Tumor RNA-loaded nanoliposomes increases the anti-tumor immune response in colorectal cancer.

Purpose: Tumor RNA vaccines can activate dendritic cells to generate systemic anti-tumor immune response. However, due to easily degraded of RNA, direct RNA vaccine is less effective. In this study, we optimized the method for preparing PEGylated liposom-polycationic DNA complex (LPD) nanoliposomes, increased encapsulate amount of total RNA derived from CT-26 colorectal cancer cells.

Correction: Rapid room temperature synthesis of red iridium(iii) complexes containing a four-membered Ir-S-C-S chelating ring for highly efficient OLEDs with EQE over 30.

[This corrects the article DOI: 10.1039/C8SC05605F.].

Pure Red Iridium(III) Complexes Possessing Good Electron Mobility with 1,5-Naphthyridin-4-ol Derivatives for High-Performance OLEDs with an EQE over 31.

Three iridium(III) complexes (Ir(4tfmpq)mND, Ir(4tfmpq)mmND, and Ir(4tfmpq)mpND) with the 4-(4-(trifluoromethyl)phenyl)quinazoline (4tfmpq) main ligand and 1,5-naphthyridin-4-ol derivatives (mND: 8-methyl-1,5-naphthyridin-4-ol, mmND: 2,8-dimethyl-1,5-naphthyridin-4-ol, mpND: 8-methyl-2-phenyl-1,5-naphthyridin-4-ol) as ancillary ligands were studied. The complexes (Ir(4tfmpq)mND, Ir(4tfmpq)mmND, and Ir(4tfmpq)mpND) emit pure red emissions of 626-630 nm with high photoluminescence quantum yields of 85.2-93.

Rapid room temperature synthesis of red iridium(iii) complexes containing a four-membered Ir-S-C-S chelating ring for highly efficient OLEDs with EQE over 30.

Three red cyclometalated iridium(iii) complexes (4tfmpq)Ir(dipdtc), (4tfmpq)Ir(dpdtc) and (4tfmpq)Ir(Czdtc) (4tfmpq = 4-(4-(trifluoromethyl)phenyl)quinazoline, dipdtc = ,-diisopropyl dithiocarbamate, dpdtc = ,-diphenyl dithiocarbamate, and Czdtc = -carbazolyl dithiocarbamate) containing the unique four-membered Ir-S-C-S backbone ring were synthesized in five minutes at room temperature with good yields, and the Gibbs free energy calculation results indicate that all reactions are exothermic and thermodynamically favorable processes. The emission colors ( = 641-611 nm), photoluminescence quantum efficiencies ( = 58.3-93.

Two platinum(ii) complexes with a 4-phenyl-4H-1,2,4-triazole derivative as an ancillary ligand for efficient green OLEDs.

Two new cyclometalated platinum(ii) complexes ((TNT)Pt(dptp), (4tfmppy)Pt(dptp)) with 2',6'-bis(trifluoromethyl)-2,3'-bipyridine (TNT) and 4-trifluoromethylphenylpyridine (4tfmppy) as the cyclometalated ligands and the nitrogen heterocycle 2-(4,5-diphenyl-4H-1,2,4-triazol-3-yl)phenol (dptp) as the ancillary ligand were developed. Both complexes are green phosphors with high photoluminescence quantum efficiency yields (λ = 532 nm, Φ = 65% for (TNT)Pt(dptp) and λ = 502 nm, Φ = 71% for (4tfmppy)Pt(dptp)) in CHCl solutions at room temperature, respectively. Organic light-emitting diodes (OLEDs) with single-emitting layer and double-emitting layer structures were fabricated with good performances.

Efficient orange-red electroluminescence of iridium complexes with 1-(2,6-bis(trifluoromethyl)pyridin-4-yl)isoquinoline and 4-(2,6-bis(trifluoromethyl)pyridin-4-yl)quinazoline ligands.

Two novel iridium(iii) complexes, Ir(tfmpiq)(acac) (tfmpiq = 1-(2,6-bis(trifluoromethyl)pyridin-4-yl)isoquinoline, acac = acetylacetone) and Ir(tfmpqz)(acac) (tfmpqz = 4-(2,6-bis(trifluoromethyl)pyridin-4-yl)quinazoline), were synthesized and thoroughly investigated. Both complexes emit orange-red photoluminescence with high quantum yields (Ir(tfmpiq)(acac): λ: 587 nm, η: 42%; Ir(tfmpqz)(acac): λ: 588 nm, η: 91%). Furthermore, the complex containing quinazoline shows higher electron mobility than that with isoquinoline.

Novel Design of Iridium Phosphors with Pyridinylphosphinate Ligands for High-Efficiency Blue Organic Light-emitting Diodes.

Due to the high quantum efficiency and wide scope of emission colors, iridium (Ir) (III) complexes have been widely applied as guest materials for OLEDs (organic light-emitting diodes). Contrary to well-developed Ir(III)-based red and green phosphorescent complexes, the efficient blue emitters are rare reported. Like the development of the LED, the absence of efficient and stable blue materials hinders the widely practical application of the OLEDs.

Syntheses, photoluminescence and electroluminescence of two novel platinum(ii) complexes.

Two new platinum(ii) cyclometalated complexes with 2-(4-trifluoromethyl)phenylpyridine (4-tfmppy) as the main ligand and tetraphenylimidodiphosphinate (tpip) (Pt-tpip) and tetra(4-fluorophenyl)imidodiphosphinate (ftpip) (Pt-ftpip) as ancillary ligands were developed. Both complexes were green phosphors with photoluminescence quantum efficiency yields of 71.5% and 79.

N-Heterocyclic carbenes: versatile second cyclometalated ligands for neutral iridium(III) heteroleptic complexes.

With 2-(2,4-difluorophenyl)pyridine (dfppy) as the first cyclometalated ligand and different monoanionic N-heterocyclic carbenes (NHCs) as the second cyclometalated ligands, 16 blue or greenish-blue neutral iridium(III) phosphorescent complexes, (dfppy)2Ir(NHC), were synthesized efficiently. The obtained Ir(III) complexes display typical phosphorescence of 455-485 nm with quantum yields up to 0.73.