Publications by authors named "Guang-di Zhou"
Article Synopsis
- Ovarian cancer is a serious condition with low survival rates, especially after relapse, and is the most common malignant tumor affecting the female reproductive system.
- A 56-year-old patient with high-grade serous papillary adenocarcinoma underwent radical surgery and chemotherapy, but despite initial success, her cancer relapsed and resisted various treatments.
- Anti-PD-1 immunotherapy (tislelizumab) ultimately led to complete tumor remission for 32 months, indicating potential long-term benefits for some patients with refractory tumors, though further research is necessary to determine who may benefit most from this therapy.
Article Synopsis
- - The study investigates how fetal overgrowth correlates with an increased risk of type 2 diabetes in adulthood, focusing on epigenetic changes, specifically DNA methylation in the placenta.
- - Researchers discovered 543 positions of differential methylation in placental genes between large-for-gestational-age (LGA) and optimal-for-gestational-age (OGA) infants, with certain genes accounting for significant variations in birth weight.
- - Validated findings highlight hypermethylation of genes VSX1 and CDH13 in LGA cases and show that while the adiponectin gene's methylation in placenta is linked to its levels in cord blood, leptin and fetal growth factors do not show such relationships.
[Genetic association of apoE and apoCI gene polymorphisms with coronary heart disease].
Zhonghua Liu Xing Bing Xue Za Zhi
November 2004
Objective: To study the genetic association of apolipoprotein (apo) E and apoCI gene polymorphisms with coronary heart disease (CHD) in China.
Methods: apoE genotypes were identified by multiplex amplification refractory mutation system (multi-ARMS) and the apoCI promoter polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 186 cases with CHD (age: 65.0 +/- 10.
Objective: To investigate the association between the ApoE and LDLR-R gene loci on coronary heart disease (CHD) and their interaction with alcohol drinking and smoking in Hans of Chinese.
Methods: A questionnaire survey of the behaviors of smoking and drinking, dietary custom, and anamnesis, was conducted among 146 cases of CHD, aged 64 +/- 11, and 340 controls, aged 63 +/- 12. Peripheral blood samples were collected and the total DNAs were extracted.