a novel therapeutic option for EE; however, worldwide experience is still limited.
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