[Effect of carbon disulfide on oxidation-antioxidation function of rat nerve tissues.].

Objective: To investigate the effect of carbon disulfide (CS(2)) on oxidation-antioxidation function of rat nerve tissues.

Methods: Thirty male Wistar rats were randomly divided into the control group, the low-dosage exposure group and the high-dosage group, 10 rats each. The rats of the two exposure groups were administered with CS(2) by gavage at a dosage of 300 or 500 mgxkg(-1)xd(-1), 5 times every week for continuous 12 weeks.

[Alterations of microtubule and microfilament expression in spinal cord of carbon disulfide intoxicated rats].

Objective: To investigate whether the alterations of microtubule and microfilament expression are responsible for the neurotoxicity of carbon disulfide.

Methods: Wistar rats were administered with carbon disulfide by gavage at a dosage of 300 or 500 mg/kg for continuous 12 weeks (five times per week). Spinal cords of carbon disulfide-intoxicated rats and their age-matched controls were Triton-extracted and ultracentrifuged to yield a pellet and a corresponding supernatant fraction.