Publications by authors named "Guang-Ze Wang"

Article Synopsis
  • Hainan Province, China has seen a history of endemic malaria, particularly from Plasmodium vivax, which was eliminated locally in 2011 but still experiences imported cases.
  • A study analyzed a total of 983 mitochondrial genome sequences, identifying 33 SNPs and 18 different haplotypes, revealing higher genetic diversity in Hainan compared to other Chinese provinces.
  • Most of Hainan's P. vivax haplotypes were closely related to those found in South/East Asia, with about half of the imported cases' origins traceable through phylogenetic analysis, while others remained unclear.
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A cerium-modified water hyacinth biochar adsorbent(Ce-BC) was developed through co-precipitation-pyrolysis to remove phosphate from wastewater. The study investigated the effects of Ce-BC dosing, wastewater pH, reaction time, and coexisting competing ions on the adsorption process. The results showed that the best adsorption performance was achieved with a maximum adsorption capacity of 35.

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is one of the major malaria vectors and among the dominant species in Hainan Province, China. The resistance of to insecticides is an important threat to malaria control. However, few reports on insecticide resistance of were reported in this area.

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In Hainan Province, China, great achievements in elimination of falciparum malaria have been made since 2010. There have been no locally acquired falciparum malaria cases since that time. The cost-effectiveness of elimination of falciparum malaria has been analyzed in Hainan Province.

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Background: Hainan Province is one of the most severe endemic regions with high transmission of Plasmodium falciparum and Plasmodium vivax in China. However, the incidence of P. falciparum and P.

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Pyronaridine and artesunate have been shown to be effective in falciparum malaria treatment. However, pyronaridine is rarely used in Hainan Island clinically, and artesunate is not widely used as a therapeutic agent. Instead, conventional antimalarial drugs, chloroquine and piperaquine, are used, explaining the emergence of chloroquine-resistant Plasmodium falciparum.

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Background: Historically, the incidence of malaria in the Hainan Province, China has been high. However, since 2001 the malaria incidence in Hainan has decreased due to large-scale, public educational, promotional campaigns and the adoption of preventative measures against malaria following the fast growth of socio-economic development. The present study analysed the correlation between prevention measures and social economic development on the incidence of malaria in Hainan from 2001 to 2013.

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Background: In the island of Hainan, the great majority of malaria cases occur in mountain worker populations. Using the behavioral change communication (BCC) strategy, an interventional study was conducted to promote mountain worker malaria prevention at a test site. This study found the methods and measures that are suitable for malaria prevention among mountain worker populations.

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A total of 78 malaria cases were reported in 2010 and the incidence of malaria in this year was 9 per million in Hainan Province. The positive rate of blood tests in floating population was higher than that in local residents, and the antibody-positive rate of residents was higher than that of students, and all the reported malaria patients received the correct treatment. The rate of the therapy for vivax malaria relapse was 96.

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Objective: To analyze the relationship between falciparum malaria incidence and the number of Anopheles dirus in Hainan Province from 2001 to 2008, so as to provide the evidence for malaria control and prevention in Hainan Province.

Methods: The falciparum malaria incidence and the numbers of Anopheles dirus in 2001 - 2008 were calculated according to the data from Wuzhishan City and Qiongzhong County in Hainan Province. The Cochran-Armitage trend test was employed to explore the trend of falciparum malaria incidence.

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Objective: To compare the usefulness of Tag-primer nested/multiplex PCR (UT-PCR) method with microscopy in malaria diagnosis and surveillance.

Methods: 400 blood smears and blood samples on filter paper were taken from febrile patients which were initially diagnosed as malaria or suspected malaria during surveillance in mixed endemic areas of Plasmodium falciparum (Pf) and P. vivax (Pv) in Hainan and Yunnan provinces and a malaria-controlled area in Guangxi Zhuang Autonomous Region.

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Objective: To assess the therapeutic efficacy of the combinations dihydroartemisinin-piperaquine and artemether-lumefantrine in treating uncomplicated falciparum malaria cases in an area with high level resistance of Plasmodium falciparum to chloroquine in Hainan Province.

Methods: Patients aged 1 to 60 with uncomplicated P. falciparum infection and parasite density 1,000 to 200,000 parasites/microl were enrolled following an informed consent.

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Objective: To develop a method for comparing the haplotypes of pfcrt polymorphism of Hainan Province with those from other areas of the world.

Methods: Nested PCR was used to amplify the polymorphic region including codon 72 to 76 and 97 of pfcrt gene. The PCR products were digested by ApoI restriction endonuclease to determine the allelic types.

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