[Association analysis of the parkin gene in patients with sporadic Parkinson's disease from a Han population of Sichuan province].

Objective: To determine whether there are any associations between the -258T/G polymorphism of the promoter and the IVS3 -20T/C polymorphism in parkin gene and Parkinson's disease (PD) from a Han population in Sichuan province.

Methods: Polymerase chain reaction (PCR), restriction fragment length polymorphism, denaturing high performance liquid chromatography(dHPLC) and sequence analysis were used to determine the genotype of each subject. The -258T/G polymorphism and IVS3 -20T/C polymorphism were analysed in 198 patients with sporadic PD and 187 healthy controls, matched for age and gender.

[Effect of batroxobin on K+ channel activated by Ca2+ in primary culture rat cortex neurons of rat].

Objective: To investigate the effect of batroxobin on K+ channel activated by Ca2+ in primary cultured cortex neurons of fetal SD rat.

Methods: The patch clamp technique of single channel recordings including cell-attach and inside-out mode was used.

Results: Extracellular batroxobin activated the Kca.

[Effect of the Ca2+ -activated K+ channel in veratridine-induced cortex neurons damage].

Aim: To observe the effects of Ca2+ -activated K+ channel of primary cultured fetal SD rat cortex neurons in the veratridine triggered neuronal damage.

Methods: The patch clamp technique of cell-attach and inside-out mode for these two kinds of single channel recordings were used.

Results: Extracellular veratridine activated the Kca.

Proportion of different subtypes of stroke in China.

Background And Purpose: The goal of this article is to clarify the proportion of stroke subtypes in China, where stoke is the most common cause of death.

Methods: A total of 16,031 first-ever strokes in subjects >or=25 years of age were identified in 1991 to 2000 from 17 Chinese populations through a community-based cardiovascular disease surveillance program in the China Multicenter Collaborative Study of Cardiovascular Epidemiology. World Health Organization diagnosis criteria were used for classification of stroke subtypes.

[The incidence of ischemic and hemorrhagic stroke in Chinese populations].

Objective: To study the ratio of ischemic to hemorrhagic stroke incidence in Chinese populations.

Methods: Fifteen populations in China, each including about 100,000 residents, were monitored from 1991 to 2000 for the occurrence of stroke. Stroke was classified as hemorrhagic, ischemic and unclassified based on the clinical data and CT scan results respectively.