Plasma metabolomics profiles indicate sex differences of lipid metabolism in patients with Parkinson's disease.

The effect of sexual dimorphism on the metabolism of patients with Parkinson's disease has not been clarified. A group of patients with Parkinson's disease and healthy controls were recruited, and their clinical characteristics and plasma were collected. Untargeted liquid chromatography-mass spectrometry-based plasma metabolomics profiling was performed.

The current state and trends of immunotherapy research in lung cancer: a review and bibliometric analysis.

In recent years, the integration of immunotherapy in the treatment of lung cancer has marked a significant evolution in the field. This is evidenced by the surge in the volume of scientific publications, reflecting rapid advances over time. This paper presents a bibliometric analysis of lung cancer and immunotherapy research from January 2012 to December 2022, drawing on the Web of Science literature database and using the citexs data analysis platform to examine the shifts in topic hotspots over the decade.

Androgen signaling inhibits lipogenesis to alleviate lipid deposition in zebrafish.

Testosterone is closely associated with lipid metabolism and known to affect body fat composition and muscle mass in males. However, the mechanisms by which testosterone acts on lipid metabolism are not yet fully understood, especially in teleosts. In this study, -/- zebrafish ( ) exhibited excessive visceral adipose tissue (VAT), lipid content, and up-regulated expression and activity of hepatic lipogenesis (DNL) enzymes.

Combination of High-Throughput Screening and Assembly to Discover Efficient Metal-Organic Frameworks on Kr/Xe Adsorption Separation.

Recycling Kr and Xe from used nuclear fuel (UNF) is conducive to regenerating economy and protecting the environment, and it is urgent to screen or design high-performance cutting-edge metal-organic framework (MOF) materials for Kr/Xe adsorption separation. After grand canonical Monte Carlo (GCMC) simulations of Kr/Xe adsorption separation on 11,000 frameworks in CoRE MOFs (2019), the important structure-adsorption property relationship (SAPR) was induced; that is, the porosity (φ) at 0.30-0.

Ligand-dependent structural diversity and optimizable CO chemical fixation activities of Cu-doped polyoxo-titanium clusters.

Heterometallic oxo clusters have been attracting intensive interest due to their unique properties originating from the synergistic interactions between different components. Herein, we report the construction and catalytic applications of a family of copper-doped polyoxo-titanium clusters (Cu-PTCs) coordinated with different acetate derivative ligands. The solvothermal reactions of metal salts and trimethylacetic acid or 1,2-phenylenediacetic acid in ethanol produced TiCu(μ-O)(μ-O)(OEt)(L1) (L1 = trimethyl acetate, PTC-367) and HTiCuBr(μ-O)(μ-O)(OEt)(L2) (L2 = 1,2-phenylenediacetate, PTC-368), respectively.

Enhancing Third-Order Nonlinear Optical Property by Regulating Interaction between Zr(embonate) Cage and N, N-Chelated Transition-Metal Cation.

Herein, the combination of anionic ZrL (L = embonate) cages and N, N-chelated transition-metal cations leads to a series of new cage-based architectures, including ion pair structures ( and ), dimer (), and 3D frameworks ( and ). Structural analyses show that exhibits a 2-fold interpenetrating framework with a 3,4-connected topology, and shows a 2-fold interpenetrating framework with a 4-connected network. Both and can be stable in air and other common solvents at room temperature.

Post-Assembly Modification of Homochiral Titanium-Organic Cages for Recognition and Separation of Molecular Isomers.

A chiral metal-organic cage (MOC) was extended and fixed into a porous framework using a post-assembly modification strategy, which made it easier to study the host-guest chemistry of the solid-state MOC using a single-crystal diffraction technique. Anionic Ti L (L=embonate) cage can be used as a 4-connecting crystal engineering tecton, and its optical resolution was achieved, thus homochiral ΔΔΔΔ- and ΛΛΛΛ-[Ti L ] cages were obtained. Accordingly, a pair of homochiral cage-based microporous frameworks (PTC-236(Δ) and PTC-236(Λ)) were easily prepared by a post-assembly reaction.

CuTi-oxo clusters functionalized by - generated 2,2'-biphenolate ligands from the oxidative coupling of phenols.

Herein, we report a twisted cubic Cu(I)Ti(IV)-oxo cluster stabilized by - formed 2,2'-biphenolate ligands from the oxidative coupling of phenols. The 2,2'-biphenolate-functionalized Cu(I)Ti(IV)O cluster shows short Cu⋯C contacts and exhibits smaller HOMO-LUMO gaps than those of reported Ti(IV)O.

Discovery of octahydropyrrolo [3,2-b] pyridin derivative as a highly selective Type I inhibitor of FGFR3 over VEGFR2 by high-throughput virtual screening.

Although the aberrant activity of fibroblast growth factor receptor 3 (FGFR3) is implicated in various cancers, the reported kinase inhibitors of FGFR3 tend to cause side effects resulting from the inhibitory activity on vascular endothelial growth factor receptor 2 (VEGFR2). Therefore, it is necessary to find a novel high-selective inhibitor of FGFR3 over VEGFR2 from the small-molecule compound database. In this study, integrated virtual screening protocols were established to screen for selective inhibitors of FGFR3 over VEGFR2 in Drugbank and Asinex databases by combining three-dimensional pharmacophore model, molecular docking, molecular dynamics (MD) simulation, and molecular mechanics Poisson-Boltzmann surface area (MMPBSA) calculations.

Iron-N-heterocyclic carbene complexes as efficient electrocatalysts for water oxidation under acidic conditions.

The development of stable, Earth-abundant, and high-activity molecular water oxidation catalysts under acidic and neutral conditions remains a great challenge. Here, the use of N-heterocyclic carbene (NHC)-based iron(III) complex 1 {[phenyl(tris(3-methylimidazol-1-ylidene))borate]Fe(III)} as a catalyst for water oxidation under acidic and neutral conditions was investigated. Two iron(II) carbene complexes, 2 {[2,6-bis(3-methylimidazolium-1-yl)pyridine]Fe} and 3 {[2,6-bis(3-methylimidazolium-1-yl)pyridine-4-carboxylic acid]Fe}, were also used for comparison.

Iron increases lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the HIF1α-PPARγ pathway.

Iron is an essential micro-element, involved in multiple biological activities in vertebrates. Excess iron accumulation has been identified as an important mediator of lipid deposition. However, the underlying mechanisms remain unknown.

["Water-pathogen" theory-based Juanyin Tongluo Recipe for varicocele complicated with oligozoospermia: A clinical observation].

Objective: To observe the clinical efficacy of the "water-pathogen" theory-based Juanyin Tongluo Recipe (JTR) in the treatment of varicocele (VC) complicated with oligozoospermia and its effects on the semen parameters, sperm morphology, sperm DNA fragmentation index (DFI) and testis volume of the patient.

Methods: Ninety-two VC patients complicated with oligozoospermia were randomly assigned to receive JTR (n = 47) and Maizhiling Tablets (the control group, n = 45), respectively, both for three months, followed by comparisons of the clinical effects, total sperm count, sperm motility, percentages of progressively motile sperm (PMS) and morphologically normal sperm (MNS), sperm DNA fragmentation index (DFI) and testis volume of the patients before and after medication, and the pregnancy rate after treatment between the two groups.

Results: The total rate of effectiveness was significantly higher in the JTR than in the control group (87.

[Baihe Yuzi Prescription improves asthenospermia by up-regulating the expression of CFTR in the sperm].

Objective: To observe the therapeutic efficacy of Baihe Yuzi Prescription (BYP) in the treatment of clinical syndrome-free asthenospermia and its effects on semen parameters, sperm DNA fragmentation index (DFI) and the expression of the cystic fibrosis transmembrane conductance regulator (CFTR) in the sperm.

Methods: We randomly divided 112 patients with clinical syndrome-free asthenospermia into a control group (n = 55) and an experimental group (n = 57), the former treated orally with L-carnitine liquid combined with vitamin E capsules and the latter with BYP in addition, both for 3 months. After treatment, we obtained the total sperm count, sperm motility, percentages of progressively motile sperm (PMS) and morphologically normal sperm (MNS), sperm DFI and expression of CFTR in the sperm, and compared the above parameters between the two groups of patients before and after medication.

Inorganic acid influenced formation of Ti and Ti oxysulfate clusters with toroidal and capsule structures.

We herein report the discovery of inorganic toroidal and capsule titanium oxysulfate clusters by ionothermal synthesis. The ratio between geometrically different anions (tetrahedral SO pseudo-tetrahedral PO) shows an interesting influence on cluster structure formation.

Triethanolamine stabilized non-alkyl SnCd and alkyl SnCd oxo clusters with distinct electrocatalytic activities.

Two unprecedented Sn/Cd-oxo clusters, including non-alkyltin SnSnCd and alkyltin SnCd, have been constructed using triethanolamine and inorganic or organic tin precursors, respectively. Comparative electrocatalytic CO reduction experiments show that the presence of non-alkyl and variable-valent tin centres could greatly improve the catalytic activities.

Isolation, Characterization, and Tea Growth-Promoting Analysis of JW-CZ2, a Bacterium With 1-Aminocyclopropane-1-Carboxylic Acid Deaminase Activity Isolated From the Rhizosphere Soils of Tea Plants.

One of the major mechanisms underlying plant growth-promoting rhizobacteria (PGPR) is the lowering of ethylene level in plants by deamination of 1-aminocyclopropane-1-carboxylic acid (ACC) in the environment. In the present study, using ACC as the sole nitrogen source, we screened seven ACC deaminase-producing bacterial strains from rhizosphere soils of tea plants. The strain with the highest ACC deaminase activity was identified as strain JW-CZ2.

Preparation and Visible-Light Response of Salicylate-Stabilized Heterobimetallic Pb-Ti-Oxo Clusters Initiated via Auxiliary Quaternary Ammonium Salts and a Solvent Effect.

In this study, with the assistance of quaternary ammonium salts we have successfully prepared a new family of salicylate-stabilized heterobimetallic Pb-Ti-oxo clusters, including H(TEA)[PbTi(μ-O)(μ-O)(OPr)(PA)(Sal)(NO)] (; TEA = tetraethylammonium; HOPr = isopropanol; HPA = phenylphosphonic acid; HSal = salicylic acid), {PbTi(μ-O)(μ-O)(OPr)(PA)(Sal)(DMF)·CHCN} (; DMF = dimethylformamide), {PbTi(μ-O)(Sal)(CHCOO)(DMF)(OPr)} (), [PbTi(Sal)(EtO)(OPr)(HOPr)]·CHNH (; EtOH = CHCHOH), H[PbTi(μ-O)(μ-O)(μ-O)(Sal)(OPr)] (), and PbTi(μ-O)(μ-O)(μ-O)(Sal)(OEt) (). Single-crystal X-ray diffraction studies demonstrate that the {TiPb(Sal)} unit acts as the building block to constitute the diverse assembly of . Thereinto, the clusters in and are connected into infinite one-dimensional chains.

A Water-Soluble Highly Oxidizing Cobalt Molecular Catalyst Designed for Bioinspired Water Oxidation.

Herein, we present a stable water-soluble cobalt complex supported by a dianionic 2,2'-([2,2'-bipyridine]-6,6'-diyl)bis(propan-2-ol) ligand scaffold, which is a rare example of a high-oxidation species, as demonstrated by structural, spectroscopic and theoretical data. Electron paramagnetic resonance (EPR) spectroscopy and magnetic susceptibility measurements revealed that the Co center of the mononuclear complex in the solid state resides in the high spin state (sextet, S=5/2). The complex can effectively catalyze water oxidation via a single-site water nucleophilic attack pathway with an overpotential of only 360 mV in a phosphate buffer with a pH of 6.

Mitochondria-Dependent Oxidative Stress Mediates ZnO Nanoparticle (ZnO NP)-Induced Mitophagy and Lipotoxicity in Freshwater Teleost Fish.

Due to many special characteristics, zinc oxide nanoparticles (ZnO NPs) are widely used all over the world, leading to their wide distribution in the environment. However, the toxicities and mechanisms of environmental ZnO NP-induced changes of physiological processes and metabolism remain largely unknown. Here, we found that addition of dietary ZnO NPs disturbed hepatic Zn metabolism, increased hepatic Zn and lipid accumulation, downregulated lipolysis, induced oxidative stress, and activated mitophagy; ,,','-tetrakis (2-pyridylmethyl) ethylenediamine (TPEN, Zn ions chelator) alleviated high ZnO NP-induced Zn and lipid accumulation, oxidative stress, and mitophagy.

Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway.

Ferroptosis is a regulated form of cell death induced by iron (Fe)-dependent lipid peroxidation. At present, the underlying molecular mechanisms remain elusive. Herein, we hypothesized that mitochondria and the NRF2 (transcription factor nuclear factor E2-related factor 2) are potential mediators of ferroptosis, considering their well-established involvement in the oxidative stress pathway.

Synthesis, Structure, and Light Absorption Behaviors of Prismatic Titanium-Oxo Clusters Containing Lacunary Lindqvist-like Species.

Exploring new structural types of polyoxotitanium clusters (PTCs), especially those containing classical polyoxometalates structures, has always been the focus of research in the field of metal-oxo clusters. In this work, we present the synthesis and characterization of three prismatic PTCs: namely, Ti(μ-O)(μ-O)(OPr)(HOPr)(L1) (; HL1 = 3,5-di--butylcatechol), Ti(μ-O)(μ-O)(OPr)(L2)(L3) (; HL2 = 1-adamantanecarboxylic acid, HL3 = 2-picolinic acid), and [Ti(μ-O)(μ-O)(μ-O)(OPr)(L3)](L3) (). Single-crystal X-ray diffraction analyses indicate that the construction of these prismatic PTCs is based on a stepwise interlayer assembly of {Ti} and {Ti} substructures.

Coordination Assembly of Tetrahedral Zr(embonate) Cages with Eu Ions.

Herein we systematically investigated the coordination assembly behavior of ZrL cages with Eu ions at room temperature. Through adjustment of the concentration of Eu salt and changes of the type and molar ratio of the solvent, a series of ZrL-Eu structures with different structure dimensionalities have been synthesized and structurally characterized. In addition, we also studied the optical properties of these materials in detail, including the fluorescent and third-order nonlinear-optical properties.

Dietary Nano-ZnO Is Absorbed via Endocytosis and ZIP Pathways, Upregulates Lipogenesis, and Induces Lipotoxicity in the Intestine of Yellow Catfish.

Nano-sized zinc oxide (nano-ZnO) affects lipid deposition, but its absorption patterns and mechanisms affecting lipid metabolism are still unclear. This study was undertaken to investigate the molecular mechanism of nano-ZnO absorption and its effects on lipid metabolism in the intestinal tissues of a widely distributed freshwater teleost yellow catfish . We found that 100 mg/kg dietary nano-ZnO (H-Zn group) significantly increased intestinal Zn contents.